A5072963342- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Mind wandering and attention
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Cognitive Functions and Memory
- Neuropeptides and Animal Physiology
- Cognitive Abilities and Testing
- Health, Environment, Cognitive Aging
- Child Development and Digital Technology
- Diverse Music Education Insights
- Reading and Literacy Development
- Neuroscience and Music Perception
- Psychedelics and Drug Studies
- Child Development and Education
- Physical Activity and Health
- Educational Games and Gamification
- Advanced Neuroimaging Techniques and Applications
- Educational Methods and Outcomes
- Digital Mental Health Interventions
- Face Recognition and Perception
Hospital Sant Jaume de Calella
2020-2025
University of California, San Francisco
2017-2024
University of California, Berkeley
2013-2023
National Institute on Drug Abuse
2011-2015
National Institutes of Health
2012
Cognitive training interventions are a promising approach to mitigate cognitive deficits common in aging and, ultimately, improve functioning older adults. Baseline neural factors, such as properties of brain networks, may predict outcomes and can be used the effectiveness interventions. Here, we investigated relationship between baseline network modularity, measure segregation sub-networks, training-related gains cognition We found that adults with more segregated sub-networks (i.e.,...
Recent work suggests that the brain can be conceptualized as a network comprised of groups sub-networks or modules. The extent segregation between modules quantified with modularity metric, where networks high have dense connections within and sparser Previous has shown higher predicts greater improvements after cognitive training in patients traumatic injury healthy older young adults. It is not known, however, whether also predict gains physical exercise intervention. Here, we adults (N =...
Abstract Sustained attention is a critical cognitive ability that improves over the course of development and predicts important real-world outcomes, such as academic achievement. However, majority work demonstrating links between sustained skills has been conducted in lab-based settings lack ecological validity more naturalistic environment, like school. Further, most studies focus on targeted measures specific sub-skills have not fully examined whether this relationship generalizes to...
Rapid, flexible reconfiguration of connections across brain regions is thought to underlie successful cognitive control. Two intrinsic networks in particular, the cingulo-opercular (CO) and fronto-parietal (FP), are two operations critical for control: task-set maintenance/tonic alertness adaptive, trial-by-trial updating. Using functional magnetic resonance imaging, we directly tested whether connectivity CO FP was related demands behavior. We focused on working memory because evidence that...
Abstract Musical instrument training has been linked to improved academic and cognitive abilities in children, but it remains unclear why this occurs. Moreover, access is not always feasible, thereby leaving less fortunate children without opportunity benefit from such training. Although music‐based video games may be more accessible a broader population, research lacking regarding their benefits on performance. To address gap, we assessed custom‐designed, digital rhythm game as proxy for...
Introduction Studies examining sustained attention abilities typically utilize metrics that quantify performance on vigilance tasks, such as response time and variability. However, approaches assess the duration an individual can maintain their over are lacking. Methods Here we developed objective span metric quantified maximum amount of a participant continuously maintained optimal “in zone” state while performing continuous task. Results In population 262 individuals aged 7–85, showed was...
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by profound and immersive sense of physical transcendence alongside rich vivid auditory distortions visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer valuable approach for identifying unique signatures brain activity – linked autonomic physiology naturally unfolding during the altered state...
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition characterized by diminished attentional control. Critically, these difficulties are related to negative consequences in real-life functioning both during development and into adulthood. There now growing evidence that modulating the underlying neural circuits attention can improve behavior brain function children with ADHD. We have previously shown game-based digital therapeutics targeting key marker...
Abstract Preserving attention abilities is of great concern to older adults who are motivated maintain their quality life. Both cognitive and physical fitness interventions have been utilized in intervention studies assess maintenance enhancement seniors, a coupling these approaches compelling strategy buttress both health time- resource-effective manner. With this perspective, we created closed-loop, motion-capture video game (Body-Brain Trainer: BBT) that adapts player’s demands an...
Amnestic mild cognitive impairment (aMCI) is a predementia stage of Alzheimer's disease associated with dysfunctional episodic memory and limited treatment options. We aimed to characterize feasibility, clinical, biomarker effects noninvasive neurostimulation for aMCI. 13 individuals aMCI received eight 60-minute sessions 40-Hz (gamma) transcranial alternating current stimulation (tACS) targeting regions related processing. Feasibility, memory, plasma biomarkers were assessed. Neuroplastic...
Previous reports on the functional effects (i.e., gain or loss of function), and phenotypic outcomes (e.g., changes in addiction vulnerability stress response) a commonly occurring single nucleotide polymorphism (SNP) mu-opioid receptor (OPRM1 A118G) have been inconsistent. Here we examine effect this implicit reward learning. We used probabilistic signal detection task to determine whether impacts response bias monetary 63 healthy adult subjects: 51 AA homozygotes 12 G allele carriers....
The incorporation of game features into cognitive tasks can inform us about the influence reward and motivation on attention. Continuous performance (CPTs), designed to assess attention abilities, are examples that have been targeted for addition features. However, previous results mixed regarding how elements affect abilities task performance.Here, we studied if there were factors predict which individuals exhibit changes in from added a CPT. Participants (N = 94, aged 21-71) played...
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by profound and immersive sense of physical transcendence alongside rich vivid auditory distortions visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer valuable approach for identifying unique signatures brain activity – linked autonomic physiology naturally unfolding during the altered state...
Inattention can negatively impact several aspects of a child's life, including at home and school. Cognitive physical interventions are two promising non-pharmaceutical approaches used to enhance attention abilities, with combined often being marketed teachers, therapists, parents typically without research validation. Here, we assessed the feasibility incorporating an integrated, cognitive-physical, closed-loop video game (body-brain trainer or 'BBT') as after-school program, also evaluated...