A5065317886- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- CAR-T cell therapy research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pharmacological Effects and Toxicity Studies
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Multiple Myeloma Research and Treatments
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Muscle and Compartmental Disorders
- Herpesvirus Infections and Treatments
- Complement system in diseases
- Cancer Immunotherapy and Biomarkers
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Chronic Myeloid Leukemia Treatments
- Healthcare and Venom Research
- Immunodeficiency and Autoimmune Disorders
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Hematopoietic Stem Cell Transplantation
- Insect and Pesticide Research
- Eosinophilic Disorders and Syndromes
Instituto Maimónides de Investigación Biomédica de Córdoba
2014-2023
University of Córdoba
2007-2023
Hospital Universitario Reina Sofía
1989-2023
Biomedical Research Institute
2020
Cordoba University
1990-2011
Sofia University "St. Kliment Ohridski"
2001
Cytomegalovirus (CMV) latent infection has a deleterious effect on the efficacy of influenza vaccination in elderly, suggesting that CMV restricts immunological diversity impairing immune system functionality old age. Polyfunctional T cells produce multiple cytokines and higher amounts than mono-functional cells. High number polyfunctional correlates with better prognosis during infection. Thus, efficiency cell response associates quality (polyfunctionality) rather quantity (percentage...
Abstract Background Ageing is associated with changes in the immune system substantial alterations T-lymphocyte subsets. Cytomegalovirus (CMV) one of factors that affect functionality T cells and differentiation large expansions CMV pp65-specific have been impaired responses to other challenges. Moreover, presence clonal CMV-specific may shrink available repertoire for antigens contribute increased incidence infectious diseases elderly. In this study, we analyse effect ageing on phenotype...
Background: Acute myeloid leukemia (AML) remains a major clinical challenge due to poor overall survival, which is even more dramatic in elderly patients. TIGIT, an inhibitory receptor that interacts with CD155 and CD112 molecules, considered as checkpoint T NK cell activation. This shares ligands the co-stimulatory DNAM-1 TACTILE. The aim of this work was analyze expression DNAM-1, TIGIT TACTILE cells subsets AML Methods: We have studied 36 patients at time diagnosis 20 healthy volunteers....
Abstract The susceptibility to natural killer (NK) cell‐mediated cytotoxicity of 20 cell lines obtained from human solid tumors and their class I histocompatibility antigen (HLA) levels were studied in an attempt determine whether major complex (MHC) products expressed on cells derived influence NK susceptibility. effect interferon‐γ (IFN‐γ) treatment these elements was also analyzed. MHC (HLA‐ABC, HLA‐A HLA‐B) degree lysis very heterogeneous no correlation found comparison. After with IFN‐γ...
The consolidation of single antigens beads (SAB-panIgG) assay in the detection preformed anti-HLA antibodies has improved transplantation success. However, its high sensitivity limited allograft allocation for sensitized patients, increasing their waiting time. A modification standard SAB-panIgG allows that sub-set capable binding C1q (SAB-C1q assay). clinical usefulness SAB-C1q determining unacceptable mismatches is under discussion. We retrospectively analyzed impact donor-specific (DSA)...
Humoral alloimmunity, particularly that triggered by preformed antibodies against human leukocyte antigens (HLA), is associated with an increased prevalence of rejection and reduced transplant survival. The high sensitivity solid phase assays, based on microbeads coated single (SAB), consolidated them as the gold-standard method to characterize anti-HLA antibodies, ensuring a successful allograft allocation. Mean fluorescence intensity (MFI) provided SAB regularly used stratify immunological...
Inducing tolerance in Hymenoptera-allergic patients, bee venom immunotherapy (BVIT) is a widely accepted method to treat severe allergy stings. In order increase the existing knowledge on underlying immunological mechanisms and look for possible biomarkers predictive of efficacy, group 20 bee-venom-allergic patients (AG) were thoroughly examined during their first year BVIT. addition, results treated with those an untreated tolerant beekeepers (TG) who had previously shown firm...
Abstract Background Acute kidney injury (AKI) occurs in 12–20% of multiple myeloma (MM) patients. Several studies have shown a reduction free light chains (FLC) using hemodialysis with High-Cut-Off membranes. However, this technique entails albumin loss. Hemodiafiltration ultrafiltrate regeneration is that includes process adsorption. The aim study was to evaluate the effectiveness hemodiafiltration reducing FLC levels without causing Methods This an observational (2012 2018) including nine...
Natural killer (NK) cells are a very important component of the innate immune response involved in lysis virus infected and tumor cells. Aging has profound impact frequency, phenotype function NK Chronic Myeloid Leukemia (CML) caused by BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with kinase inhibitors (TKIs) induces durable deep molecular response. The to treatment life expectancy is lower older patients chronic phase CML than younger patients. In this...
Immunosenescence affects innate and adaptive immunity impairing the response to pathogens vaccines. Chronic infection with cytomegalovirus (CMV) has been shown drive "early immunosenescence" can considerably affect both function phenotype of immune cells, especially T cells. We have previously that expression CD57, CD300a, CD161 was differentially affected by age chronic CMV infection, indicating these markers are a hallmark T-cell aging. The aim this present study clarify whether 3 define...