A5011463544- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Biotin and Related Studies
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Toxin Mechanisms and Immunotoxins
- Asthma and respiratory diseases
- Lipid Membrane Structure and Behavior
- Polyamine Metabolism and Applications
- Dermatology and Skin Diseases
- Plant Reproductive Biology
- Biochemical and Structural Characterization
- Polysaccharides and Plant Cell Walls
- Signaling Pathways in Disease
- Antimicrobial Peptides and Activities
- Sphingolipid Metabolism and Signaling
- Gene expression and cancer classification
- Monoclonal and Polyclonal Antibodies Research
Universidad Rey Juan Carlos
2024
Universidad Complutense de Madrid
2017-2021
The Francis Crick Institute
2021
Plant lipid transfer proteins are a large family that can be found in all land plants. They have hydrophobic cavity allows them to harbor lipids and facilitates their traffic between membranes. However, humans, this plant protein is responsible for the main food allergies Mediterranean area. Nevertheless, not only itself but also its ligand relevant allergic sensitization. The aim of present work analyse natural ligands carried by four allergenic LTPs (Tri 14, Art v 3, Par j 2, Ole e 7),...
Olive pollen is a major allergenic source worldwide due to its extensive cultivation. We have combined available genomics data with comprehensive proteomics approach get the annotated olive tree (Olea europaea L.) proteome and define complex allergenome. A total of 1907 proteins were identified by LC–MS/MS using predicted protein sequences from genome. Most (60%) possess catalytic activity be involved in metabolic processes. In total, 203 belonging 47 allergen families found pollen....
Abstract Background Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This nsLTP responsible for severe symptoms in regions with high pollen exposure, where many 7‐sensitized patients exhibit co‐sensitization to peach nsLTP, Pru p 3. However, there no evidence cross‐reactivity, which explains this observed co‐sensitization. Therefore, purpose study was explore relationship between and Methods A total 48 sensitized and/or...
Cross-reactivity reactions between allergenic polygalacturonases (PGs) from different biological sources, especially foods and pollens the Oleaceae family, have been described using Salsola kali PG (Sal k 6). No olive pollen has characterized to date, hampering further knowledge about cross-reactions through PGs.The aim of this work was determine potential allergenicity clarify its role in cross-reactivity.A cDNA-encoding sequence subcloned into pET41b vector used transform BL21(DE3)...
Abstract Olive pollen is a major cause of immunoglobulin E (IgE)-mediated allergy in Mediterranean countries. It expected to become worldwide leading allergenic source because olive cultivation increasing many Ole e 15 belongs the cyclophilin pan-allergen family, which includes highly cross-reactive allergens from non-related plant, animal and mold species. Here, amino acid differences between its weak human homolog PPIA were grafted onto assess contribution specific surface areas...
Cross-reactivity between nonspecific lipid transfer proteins could cause anaphylaxis, further influencing food avoidance and nutrient deficiencies. The one affecting olive pollen (Ole e 7) peach (Pru p 3) may underlie a variety of pollen-food syndromes, though deep molecular analysis is necessary.
Recent studies of Alzheimer's disease (AD) biomarkers have provided clear evidence for the existence a long preclinical phase still poorly defined. Early diagnosis, which has become major issue in AD, seems to be fundamental success design new therapeutic strategies and understand phase. Our work focuses on analysis humoral response AD patients’ sera against altered brain proteins discovery biomarkers, might improve definition phases allow its understanding at molecular level. We screened...