A5086432073- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Mycology
- Immunodeficiency and Autoimmune Disorders
- Influenza Virus Research Studies
- Pharmacogenetics and Drug Metabolism
- Amoebic Infections and Treatments
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Actinomycetales infections and treatment
- Viral gastroenteritis research and epidemiology
- Autoimmune and Inflammatory Disorders
- Enterobacteriaceae and Cronobacter Research
- Pharmacovigilance and Adverse Drug Reactions
- Nephrotoxicity and Medicinal Plants
- Research on Leishmaniasis Studies
- Lung Cancer Diagnosis and Treatment
- Escherichia coli research studies
- Cancer and Skin Lesions
Vall d'Hebron Hospital Universitari
2014-2025
Universitat Autònoma de Barcelona
2005-2025
Hebron University
2015-2025
Vall d'Hebron Institut de Recerca
2017-2025
Instituto de Salud Carlos III
2014-2025
Centro de Investigación Biomédica en Red
2023
Institut Català de la Salut
2017-2022
Hospital Universitari Arnau de Vilanova
2020
Creative Commons
2015
Christie's
2015
A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot NTM species distribution, global partners in NTM-Network European Trials Group (NET) framework ( www.ntm-net.org ), branch Tuberculosis Network (TB-NET), provided identification results total number patients 2008 whom were isolated from pulmonary samples. From these data, we visualised relative different found per continent and country....
<h3>Background</h3> Extended-spectrum β-lactamase (ESBL)-producing<i>Escherichia coli</i>is an increasingly important group of community pathogens worldwide. These organisms are frequently resistant to many the antimicrobial agents usually recommended for treatment infections caused by<i>E coli</i>, such as penicillins, cephalosporins, fluoroquinolones, and trimethoprim-sulfamethoxazole. Data concerning risk factors, clinical features, therapeutic options scarce. <h3>Methods</h3> A...
The effect of interferon-beta in multiple sclerosis is modest and many patients do not respond to treatment. To date, no single biomarker reliably correlates with responsiveness interferon-β sclerosis. In the present study, genome-wide expression profiling was performed peripheral blood mononuclear cells from 47 treated for a minimum 2 years classified as responders non-responders based on clinical criteria. A validation cohort 30 included study replicate gene-expression findings. Before...
This genomic epidemiology study analyzed Mycobacterium bovis and M. caprae isolates from animals humans in Catalonia, Spain, between 2005 2023. Of 42 human tuberculosis (TB) cases, five were phylogenetically linked to livestock outbreaks, suggesting zoonotic transmission. The findings specifically indicate goats as a primary source of transmission humans. also revealed unexpected genetic diversity mycobacteria within the same outbreak or even patient, highlighting complexity dynamics....
Systematic screening of tuberculosis (TB) using molecular testing on stool samples detected TB in 5.2% acutely malnourished children, including cases without evident clinical symptoms. This strategy could enhance diagnosis and facilitate prompt treatment initiation this population. Further studies are required to confirm long-term outcomes cost-effectiveness.
The aim of this article is to describe epidemiological and clinical data patients with tuberculous lymphadenitis (TL) evaluate the yield diagnostic techniques employed. Retrospective observational study was performed at Vall d’Hebron University Hospital, Barcelona, Spain. All adult confirmed TL (microbiologically) or probable (suspected by presentation, cyto/histopathological features, improvement after specific treatment) diagnosed from January 2001 December 2013 were included. One hundred...
Background The aim of our study is to describe the FDG-PET/CT findings in patients with tuberculosis and correlate them patient’s prognosis. Methods We retrospectively collected data from tuberculosis, who had an performed prior treatment initiation 2010 2015. Results Forty-seven out 504 active diagnosis (9.33%) underwent FDG-PET/CT. reasons for performing were: characterization a pulmonary nodule (24; 51.1%), fever unknown origin (12; 25.5%), lymph node enlargement (5; 10.6%) others (6;...
Two strains of Enterobacteriaceae, Escherichia coli and Klebsiella pneumoniae, producing VIM-1 were isolated for the first time in Spain. In both strains, bla(VIM-1) was found to be carried on a gene cassette inserted into class 1 integron. The bla(VIM-1)-containing integron located transferable plasmid.
Most paediatric tuberculosis (TB) cases in low-TB-incidence countries involve children born to migrant families. This may be partially explained by trips their of origin for visiting friends and relatives (VFR). We aimed estimate the risk latent TB infection (LTBI) VFR.
The granule-dependent exocytosis pathway is an important mechanism to induce apoptosis by CD8(+) T cells and NK involves lytic molecules such as perforin. In the current study, we investigated perforin 1 gene (PRF1) a candidate for multiple sclerosis (MS) susceptibility in Spanish population. We genotyped three PRF1 single nucleotide polymorphisms (rs885822, rs10999426, rs3758562) 420 patients with MS 512 controls. Associations of disease were restricted male MS, finding was consistently...
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBLEC) is an increasingly significant cause of community-acquired infection worldwide. The epidemiological features CTX-M- and SHV-producing ESBLEC causing infections are compared. A multicentre cohort study including all caused by in four geographical areas Spain was carried out. ESBL characterization isoelectric focusing, PCR sequencing. Demographics, previous healthcare contact, co-morbidity, use antimicrobials, invasive...
Introduction The QuantiFERON- TB Gold Plus (QFT-Plus) assay, which features two antigen-stimulated tubes (TB1 and TB2) instead of a single tube used in previous-generation interferon-gamma release assays (IGRAs), was launched 2016. Despite this, data regarding the assay’s performance paediatric setting remain scarce. This study aimed to determine QFT-Plus large cohort children adolescents at risk tuberculosis (TB) low-burden setting. Methods Cross-sectional, multicentre healthcare...
Introduction Childhood pulmonary tuberculosis (TB) remains a diagnostic challenge. This study aimed to evaluate the performance of Xpert Ultra for diagnosis TB in children low prevalence setting. Methods Prospective, multicentre, accuracy study. Children with clinical or radiological suspicion were recruited at 11 paediatric units Spain. Up three gastric sputum specimens taken on 3 consecutive days, and analysed by MTB/RIF, culture parallel. Results 86 included (median age 4.9 years, IQR...
Mycobacterium africanum is a cause of tuberculosis (TB) that has mainly been described in Africa, but immigration and travel patterns have contributed to the spread disease other countries.We retrospectively reviewed TB cases due M. during 2000-2010 seven Spanish hospitals. Selected clinical charts were using predefined protocol included demographical, microbiological data outcome.Although 57 diagnosed, only 36 available for review: 82.8% men mean age was 31.6 years (range 12-81). Forty-four...
SUMMARY The overall incidence of spinal tuberculosis (TB) appears to be stable or declining in most European countries, but with an increasing proportion cases the foreign-born populations. We performed a retrospective observational study (1993–2014), including all TB diagnosed at Barcelona hospital assess epidemiological changes. Fifty-four episodes (48·1% males, median age 52 years) were diagnosed. percentage residents increased from 14% 45·2% last 10 years ( P = 0·017). Positive...
Although the Republic of Angola is one 14 countries figuring in three high tuberculosis (TB) burden country lists, true multidrug-resistant TB (MDR-TB) situation unknown.Patients aged 16 years with a diagnosis pulmonary were prospectively enrolled from June 2014 to July 2015. Sputum samples collected for culture and drug susceptibility testing all patients, Xpert® MTB/RIF previously treated patients new whose sputum remained smear-positive after 2 months treatment.A total 422 included;...