A5103118822- Metal complexes synthesis and properties
- Trypanosoma species research and implications
- Ferrocene Chemistry and Applications
- Research on Leishmaniasis Studies
- DNA and Nucleic Acid Chemistry
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Toxin Mechanisms and Immunotoxins
- Building Energy and Comfort Optimization
- Biochemical and Molecular Research
- Heat shock proteins research
- Plant Virus Research Studies
- Energy Efficiency and Management
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Impact of Light on Environment and Health
- Insect symbiosis and bacterial influences
- Urban Planning and Valuation
- Lysosomal Storage Disorders Research
- Multi-Criteria Decision Making
- Polyamine Metabolism and Applications
- Smart Cities and Technologies
Ajuntament de L’Hospitalet
2020-2025
Tecnológico de Monterrey
2024
Universidad Nacional de Asunción
2024
Fundación Prodintec
2021-2024
University of Córdoba
2021
Instituto Maimónides de Investigación Biomédica de Córdoba
2021
Hospital Universitario Reina Sofía
2021
Instituto de Salud Carlos III
2021
Centro de Biología Molecular Severo Ochoa
1992-2005
Universidad Complutense de Madrid
2005
The synthesis and chemical characterization of three new transplatinum complexes structural formula trans-[PtCl2(amine)(isopropylamine)] (amine = n,n-dimethylamine, propylamine, butylamine), 1−3, are described. Cytotoxicity tests in tumor cell lines sensitive to cis-DDP (Jurkat, Hela, Vero) also overexpressing ras oncogenes resistant (HL-60 Pam 212-ras) show that 1 3 have higher cytotoxic activity than cisplatin. Moreover, these two trans-Pt(II) kill 212-ras cells through apoptosis...
Abstract The DNA thermal stabilizing effect and antitumour properties of two diastereoisomeric cyclopalladiated compounds, Pd 2 [4‐CH 3 O–C 6 H 4 NC(COC 5 )C ] (μ‐OAc) (I II), derived from benzoylbenzylideneimines have been studied. atropisomers containing acetate‐bridged PdL units a folded structure in boat form. results show that both complexes interact with the double helix but compound II stabilizes more than I. It was also observed vitro antiproliferative activity against colon (CX‐1)...
In the present paper we show that in dogs, naturally infected with Leishmania infantum , aqueous humour and cerebrospinal fluid contain anti‐ IgGs specificity of antigen recognition these fluids is similar to sera. We also encephalon cerebellum dogs there a pathological sponge‐like reaction accompanied by neuronal degeneration, mobilization glial cells together accumulation amyloid deposits. The interstitial intravascular deposition antigens choroid plexus suggest animals failure...
Abstract The immune modulatory properties of recombinant antigens Kinetoplasmid membrane protein‐11 (KMP11) and Leishmania homologue receptors for activated C kinase (LACK) in cutaneous leishmaniasis (CL) mucosal (ML) patients were evaluated. mean levels interferon‐γ (IFN‐γ) soluble leishmania antigen (SLA) stimulated peripheral blood mononuclear cells (PBMC) ML CL 5625 ± 2333 pg/ml 4422 3665 pg/ml, respectively. IFN‐γ was not detected cultures with KMP11 or LACK. Interleukin‐10 (IL‐10)...
Kinetoplasmid membrane protein-11 (KMP11) is present in a wide range of trypanosomatids. In the paper, we show that T. cruzi KMP11 gene organized cluster formed by four units arranged head-to-tail tandem manner located on chromosome about 1900 kb. Northern blot analyses indicated steady-state level mature transcripts 0.52 kb high and similar three forms parasite. The mRNAs have half-life 16 h whose strongly downregulated when parasites reach stationary growth phase. sequence presents...
cis-Dichloro(d,l-2,3-diaminopropionate ethyl ester)palladium(II), cis-[Pd(Etdap)Cl2] (I), and cis-dichloro(d,l-2,4-diaminobutyrate cis-[Pd(Etdab)Cl2] (II), were synthesized characterized by elemental analysis, IR spectroscopy, TG-DTA thermal analysis. The equilibrium model log βpqr constants of hydrolytic species I II also investigated potentiometric methods (I = 0.15 M (NaClO4) 37 °C). Aqueous solutions cis-[Pd(Etdaa)(H2O)2](ClO4)2 (Etdaa Etdap (III) or Etdab (IV)) prepared stoichiometric...
ABSTRACT Serological tests with crude or recombinant Leishmania antigens are important tools for the diagnosis of leishmania infection. However, these not markers active visceral leishmaniasis (VL), since antibodies to often observed in individuals subclinical L. chagasi infection and they do fall shortly after therapy. In this study, levels immunoglobulin G (IgG) against three (rH2A, KMP11, “Q” protein) were evaluated sera from patients VL pre- posttherapy. The sensitivity serological test...
Current climate change threats and increasing CO2 emissions, especially from the building stock, represent a context where action is required. It necessary to provide efficient manners manage energy demand in buildings contribute decarbonised future. By combining new technologies, such as artificial intelligence, Internet of things, blockchain, exploitation big data towards solving real life problems, way could be paved smart energy-aware buildings. In this context, aim paper present...
Summary The high variability among strains and isolates of Trypanosoma cruzi the existence shared antigenic determinants with other pathogens, particularly members Leishmania genus make difficult specific diagnosis Chagas' disease. data reported in this paper show that T. KMP11 protein is an immunodominant antigen highly recognized by sera from chagasic leishmaniasis patients. By use amino- carboxyl-terminal truncated recombinant proteins synthetic peptides, evidence provided while patients...
Total-reflection X-ray fluorescence (TXRF), has been applied to a study of DNA platination kinetics calf thymus in vitro, investigating the intercalation sequences three Pt-containing medicines (cis-diamminedichloroplatinum(II) (cis-DDP), Pt-Berenil, and K2PtCl4) DNA. The vivo was focused on introduction process cis-DDP Pt-Berenil HeLa cells. To quantify amount Pt bound DNA, TXRF needs sample volume ≤100 µl. concentrations from 3 30 ng ml–1 were determined with relative standard deviation...
Abstract Molecular epidemiology of circulating clinical isolates is crucial to improve prevention strategies. The Spanish Working Group on multidrug resistant tuberculosis (MDR-TB) a network that monitors the MDR-TB in Spain since 1998. aim this study was present and extensively drug-resistant (XDR-TB) patterns using different recommended genotyping methods over time by national coordinated system. Based proposed European Union until 2018, preservation one method, MIRU-VNTR, applied selected...