A5036980286- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- Botanical Research and Chemistry
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Natural Antidiabetic Agents Studies
- Phytochemical Studies and Bioactivities
- Fungal Biology and Applications
- Plant and Fungal Species Descriptions
- Eicosanoids and Hypertension Pharmacology
- Trypanosoma species research and implications
- Cholinesterase and Neurodegenerative Diseases
- Fatty Acid Research and Health
- Phytochemistry and Bioactive Compounds
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Synthesis of Organic Compounds
- Plant chemical constituents analysis
- Medicinal plant effects and applications
University of Antofagasta
2009-2023
Hospital Clínico San Carlos
2010
University of Chile
1975-2002
Universidad de La Laguna
2002
Universidad Católica del Norte
1997-1999
National University of San Luis
1996
Consejo Superior de Investigaciones Científicas
1990
Centro de Biología Molecular Severo Ochoa
1989
McMaster University
1975-1976
Mohawk College
1975-1976
Antibacterial activity and biotoxicity against Artemia salina of chloroform alcohol extracts isolated products from four plants used in ethnomedicine northern Chile is reported. Nine compounds already identified were aerial parts Artemisia copa Phil., Acantholippia punensis Botta, Ephedra andina Poepp. ex C. A . Mey Haplopappus rigidus Phil : 3,5 dihydroxy 6, 7, 3', 4' tetramethoxyflavone, lupeol, b amyrine , sitosterol, ephedrine, 2 ethylhexanol phthalate 18 acetoxy cis cleroda 3,13 Z...
The antioxidant activities against fish oil oxidation of six commercially available flavonoids and five purified from two Chilean native plants were compared to those dl ‐α‐tocopherol synthetic antioxidants, butylated hydroxytoluene hydroxyanisole. Among the commercial flavonoids, catechin, morin quercetin showed a higher activity when (either spontaneous or Fe 2+ ‐induced) was assessed formation peroxides thiobarbituric acid‐reactive substances. 5,3′,4′‐trihydroxy‐7‐methoxy flavanone...
The antimicrobial activities of aqueous ethanol and chloroform extracts threeBaccharis species currently used in Northern Chile folk medicine for the treatment ofseveral infectious inflammatory disorders were tested against Gram-positive andnegative bacteria fungal spp. using agar-disc diffusion assay. results indicatedthat activity was more pronounced than Gram-negativebacteria yeast. No significant differences on antibacterial observed inthe versus extracts. None plant evaluatedexhibited...
Algesia and inflammation are related with several pathological conditions. It is known that many drugs available for the treatment of these problems cause unwanted side effects. This study was aimed at evaluating acute toxicity anti-inflammatory activity Lampaya medicinalis Phil. (Verbenaceae) widely used in folk medicine Northern Chile against rheumatism, arthritis body joints pain. Oral administration hydroalcoholic extract (HAE) highest dose 3000 mg/ Kg weight resulted no mortalities or...
Lampaya medicinalis Phil. (Verbenaceae) is a plant used by Aymara and Quechua ethnic groups from Northern Chile as folk medicine in the treatment cure of various diseases. The aim this study was to investigate vitro antioxidant activity, total phenols content, flavonoids reducing power, brine shrimp cytotoxicity identify principal chemical constituents.The crude hydroethanolic extract (HEE) its partitioned fraction: hexane (HF), dichloromethane (DF), ethyl acetate (EAF), n-butanol (BF)...
Examination of the alkaloids Lycopodium magellanicum (Palisot de Beauvois) has revealed presence five established structure and a previously unreported alkaloid, magellanine (C 17 H 25 NO 2 ). The ring System magellanine, deduced from an examination its spectroscopic properties, is identical with that paniculatine. been confirmed, relative stereochemistry established, in X-ray crystallographic study.
Seven alkaloids have been isolated from Lycopodium paniculatum Desvaux. Three of these, lycopodine, dihydrolycopodine, and acetyldihydrolycopodine are established structure. Of the four new structure one, paniculatine, has clarified. Its structure, elucidated through an X-ray crystallographic study its hydrobromide, is different other family. The spectral properties paniculatine interpreted in light
The anti-Trypanosoma cruzi activity of natural products isolated from Azorella compacta was evaluated, with particular emphasis on their effect against intracellular amastigotes. Five diterpenoids A. derived mulinane and azorellane were identified. Only two products, named azorellanol (Y-2) mulin-11,3-dien-20-oic acid (Y-5), showed trypanocidal all stages T. including At 10 µM, these compounds displayed a strong lytic activity. It ranged 88.4 ± 0.6 to 99.0 1 % for strains evaluate, an IC50...
Abstract Aqueous or ethanol infusions of Azorella compacta (llareta) in common with many other plants have been used as antidiabetic the popular medicine altiplanic region Chile. In order to determine if diterpenic compounds chemically elucidated and isolated from this plant are responsible for effect, streptozotocin diabetic rats (507 ± 67 mg/mL glucose) were injected two injections mulinolic acid, azorellanol, mulin‐11,13‐dien‐20‐oic acid at 180 mg/mL. Glycemia animals treated azorellanol...
The structure of paniculatine, an alkaloid L. paniculatum, has been elucidated. It a skeletal different from other alkaloids the Lycopodium family.
The antioxidant properties of Acantholippia deserticola, a herb used in traditional northern Chilean medicine was studied using free radical -generating systems.The 50% aqueous -ethanol extract deserticola protected against non-enzymatic lipid peroxidation microsomal membranes rat, induced by an Fe ++ -ascorbate system and measured spectrophotometrically the TBARS test, had strong scavenging capacities on stable ABTS DPPH radicals.The results shows that IC 50 value -ethanolic A.deserticola...
Transcription factor NF-kappaB plays a key role in the inducible expression of genes mediating proinflammatory effects, and is thus an important target for development antiinflammatory drugs. Laretia acaulis (Cav.) Gill et Hook (Apiaceae) medicinal plant used high Andes mountains different ailments such as diabetes, inflammation general pain. In addition to known azorellanol (2) 7-deacetylazorellanol (4), 13-epiazorellanol (1) was also isolated from aerial part this plant. Its structure...