Abstract The low-dose ozone concept with its moderate oxidative stress represents an ideal hormesis strategy. Dose-response and concentration-effect relationships in the context specific applications allow one to fix concentration ranges therapeutical benefit. Based on well-known reaction mechanisms of ozone, biochemical pharmacological effects, international guidelines have be defined concerning physiological resistant materials, indications, effective dosage range dependence indications....

Low-dose ozone acts as a bioregulator in chronic inflammatory diseases, biochemically characterized by high oxidative stress and blocked regulation. During systemic applications, “Ozone peroxides” are able to replace H2O2 its specific function of regulation, restore redox signaling, improve the antioxidant capacity. Two different mechanisms have be understood. Firstly, there is direct mechanism, used topical treatments, mostly via radical reactions. In indirect, ionic mechanism discussed:...

Now that indications are clearly defined, applications have mostly become standardized and the active mechanisms been well confirmed, medical ozone application in form of low-dose concept, is established proven as a complementary method treatment chronic inflammations or diseases associated with inflammatory conditions. More than 11,000 systemic treatments Major Ozone Autohemotherapy (MAH) 577 patients ≥ 47,000 Rectal Insufflations (RI) 716 various clinical studies subjected to critical...

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common arthritic diseases. Medical ozone has demonstrated its effectiveness in combination therapy with methotrexate or non-steroidal anti-inflammatory drugs for RA OA, respectively. Although OA have been compared from different points of view, few studies considered their redox status spite oxidative processes that involved both The aim this study was to compare evaluating effects on clinical response combined ozone. 80 patients...

Objectives:Epilepsy is a common seizure disorder affecting approximately 70 million people worldwide. Mitochondrial dysfunction and antioxidant/prooxidant imbalance are emerging as factors that contribute to epileptogenesis. As medical ozone was able reestablish cellular redox balance maintain the protective effects mediated by A1 receptors (A1Rs), aim of this work study ozone's on clarify if A1Rs play role in actions against pentylenetetrazole (PTZ)-induced convulsions...

The objective of this study was to evaluate the role ozone therapy (as a part comprehensive approach) with its different techniques in management diabetic foot problems and chronic nonhealing wounds. design included case series study, review literature. Researchers used an unit, Navy Diving Hyperbaric Medicine Institute, Ozone Therapy Unit, at Armed Forces Hospital, Alexandria, Egypt. All patients wounds were treated from August 2006 2009. Full history clinical examination identify...

Our hypothesis that controlled ozone applications interfere into the redox balance of biological organism (first published in 1998 with a preclinical trial on protecting liver from CCl4 intoxication), has been verified over last 2 decades reactive oxygen species (ROS)-induced mitochondrial pathologies, such as rheumatoid arthritis, osteoarthritis, aging processes, diabetes-2 and prevention intoxications. Low-dose acts bioregulator: The restoration disturbed is comprehensible number clinical...

Abstract In comparison with healthy tissue, freshly operated carcinomatous ovarial tissue was treated in vitro ozone a suitable medium using air as the reference. an analogous test arrangement and for reference purposes, cytostatics Adriblastin (= Doxorubicin, adriamycin) Holoxan Ifosfamide, cyclophosphamide) were included tumor tissue. After preparation of samples, following substances examined: 2,3-DPG, NAD (Nadide, DPN), Lecithin, Lysolecithin plus different enzymes metabolites both...

Hepatitis C is a medical problem in Egypt. The usual line of treatment very expensive, with major side effects and low efficacy especially genotype 4, which common Several studies were performed between 1999 2008 to evaluate the role ozone therapy HCV (Hepatitis C). first study included 60 4 patients, who received combined autohemotherapy three times per week for 8 weeks, followed by twice 16 weeks. It was found that, following weeks therapy, viral load decreased 91.67% cases attaining...

Ethanol withdrawal (EW) increases acetaldehyde accumulation and reactive oxygen species formation that promote damage to the brain. It is necessary emphasize while EtOH abuse dependence are widespread, treatment options extremely limited. This study aimed at investigating protective effects of Ozone Oxidative Postconditioning (OzoneOxPost) on brain injury induced by oxidative stress behavioral changes after 2 weeks EW in rats. Four groups rats (n = 10 each one) were settled: (I) Control,...

Abstract Chronic oxidative stress and acetaldehyde accumulation are associated with brain damage during Ethanol Withdrawal (EW). Ozone therapy is a regulator of cellular redox balance it controls important functions nervous system EW at experimental level. The aim this work was to develop pilot study in order evaluate the ozone´s effects on signs 10 patients "Before" "After" ozone treatments. improved 70% from Clinical Institute Scale (CIWA-Ar), mainly those Central Nervous System (CNS)....

In chronic inflammatory conditions and diseases accompanied by inflammation, the main indication range of systemically administered ozone, one basic mechanism action has emerged following low-dose ozone concept: Interference in diverse biological redox equilibria, its regulation at low concentrations. very special role glutathione balance recovery. It starts with oxidation GSH (active form glutathione) "ozone peroxides", after a considerable number regulatory processes mechanisms, finally...

Abstract In four groups of patients with chronic conditions receiving an ozone application (intravascular administration ozone/oxygen mixtures or without autohemotherapy), the immunoglobulins IgA, IgG and IgM were determined in serum; 1 2, lysozyme vitamin A values also measured. The broken down as follows: Group 1: 19 carcinoma cervix. 2: 20 ovaries. 3: (80% rheumatoid arthritis), shortterm study (34 patients). 4: long–term (47 further breakdown into statistical categories 2 showed no...

Abstract The type of application, the application range, and dosage a medical ozone/oxygen mixture (prepared from purest oxygen used in concentration between 1 100 g/mL) have been derived principally its employment preparation drinking water regeneration liquid waste. This is light bactericidal fungicidal properties – which clinical field also comes under heading disinfection addition to virucidal thus overall sterilizing property ozone. Furthermore, within biological system, different...

Medical ozone is a redox regulator with beneficial effects in oxidative etiology diseases such as rheumatoid arthritis (RA). The aim of this study was to conduct holistic review from different pharmacological trials involving model well the clinical response RA patients. ROS involved and its relationship main pathological pathways autoimmune disease were here considered. integrator analysis experimental results animals findings have revealed that both methotrexate (MTX) medical share common...

Abstract Ozone has strong antimicrobial activity and reactive oxygen intermediates play an important role in the immune defense against microbial infections. We investigated effect of ozone on malaria parasite Plasmodium falciparum vitro. A laboratory adapted P. strain was ozonated with 80 μg/ml growth determined for 4 days. inhibitory up to a factor 2.6 6.7 Day seen, depending basal parasitemia. also observed when parasites were added after ozonation culture medium. Ozonated leucocytes...

The best form of prevention against human infection through bacteria, viruses and other parasites is ozone disinfection wastewater drinking water as a highly effective, well-known method. As therapeutic measure, various preclinical studies showed promising results, which are being revisited reconsidered in times pandemics led to interesting results recent clinical trials reports, presented by the example protective measures covid-19 particularly vulnerable personnel. In patients with...

Medical ozone reestablishes cellular redox balance so that it may be a valid therapeutic approach in the prevention and management of age-related diseases with oxidative etiology older people. The aim this study is to evaluate stress some vasoactive substances elderly (60-70 years) rheumatoid arthritis patients diabetes hypertension, as well another group bronchial asthma order demonstrate beneficial effects medical therapy these age groups. A randomized clinical 45 was performed. Group I (n...