A5002609265- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Dermatologic Treatments and Research
- Inflammatory Myopathies and Dermatomyositis
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Skin Diseases and Diabetes
- Intensive Care Unit Cognitive Disorders
- Ocular Diseases and Behçet’s Syndrome
- Endometriosis Research and Treatment
- Listeria monocytogenes in Food Safety
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Otitis Media and Relapsing Polychondritis
- Chronic Kidney Disease and Diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Parvovirus B19 Infection Studies
- Lymphatic System and Diseases
- Respiratory Support and Mechanisms
- Inflammasome and immune disorders
- Cutaneous Melanoma Detection and Management
Hospital Clínic de Barcelona
2020-2024
Universitat de Barcelona
2021-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2023
Hospital Universitario Puerta de Hierro Majadahonda
2013-2019
Some COVID-19 survivors present lung function abnormalities during follow-up, particularly reduced carbon monoxide diffusing capacity (DLCO). To investigate risk factors and underlying pathophysiology, we compared the clinical characteristics levels of circulating pulmonary epithelial endothelial markers in with normal or DLCO 6 months after discharge.
Treatment with direct-acting antivirals (DAA) eradicates hepatitis C virus (HCV) from most chronic carriers. Information on regression of liver fibrosis and the influence HIV is scarce in cured patients.All consecutive HCV-infected individuals treated DAA at our institution were examined. Hepatic elastography was performed baseline time SVR12. Liver defined as a shift advanced (Metavir F3-F4) to null-mild (F0-F2) and/or reduction greater than 30% kPa. AST platelet ratio index (APRI) 4...
Background Cure rates above 90% have been reported in most Phase III clinical trials using distinct all-oral direct-acting antivirals (DAAs) chronic hepatitis C patients. Preliminary results real-world patients confirmed this, although efficacy tends to be lower. Methods All consecutive treated with DAA regimens at three clinics Spain were retrospectively examined. Host and viral factors tested as predictors of treatment failure. Results A total 363 had completed a course therapy outside up...
Abstract Objectives EULAR supports the use of nailfold videocapillaroscopy (NVC) for identifying disease patterns (DPs) associated with SSc and RP. Recently, proposed an easy-to-manage procedure, a so-called Fast Track algorithm, differentiating from non-SSc in NVC specimens. However, subjectivity among capillaroscopists remains limitation. Our aim was to perform software-based analysis peculiarities cohort samples RP patients and, subsequently, build Track–inspired algorithm DPs without...
Abstract Objective This research aims to study structural brain changes in patients with persistent olfactory dysfunctions after coronavirus disease 2019 (COVID‐19). Methods COVID‐19 were evaluated using T1‐weighted and diffusion tensor imaging (DTI) on a 3T MRI scanner, 9.94 ± 3.83 months diagnosis. Gray matter (GM) voxel‐based morphometry was performed FSL‐VBM. Voxelwise statistical analysis of the fractional anisotropy, mean diffusivity (MD), radial (RD), axial carried out tract‐based...
Oral and genital ulcers are the hallmark manifestation of Behçet's disease (BD), significantly impacting patients' quality life. Our study focuses on comparing effectiveness safety TNF inhibitors (TNFis) apremilast in controlling oral BD, aiming to provide evidence-based guidance for physicians selecting appropriate treatment modalities.
Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence resistance‐associated substitutions (RAS) at baseline has occasionally been associated with impaired response. Herein, we examined impact RAS HCV NS5A gene region on response in a real‐life setting. All C patients treated including inhibitors our institution were retrospectively examined. The virus was analyzed using population sequencing and after 24 weeks completing therapy all that failed. changes...
Most individuals fully recover after suffering coronavirus disease 2019 (COVID-19), but a subset of patients present persistent post-disease abnormalities, including: 1) long COVID, defined as the persistence (>2 months) symptoms 3 months onset COVID-19 that cannot be explained by an alternative diagnosis [1]; and 2) chronic pulmonary sequelae , abnormal lung function and/or structure [2–5]. Footnotes This manuscript has recently been accepted for publication in ERJ Open Research . It is...
Monitoring of disease activity in sclerosing dermatoses (SD) can be challenging and tools to support clinical decision-making are lacking.To analyse the impact high-frequency ultrasonography (HFUS) on management SD describe US characteristics activity.This was a cohort study patients with various [morphoea, systemic sclerosis (SS) chronic graft-versus-host (cGvHD)] who underwent HFUS between January 2017 August 2019. criteria for diagnosing active were increased Doppler vascularity and/or...
Pregnancy in systemic sclerosis (SSc) patients is no more an infrequent event as it used to be, but literature data on pregnancy outcomes women with SSc are scarce. The rate of preterm deliveries and intrauterine growth restriction (IUGR) seems be increased, while the risk miscarriages controversial. Moreover, study compared antiphospholipid syndrome (APS) lupus erythematosus (SLE). We performed a retrospective compare disease cohort age-matched (SLE), (APS), healthy controls (HC).A total...
Abstract Introduction Endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i) are beneficial in pulmonary arterial hypertension (PAH) digital ulcers (DU) prevent from DU recurrences. Our study aimed to determine the difference incidence rate of PAH scleroderma renal crisis (SRC) patients with SSc (SSc-DU) under ERAs/PDE5i or without treatment. Methods We conducted a retrospective cohort including SSc-DU Spanish Scleroderma Registry (RESCLE). The primary outcome was...
To map existing organizational care pathways in clinical centers of expertise that for pregnant women affected by rare and complex connective tissue diseases (rcCTDs).An international working group composed experts the field pregnancy rcCTDs co-designed a survey focused on aspects related to patient's pathway before, during, after pregnancy. The was distributed subject through referral sampling.Answers were collected from 69 21 countries. Patients with systemic lupus erythematosus and/or...
Anti-dsDNA autoantibodies quantification and complement levels are widely used to monitor disease activity in systemic lupus erythematosus (SLE). However, better biomarkers still needed. We hypothesised whether the dsDNA antibody-secreting B-cells could be a complementary biomarker prognosis of SLE patients. Fifty-two patients were enrolled followed for up 12 months. Additionally, 39 controls included. An cut-off (comparing active non-active according clinical SLEDAI-2K) was established...
Introduccion. Listeria monocytogenes es la tercera causa en frecuencia de meningitis bacteriana comunitaria adultos. Objetivos. Describir las caracteristicas por (ML) adultos y compararlas con otras etiologias (MnL). Pacientes metodos. Analisis retrospectivo una serie casos hospitalaria, incluyendo pacientes edad >= 14 anos diagnosticados ML un hospital referencia entre 1982 2011. Resultados. Se incluyen 16 ML, el 12,1% comunitarias etiologia identificada. Los factores predisponentes fueron...
Chronic hepatitis C virus (HCV) infection is one of the major causes death worldwide due to infectious agents. The advent direct-acting antivirals has dramatically improved chance HCV elimination, even for patients with decompensated cirrhosis. Along cure, benefits are recognized in terms regression liver fibrosis and risk hepatocellular carcinoma. Furthermore, beyond hepatic outcomes, several extrahepatic may result from sustained eradication, including improvements neurocognitive function...
<h3>Background:</h3> Nailfold capillaroscopy is a non-invasive, cost-effective, and well-established examination used to diagnose various systemic autoimmune diseases support patient follow-up. Although its clinical significance acknowledged, the challenge of subjectivity remains notable obstacle, impeding progress in both research diagnosis. The categorisation three scleroderma patterns established by Cutolo et al adds objectivity analysis, although boundaries between different can be...
<h3>Background:</h3> Although the diagnostic and prognostic value of capillaroscopy is indisputable, it still a technique with great heterogeneity both in its performance interpretation. With regard to performance, several studies support exhaustive analysis 8 mm as sufficient subset obtain valid diagnosis, but clinical practice we find very different fields within same capillaroscopy. New tools, such artificial intelligence, make possible perform systematic entire nail bed quickly,...