A5010402782- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Celiac Disease Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Blood Coagulation and Thrombosis Mechanisms
- Inflammasome and immune disorders
- Food Allergy and Anaphylaxis Research
- Long-Term Effects of COVID-19
- Pediatric Hepatobiliary Diseases and Treatments
- Oral Health Pathology and Treatment
- Parvovirus B19 Infection Studies
- Blood disorders and treatments
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Sarcoidosis and Beryllium Toxicity Research
Hospital Clínic de Barcelona
2021-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2024
Universitat de Barcelona
2021-2024
Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included classification criteria lupus anticoagulant (LA) IgG IgM isotypes anticardiolipin (aCL) anti-beta-2 glycoprotein I (β2GPI) antibodies. Non-classification markers such as autoantibodies that recognize phosphatidylserine/prothrombin (aPS/PT) complex have been proposed biomarkers for APS. Studies aPS/PT antibodies shown strong correlation clinical...
Patients with COVID-19 presented an elevated prevalence of antiphospholipid antibodies (aPL) but the relationship thrombosis is controversial. We analysed persistence aPL and their association clinical outcomes during hospitalisation in a cohort patients.We conducted prospective study including consecutive hospitalised patients from Hospital Clínic Barcelona between March 28th April 22nd, 2020. Clinical were thrombosis, intensive care unit (ICU) admission, severe ventilatory failure....
To assess the effect of average adjusted global APS score (aGAPSS) over time on recurrence clinical manifestations in patients through a retrospective longitudinal study.The study included 200 with APS. The aGAPSS was calculated for each patient at baseline and yearly basis either up to 6 years (minimum 3 years) or just before event who experienced recurrence. mean per computed. In under vitamin K antagonists (VKA) percentage spent within therapeutic range (TTR) calculated. Cox regression...
Autoantibody detection is the cornerstone of autoimmune liver diseases (AILD) diagnosis. Standardisation working algorithms among autoimmunity laboratories, as well being aware sensitivity and specificity various commercial techniques in daily practice, are still necessary. The aim this nationwide study to report results 2020 Autoimmunity Workshop organised by Group Spanish Society Immunology provide useful information clinicians laboratory specialists improve management autoantibody AILD...
Anti-dsDNA autoantibodies quantification and complement levels are widely used to monitor disease activity in systemic lupus erythematosus (SLE). However, better biomarkers still needed. We hypothesised whether the dsDNA antibody-secreting B-cells could be a complementary biomarker prognosis of SLE patients. Fifty-two patients were enrolled followed for up 12 months. Additionally, 39 controls included. An cut-off (comparing active non-active according clinical SLEDAI-2K) was established...
Anti-dsDNA, anti-Sm, and anti-ribosomal-P autoantibodies are hallmarks of systemic lupus erythematosus (SLE), being anti-dsDNA anti-Sm included in 2019-ACR/EULAR SLE-Classification Criteria. Enzyme-linked (ELISA) chemiluminescence assays (CIA) widely established immunology laboratories, but new technologies, such as particle-based multi-analyte technology (PMAT), nowadays available. The present study aimed to compare the presence measured by CIA PMAT analyze diagnostic clinical SLE activity...
Background: The clinical and laboratory features of patients with non-criteria obstetric antiphospholipid syndrome (NC-OAPS), as well their pregnancy outcomes ideal treatment are not clearly determined. aim this study is to describe the characteristics pregnancies in NC-OAPS compare them an APS (OAPS) cohort. Methods: Retrospective conducted a cohort women referred high-risk unit tertiary hospital. Women that were classified having OAPS or included compared terms characteristics, management,...
Background: The clinical and laboratory features of patients with non-criteria obstetric antiphospholipid syndrome (NC-OAPS), as well their pregnancy outcomes ideal treatment are not clearly determined. aim this study is to describe the characteristics pregnancies in NC-OAPS compare them an APS (OAPS) cohort. Methods: This a retrospective conducted on cohort women referred high-risk unit tertiary hospital. Women that were classified having OAPS or included compared terms characteristics,...
M2-type anti-mitochondrial autoantibodies are considered the hallmark of primary biliary cholangitis and directed mainly against E2 subunits 2-oxo acid dehydrogenase complex enzymes (PDC, BCOADC OGDC). The aim this study was to determine whether a Dot-blot that includes these separately could confirm results methods with non-separated in patients low positive or discordant between techniques.Sera 24 10 clear by were analyzed separated subunits.Autoantibodies PDC, OGDC detected all patients,...
<h3>Background</h3> Interstitial lung disease (ILD) is one of the leading causes morbidity and premature mortality in rheumatoid arthritis (RA) patients. Some studies have shown that Krebs von den Lungen-6 (KL-6) may be a valuable biomarker for diagnosis stratifying prognosis Rheumatoid Arthritis-Associated Lung Disease (RA-ILD). <h3>Objectives</h3> To evaluate diagnostic prognostic value serum KL-6 RA-ILD <h3>Methods</h3> We conducted retrospective study included patients with RA (ACR/EULAR...
<h3>Background</h3> Systemic Sclerosis (SSc) is an autoimmune disease characterized by excessive fibrosis, inflammation and vasculopathy of the skin internal organs. Interstitial lung (ILD) most important cause mortality. Multiple autoantibodies (Abs) against nuclear proteins are present in >95% patients. Anti-Topoisomerase-I (ATA), anti-CENP-B (ACA) anti-RNA-polymerase-III (RNAP3) Abs included 2013 SSc ACR/EULAR classification criteria. The detection additional interest to identify...
<h3>Background</h3> Some studies have shown that Krebs von den Lungen-6 (KL-6) may be a valuable biomarker for diagnosis and stratifying prognosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD). Citrullination carbamylation are responsible generating Anti-Modified Protein/Peptide Antibodies (AMPAs) associated with RA-ILD. <h3>Objectives</h3> To evaluate the correlation between serum KL-6 AMPAs patients RA. <h3>Methods</h3> We conducted cross-sectional study included RA...