A5081310051- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- Genetic Neurodegenerative Diseases
- Cardiomyopathy and Myosin Studies
- Erythrocyte Function and Pathophysiology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cellular transport and secretion
- Antiplatelet Therapy and Cardiovascular Diseases
- Clinical Nutrition and Gastroenterology
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cuban History and Society
- Venous Thromboembolism Diagnosis and Management
- Tuberculosis Research and Epidemiology
- Hepatitis B Virus Studies
- Neuroscience and Neuropharmacology Research
- Cardiovascular Effects of Exercise
- Nosocomial Infections in ICU
- Liver Diseases and Immunity
- Pharmacology and Obesity Treatment
- Public Health and Social Inequalities
- bioluminescence and chemiluminescence research
Hospital El Bierzo
2020-2025
University Hospital of Bern
2023-2024
University of Bern
2021-2024
Hospital Clínic de Barcelona
2010-2021
Universitat de Barcelona
2020-2021
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020-2021
Instituto Venezolano de Investigaciones Científicas
1983-2019
University Hospital of Basel
2013-2016
Hospital Universitario Nuestra Señora de Candelaria
2013-2016
Background — Despite the use of heparin, aspirin, and other antiplatelet agents, acute coronary syndrome patients without ST-segment elevation remain at risk cardiovascular thrombotic events. Given role inflammation in pathogenesis arterial thrombosis, we tested hypothesis that combination meloxicam, a preferential COX-2 inhibitor, heparin aspirin would be superior to alone. Methods Results In an open-label, randomized, prospective, single-blind pilot study, with syndromes were randomized...
Gain-of-function RYR1 mutations cause increased Ca 2+ sparks in vascular smooth muscle cells and prolong bleeding.
Abstract Background and Aims Type 1 long QT syndrome (LQT1) is caused by pathogenic variants in the KCNQ1-encoded Kv7.1 potassium channels, which pathologically prolong ventricular action potential duration (APD). Herein, pathologic phenotype transgenic LQT1 rabbits rescued using a novel KCNQ1 suppression-replacement (SupRep) gene therapy. Methods KCNQ1-SupRep therapy was developed combining into single construct shRNA (suppression) an shRNA-immune cDNA (replacement), packaged...
The protein mammalian target of rapamycin (mTOR) is a serine/threonine kinase regulating number biochemical pathways controlling cell growth. mTOR exists in two complexes termed mTORC1 and mTORC2. Regulatory associated (raptor) with essential for its function. Ablation raptor skeletal muscle results several phenotypic changes including decreased life expectancy, increased glycogen deposits alterations the twitch kinetics slow fibres. In present paper, we show that muscle-specific knockout...
Abstract Molecular epidemiology of circulating clinical isolates is crucial to improve prevention strategies. The Spanish Working Group on multidrug resistant tuberculosis (MDR-TB) a network that monitors the MDR-TB in Spain since 1998. aim this study was present and extensively drug-resistant (XDR-TB) patterns using different recommended genotyping methods over time by national coordinated system. Based proposed European Union until 2018, preservation one method, MIRU-VNTR, applied selected...
Factores de riesgo e impacto clínico los cambios fibróticos y el patrón neumonía organizada en pacientes con síndrome distrés respiratorio agudo producido o no por COVID-19To the Director:2][3][4] Diffuse alveolar damage (DAD)-the most common histological finding in these patients-can develop into a fibroproliferative phase and increase mortality risk. 5,6In several COVID-19 autopsy reports, presence of DAD pattern acute fibrinous organizing pneumonia have been identified. 7Organizing is...
Electromechanical reciprocity - comprising electro-mechanical (EMC) and mechano-electric coupling (MEC) provides cardiac adaptation to changing physiological demands. Understanding electromechanical its impact on function heterogeneity in pathological conditions such as (drug-induced) acquired long QT syndrome (aLQTS) might lead novel insights arrhythmogenesis. Our aim is investigate how electrical changes mechanical vice versa under aLQTS. To measure regional differences EMC MEC vivo, we...
Se presentan los resultados floristicos del estudio sobre liquenes rupicolas que colonizan las pedrizas Parque Nacional de Cabaneros. han identificado 119 especies, cuales 25 se citan por primera vez en el territorio Castilla-La Mancha y otras 36 especies son novedad para la provincia Ciudad Real. En contexto silicicolas identificados peninsular, destacamos su importancia corologica siguientes especies: Acarospora modenensis, Amygdalaria consentiens, Aspicilia inornata, Fuscidea...
Background Skeletal muscle constitutes approximately 40% of body mass, and age-induced decrease strength impinge on daily activities normal social life in the elderly. Loss has been recognised as a debilitating threatening condition also cachexia cancer patients clinical conditions associated with prolonged bed rest. dihydropyridine receptors (Cav1.1) act Ca2+ channels voltage sensors to initiate contraction by activating ryanodine receptors, release sarcoplasmic reticulum. Cav1.1 activity...
Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause acute respiratory distress syndrome (ARDS) pneumonia. ARDS can occur in with community-acquired or nosocomial Data regarding incidence, related pathogens, and specific outcomes VAP limited. This cohort study which were evaluated an 800-bed tertiary teaching hospital between 2004 2016. Clinical outcomes, microbiological epidemiological data assessed among those who...
It is not known whether the occurrence of pulmonary fibrosis higher in patients with COVID-19-induced ARDS than those non-COVID-19-related ARDS. An observational cohort study induced by COVID-19 or other causes. Thoracic radiology was evaluated from day 7 since diagnosis to death ICU discharge. Persistent new-onset opacities, fibrotic-like changes and pattern organizing pneumonia were assessed comparison Factors associated clinical outcomes COVID-19. Twenty-five (47%) 9 (32%)...
<h3>Background</h3> One activity of the Hospital Pharmacist is monitoring and adjustment nutritional support in hospitalised patients. <h3>Purpose</h3> To describe interventions Pharmacy Service Parenteral Nutrition (PN) patients a postoperative intensive care unit. <h3>Material methods</h3> Retrospective six-month study. All pharmaceutical for being treated with TPN were recorded electronic patient medical record an Excel database. <h3>Results</h3> PN was initiated 40 29 cases postsurgical...
<h3>Background</h3> The clinical pharmacist's main functions in parenteral nutrition (PN) are to ensure the appropriate assessment and monitoring of nutritional support according type illness patient's condition verify quality safety solutions prepared. <h3>Purpose</h3> To describe pharmaceutical interventions (PIs) made patients hospitalised a postsurgical intensive care unit. find degree acceptance PIs their relevance patient care. <h3>Material methods</h3> Retrospective six-month study...
<h3>Background</h3> Current clinical practice guidelines for acute coronary syndrome recommend that patients should receive dual antiplatelet treatment with acetylsalicylic acid and an ADP receptor inhibitor 12 months. Today, two novel P2Y12 inhibitors, prasugrel ticagrelor, have been developed offer more effective faster platelet inhibition than clopidogrel. these compounds be used in preference to clopidogrel a wide range of patients. <h3>Purpose</h3> To assess the prescription profile...
<h3>Background</h3> Up until 2014, basiliximab was used in our hospital as an off-label prescription for hepatic transplantation patients whom starting tacrolimus had to be delayed because of their baseline characteristics. Dosage is two 20 mg perfusions (days 0 and +4 after transplantation). The second dose could skipped if the patient has stable renal function. From 2014 onwards, all undergoing received first order delay beginning reduce morbidity hospitalisation time. <h3>Purpose</h3>...