A5086923865- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Pharmacology and Obesity Treatment
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Regional Economic and Spatial Analysis
- Influenza Virus Research Studies
- Cardiac Imaging and Diagnostics
- Palliative and Oncologic Care
- Atrial Fibrillation Management and Outcomes
- Metabolism and Genetic Disorders
- Urticaria and Related Conditions
- Pharmacogenetics and Drug Metabolism
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Global trade and economics
- Nutritional Studies and Diet
- Respiratory viral infections research
- Magnesium in Health and Disease
- Environmental Impact and Sustainability
- Cardiovascular Disease and Adiposity
- School Health and Nursing Education
- Dermatology and Skin Diseases
Biomedical Research Institute of Lleida
2020-2024
Instituto de Salud Carlos III
2019-2023
Universidad de Extremadura
2022
University of Buenos Aires
1968-2020
Hospital de Clínicas "José de San Martín"
2020
Fundació Clínic per a la Recerca Biomèdica
2014
Consejo Superior de Investigaciones Científicas
2013
BACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic kidney disease (CKD) and associated with the higher morbidity-mortality patients CKD. VDR (vitamin D receptor) has been proposed to play role in osteoblastic differentiation vascular smooth muscle cells (VSMCs), but involvement vitamin VC CKD controversial. Our aim was determine local signaling VSMCs during CKD-induced VC. METHODS: We used epigastric arteries from CKD-affected individuals normal renal...
Classical risk factors of atherosclerosis in the general population show paradoxical effects chronic kidney disease (CKD) patients. Thus, low low-density lipoprotein (LDL) cholesterol levels have been associated with worse cardiovascular outcomes. Magnesium (Mg) is a divalent cation whose homeostasis altered CKD. Furthermore, Mg health. The present study aims to understand relationships and lipid parameters In this analysis, 1754 participants from Observatorio Nacional de Atherosclerosis en...
The prevalence of allergic diseases and drug hypersensitivity reactions (DHRs) during recent years is increasing. Both, DHRs seem to be related an interplay between environmental factors genetic susceptibility. In years, a large effort in the elucidation mechanisms involved these disorders has been made, mostly based on case-control studies, typically focusing isolated SNPs. These studies provide limited amount information, which now can greatly expanded by complete coverage that Next...
Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy stings. In order increase the existing knowledge on underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, group 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year BVIT. addition, results treated with those an untreated tolerant beekeepers (TG) who had previously shown firm...
Acetaminophen (paracetamol) is a widely used drug that causes adverse events are often dose-dependent and related to plasma concentrations. metabolism strongly depends on UGT1A enzymes. We aimed investigate putative factors influencing acetaminophen pharmacokinetics. analyzed pharmacokinetics after intravenous administration in 186 individuals, we determined the effect of sex; body mass index (BMI); previous concomitant therapy with substrates, inhibitors, inducers; as well common variations...
Cross-hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) is a relatively common, non-allergic, adverse drug event triggered by two or more chemically unrelated NSAIDs. Current evidence point COX-1 inhibition as one of the main factors in its etiopathogenesis. Evidence also suggests that risk dose-dependent. Therefore it could be speculated individuals with impaired NSAID biodisposition might at increased developing cross-hypersensitivity We analyzed common functional gene...
Abstract Background and Aims Vascular calcification (VC) is a highly prevalent complication of chronic kidney disease (CKD) associated with the higher morbidity-mortality patients CKD. Vitamin D receptor (VDR) has been proposed to play role in osteoblastic differentiation vascular smooth muscle cells (VSMCs), but involvement vitamin (1, 25D) VC CKD controversial. Accumulating evidence points microRNAs as important players process recent studies show that miR-145a expression decreases VSMCs...
Although European guidelines recommend vascular ultrasound for the assessment of cardiovascular risk in low-to-moderate individuals, no algorithm properly identifies patients who could benefit from it. The aim this study is to develop a sex-specific identify those patients, especially women are usually underdiagnosed.
<p class="primres">El análisis estructural en un contexto Input Output, y cualquier modelo que relaciona variables endógenas con exógenas, sirve como paso previo para simular predecir alternativas el tiempo o espacio. La utilización de una Tabla Interregional, configurada diversas matrices coeficientes intrarregionales e interregionales recogen los flujos comercio entre regiones sectores, hace sea posible abordar espacial estas interrelaciones.<br />El objetivo éste trabajo es...
We have performed an epidemiological analysis of adult patients hospitalized with influenza A/H1N1 in the year 2009 Pulmonology Service La Paz University Hospital Madrid, Spain. carried out a retrospective cohort and descriptive study from July to December 102 diagnosed Influenza A first 24 h their stay Emergency Unit. All included this were those who admitted Service. did not include died Intensive Care Unit (ICU).There 45 women (44.12%) 57 men (55.88%) mean age 41.40 ± 1.67 years. The days...
La diabetes no es una enfermedad innocua y su presencia se liga íntimamente a sus complicaciones específicas las primeras causas de mortalidad, tales como patologías cardiovasculares.Estos factores -la alta prevalencia la historia natural misma- han sido el motor primordial para que autoridades sanitarias industria farmacéutica traten encontrar medidas útiles prevención tratamiento esta patología.