A5019937532- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Sleep and Wakefulness Research
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Memory and Neural Mechanisms
- Inflammation biomarkers and pathways
- Cardiovascular Health and Disease Prevention
- Retinal Imaging and Analysis
- Electrolyte and hormonal disorders
- Studies on Chitinases and Chitosanases
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2023-2024
Universitat de Barcelona
2007-2023
Hospital Mare de Déu de la Mercè
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2007-2022
Fundació ACE
2007-2021
Fidmag Sisters Hospitallers
2011-2021
Centro de Investigación Biomédica en Red de Salud Mental
2010-2021
Instituto de Salud Carlos III
2020-2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2021
Centro de Investigación Biomédica en Red
2020
Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways.Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study dementia its clinical endophenotypes, defined based on AD's certainty vascular burden. We assessed the known AD loci across endophenotypes to generate categories. incorporated gene coexpression data conducted pathway analysis per category. Finally, evaluate effect heterogeneity in...
The aim of this study was to investigate whether hyponatremia is a risk factor overt hepatic encephalopathy (HE) in cirrhosis.A total 61 patients with cirrhosis were evaluated prospectively for 1 year and all episodes HE recorded. Predictive factors analyzed using conditional model (Prentice, Williams, Peterson) recurrent events assess the relationship between time-dependent covariates. effects on brain concentration organic osmolytes 25 H-magnetic resonance spectroscopy.Twenty-eight...
Abstract Introduction TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) often found abnormally increased cerebrospinal fluid (CSF) Alzheimer's disease (AD). Methods One hundred fourteen participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], 23 AD) underwent CSF sTREM2 determination magnetic resonance imaging (MRI). We studied association between sTREM2, gray matter volume, water motion diffusivity anisotropy...
A relatively large number of studies have investigated the power structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few them also included bipolar disorder, allowing clinically relevant discrimination between both psychotic diagnostics. To assess efficacy sMRI for diagnostic prediction in psychosis we objectively evaluated discriminative a wide range commonly used machine learning algorithms (ridge, lasso,...
Background. The subgenual anterior cingulate cortex (sgACC) is considered to be an important site of abnormality in major depressive disorder. However, structural alterations this region have not been a consistent finding and functional imaging studies also implicated additional areas. Method. A total 32 patients with disorder, currently depressed, 64 controls underwent MRI. Also, 26 52 were examined using magnetic resonance (fMRI) during performance the n -back working memory task....
Objective Brain structural changes in schizoaffective disorder, and how far they resemble those seen schizophrenia bipolar have only been studied to a limited extent. Method Forty‐five patients meeting DSM ‐ IV RDC criteria for groups of with 45 matched healthy controls were examined using voxel‐based morphometry ( VBM ). Results Analyses comparing each patient group the control subjects found that disorder showed widespread overlapping areas significant volume reduction, but did not. A...
Background and Objective: Brain atrophy cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences brain cognition de novo Parkinson's disease (PD) patients. Methods: Clinical, neuropsychological T1-weighted MRI data from 205 PD patients (127 males: 78 females) 69 healthy controls (40 29 were obtained the PPMI dataset. Results: males had a greater motor rapid eye movement sleep behavior disorder symptomatology than females. They also...
<h3>BACKGROUND AND PURPOSE:</h3> There is a paucity of data on long-term neuroimaging findings from individuals who have developed the post-coronavirus 2019 (COVID-19) condition. Only 2 studies investigated correlations between cognitive assessment results and structural MR imaging in this population. This study aimed to elucidate outcomes participants with post-COVID-19 condition correlate these <h3>MATERIALS METHODS:</h3> A cohort 53 underwent 3T brain T1 FLAIR sequences obtained median...
To study metabolic brain changes in preclinical carriers of Huntington disease (PreHD) using proton magnetic resonance spectroscopy (1H-MRS) and to examine their relationship neuropsychological performance.Seventeen subjects with PreHD 17 controls, matched for age education, were studied. Frontal cortex basal ganglia 1H-MRS, a detailed battery, including visuomotor integration speed, memory, frontal, visuospatial tests performed. Statistical analysis included Student t-test Pearson...
Objectives. Manic patients have been found to show reduced activation in the prefrontal cortex and other regions during performance of cognitive tasks. However, little is known about de-activations associated with disorder. This study aimed examine, at whole-brain level, abnormal patterns task-related de-activation a working memory task. Methods. Twenty-nine DSM-IV bipolar 46 healthy controls underwent fMRI n-back The were scanned while they manic episode. Linear models used obtain maps...
Peripheral biomarkers that identify individuals at risk of developing Alzheimer's disease (AD) or predicting high amyloid beta (Aβ) brain burden would be highly valuable. To facilitate clinical trials disease-modifying therapies, plasma concentrations Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. The Fundació ACE Healthy Brain Initiative (FACEHBI) study uses a convenience sample 200 diagnosed with subjective cognitive...
Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along continuum Alzheimer's disease (AD).Brain magnetic resonance imaging (MRI) scans were acquired 110 participants (49 control; 19 preclinical; 27 mild cognitive impairment [MCI] due to AD; 15 AD dementia) CSF concentrations YKL-40 sTREM2...
There is a widespread interest in applying pattern recognition methods to anatomical neuroimaging data, but so far, there has been relatively little investigation into how best derive image features order make the most accurate predictions. In this work, Gaussian Process machine learning approach was used for predicting age, gender and body mass index (BMI) of subjects IXI dataset, as well diagnostic status using ABIDE COBRE datasets. MRI data were segmented aligned SPM12, variety feature...
Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles SCD individuals remain mostly unexplored.We evaluated apolipoprotein E (APOE) ε4's effect in risk presenting SCD, using Fundacio ACE Healthy Brain Initiative (FACEHBI) cohort Spanish controls, performed meta-analysis addressing same question. We assessed relationship between APOE dosage brain amyloid burden FACEHBI Disease...
Visual impairment is common in people living with dementia and regular ophthalmological exams may improve their quality of life. We evaluated visual function a cohort elderly individuals analyzed its association degree cognitive impairment. Participants underwent neurological neuropsychological exams, neuro-ophthalmological assessment (visual acuity, intraocular pressure, rates past pathologies, use ocular correction, treatments surgeries) optical coherence tomography (OCT) scan. differences...
Cognitive impairment in the euthymic phase is a well-established finding bipolar disorder. However, its brain structural and/or functional correlates are uncertain.Thirty-three patients with preserved memory and executive function 28 significant impairment, as defined using two test batteries, Rivermead Behavioural Memory Test (RBMT) Assessment of Dysexecutive Syndrome (BADS), plus healthy controls underwent MRI voxel-based morphometry (VBM). Twenty-seven cognitively patients, 23 impaired...
Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for quantification retinal structural measurements. Multiple studies show that patients with Alzheimer's disease (AD) exhibit thinning in several layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as risk factor progression AD. There little data about changes preclinical AD their correlation amyloid-β (Aβ) uptake. We investigated association thickness quantified by...
The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson's disease (PD), but the impact sex is unclear. We aimed investigate differences cognition PD patients with without probable RBD (pRBD).Magnetic resonance imaging data were obtained for 274 participants from Progression Marker Initiative database: 79 pRBD (PD-pRBD; male/female, 54/25), 126 (PD-non pRBD; 73/53), 69 healthy controls (male/female, 40/29)....
Abstract Objective This research aims to study structural brain changes in patients with persistent olfactory dysfunctions after coronavirus disease 2019 (COVID‐19). Methods COVID‐19 were evaluated using T1‐weighted and diffusion tensor imaging (DTI) on a 3T MRI scanner, 9.94 ± 3.83 months diagnosis. Gray matter (GM) voxel‐based morphometry was performed FSL‐VBM. Voxelwise statistical analysis of the fractional anisotropy, mean diffusivity (MD), radial (RD), axial carried out tract‐based...
The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect deficits in individuals with preclinical Alzheimer's disease (AD). Worse performance on FNAME cognitively healthy were found related higher amyloid beta (Aβ) burden measured Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of Spanish version (S-FNAME) Spanish-speaking subjects. aim the present study was determine whether S-FNAME associated Aβ...
Background: Structural imaging studies of cannabis users have found evidence both cortical and subcortical volume reductions, especially in cannabinoid receptor-rich regions such as the hippocampus amygdala. However, findings not been consistent. In present study, we examined a sample adult heavy without other substance abuse to determine whether long-term use is associated with brain structural changes, regions. Method: We compared grey matter 14 long-term, non-using controls. To provide...