A5083916876- Dyeing and Modifying Textile Fibers
- Textile materials and evaluations
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Surfactants and Colloidal Systems
- Vasculitis and related conditions
- Skin Protection and Aging
- Advanced Cellulose Research Studies
- Autoimmune Neurological Disorders and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Muscle and Compartmental Disorders
- Inflammatory Myopathies and Dermatomyositis
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Diseases and Immunity
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
Health Research Institute of the Balearic Islands
2016-2024
Hospital Universitario Son Espases
2012-2024
Hospital Clínic de Barcelona
2024
Universitas Gadjah Mada
2019
Centro de Investigación Biomédica en Red
2017
Centre for Biomedical Network Research on Rare Diseases
2017
Universitat de Barcelona
2017
Hospital Sant Joan de Déu Barcelona
2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2017
Hospital Universitario Son Dureta
1998-2010
To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA (GABAAR) encephalitis.Clinical study of 26 patients, including 17 new (April 2013-January 2016) 9 previously reported patients. Antibodies to α1, β3, γ2 subunits GABAAR were determined using techniques.Patients' median age was 40.5 years (interquartile range 48.5 [13.75-62.35] years; youngest 2.5 months old; 13 female). Symptoms included seizures (88%), alteration cognition...
Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD.This study investigates prevalence circulating antinuclear antibodies (ANA) and anti-tissue (AT) antibodies, two common markers autoimmunity, in COPD their relationship with several components disease.We determined lung function, serum titers ANA AT by immunofluorescence, levels C-reactive protein (CRP) high sensitivity nephelometry 328 patients clinically stable...
Behcet's disease (BD) is an immuno-mediated vasculitis in which knowledge of its etiology and genetic basis limited. To improve the current knowledge, a analysis performed with Immunochip platform was carried out population from Spain. A discovery cohort comprising 278 BD cases 1,517 unaffected controls were genotyped using platform. The validation step on independent replication composed 130 600 additional controls. strongest association signals observed HLA class I region, being HLA-B*51...
Low temperature plasma treatments of wool modify only the cuticle surface fibers, improving their wettability, dyeability, fiber cohesion, and shrink resistance. The shrink-resist properties obtained with treatment do not impart a machine-washable finish, which is an important end-user demand. However, resistance air plasma. treated suitably enhanced by subsequent biopolymer chitosan application. Using qualitative colorimetric method, adsorption shown to increase after SEM observations yield...
Cases of narcolepsy in association with psychotic features have been reported but never fully characterized. These patients present diagnostic and treatment challenges may shed new light on immune associations schizophrenia.Our case series was gathered at two specialty centers over a 9-year period. A questionnaire created to improve diagnosis schizophrenia or another disorder narcolepsy. Pathophysiological investigations included full HLA Class I II typing, testing for known systemic...
Behçet's disease (BD) is an immune-mediated systemic disorder with a well-established association HLA class I and other genes. BD has clinical overlap many autoinflammatory diseases (AIDs). The aim of this study was to investigate the role rare variants in seven genes involved AIDs: CECR1, MEFV, MVK, NLRP3, NOD2, PSTPIP1 TNFRSF1A using next generation sequencing (NGS) approach 355 patients. To check global each gene, 4 tests: SKAT, CollapseBt, C(α) weighted KBAC were used. Databases: 1000...
Abstract This study examines in detail the influence of low‐temperature plasma and biopolymer chitosan treatments on wool dyeability. Wool knitted fabrics were treated characterized by whiteness shrink‐resistance measurements. Surface modification was assessed contact‐angle measurements human hair fibers, which used as a model to wetting properties fabrics. The dyeing behavior from diffusion mechanism point view. kinetics measured at two different pHs (4.2 6.5) three temperatures (60, 85,...
Sulfitolysis of wool keratin is important to many industrial processes, including shrink resistance, setting, and bleaching; its extent therefore requires rapid estimation. Currently, time consuming chemical analysis used convert the cysteine-S-sulfonate cysteine then measure total colorimetricaily. Using ftir attenuated reflectance (atr) method, our experiments quantify relative amount on fiber surface. The (Bunte salt) shows a strong symmetrical stretching vibration at 1022 cm −1 ; working...
Chronic obstructive pulmonary disease (COPD) is characterised by an excessive inflammatory response to inhaled particles, mostly tobacco smoking. Although inflammation present in all smokers, only a percentage of them develop COPD. T-lymphocytes are important effector and regulatory cells that participate actively the They comprise T-cell receptor (TCR)-αβ (CD4+ CD8+) TCR-γδ T-lymphocytes. The latter represent small total population, but play key role tissue repair mucosal homeostasis. To...
Summary Common variable immunodeficiency disease (CVID) is a heterogeneous syndrome characterized by low immunoglobulin serum levels and recurrent bacterial infections. Several studies suggest that CVID patients have polarized immune response towards T helper type 1 phenotype (TH1). However, the factors causing TH1 polarization remain to be determined in this disease. In present study, interleukin (IL)-12, interferon (IFN)-γ IL-12p40 IFN-γ gene were studied patients. Furthermore, we evaluate...
Abstract Behçet’s disease (BD) is an immune-mediated systemic disorder with a well-established genetic base. In previous study, using next generation sequencing approach, we found many rare variants and some functional polymorphisms in genes related to autoinflammatory syndromes (AID): CECR1 , MEFV MVK NLRP3 NOD2 PSTPIP1 TNFRSF1A our BD cohort. Our strategy did not allow us establish either number of patients variants, proportion individuals accumulating them or relationship other factors....
Abstract There is no established treatment for progressive IgA nephropathy refractory to steroids and immunosuppressant drugs (r-IgAN). Interleukin 17 (IL-17) blockade has garnered interest in immune-mediated diseases involving the gut-kidney axis. However, single IL-17A inhibition induced paradoxical effects patients with Crohn’s disease some cases of de novo glomerulonephritis, possibly due complete Th1 cell response, along concomitant downregulation regulatory T cells (Tregs). Seven...
Incorporating an enzyme in the alkaline peroxide treatment bath enhances wool wet-tability and effectiveness of subsequently applied chitosan biopolymer. Wool whiteness is also significantly enhanced. knitted fabric thus treated shrink resistant at machine-washable level, which one most important end-user demands. The formation ionic bonds between new sulphonic groups generated on fiber surface contribute to resistance H 2 O + enzyme/chitosan wool. As a result excessive increases...
Abstract The aetiology of Behçet's disease (BD) is still unknown, but genetic and environmental factors are involved. HLA‐B*51 considered a susceptibility marker some MICA alleles have also been associated. Cytotoxic T lymphocytes suggested as responsible for BD lesions by engaging through NKG2D surface molecules. In the present study, HLA‐B were typed polymerase chain reaction using sequence‐specific primers, in 165 healthy Spanish controls 42 patients. group, MICA*008 (28.48%), MICA*004...
Behçet´s disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger in genetically predisposed individuals. HLA-B51 genetic factor stronger associated with disease, although bases of this association remain elusive. NK cells have also been implicated etiopathogenesis BD. A family receptors, Killer-cell Immunoglobulin-like Receptor (KIR), a very complex organization, important...
Background: Emerging evidence suggests that SARS-CoV-2 infection and vaccines may trigger autoimmune responses in predisposed individuals. Idiopathic inflammatory myopathies (IIMs) are diseases with diverse clinical manifestations, often associated myositis autoantibodies (MAs). Diagnosing IIM is challenging due to limitations classification criteria diagnostic assays. This study aimed describe the incidence of following or vaccination compare rates between exposures. Methods: A multicenter...
Chitosan application to wool is known be associated with problems such as its weak binding and uneven distribution. In an attempt overcome problems, chitosan was applied from a mixture nonionic surfactant. A time interaction observed between the surfactant over time, resulting in changes conformation of solution, which confirmed by viscosity measurements. The presence chitosan/surfactant association improved wool, assessed dyeing treated reactive dye at 60°C. Since this technique offers...
Wool fabrics were treated with the biopolymer chitosan under conditions which conferred shrinkresistance and dyeing improvement. In order to enhance absorption in wool, two different oxidative chemical pretreatments, hydrogen peroxide permonosulphuric acid, performed on wool prior application. Chitosans of three molecular masses, but same acetylation degrees of, applied unpretreated oxidated influence mass pretreatment shrink‐resistance behaviour was assessed. conclusion, both exert an...
Abstract A comparative study on physical‐chemical as well antimicrobial properties of salts Nα‐Lauroyl‐L‐α, ω dibasic aminoacids esters containing a) Nω‐amino, b) Nω‐guanidino or c) Nω‐trimethyl amino groups, have been carried out systematically. The Nω, Nω trimethyl acids derivatives synthesized by the reaction a Nα‐Lauroyl‐L‐Lysine ester with combination methyl Iodide/potassium bicarbonate/methanol, being this ternary mixture mild and very efficient media for quaternization these modified...
Autoantibody detection is the cornerstone of autoimmune liver diseases (AILD) diagnosis. Standardisation working algorithms among autoimmunity laboratories, as well being aware sensitivity and specificity various commercial techniques in daily practice, are still necessary. The aim this nationwide study to report results 2020 Autoimmunity Workshop organised by Group Spanish Society Immunology provide useful information clinicians laboratory specialists improve management autoantibody AILD...