A5041061779- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Trypanosoma species research and implications
- Medical Malpractice and Liability Issues
- COVID-19 and Mental Health
- Healthcare cost, quality, practices
- Bipolar Disorder and Treatment
- Parasitic Diseases Research and Treatment
- Frailty in Older Adults
- Chemical synthesis and alkaloids
- Bacterial Infections and Vaccines
- Phenothiazines and Benzothiazines Synthesis and Activities
- Healthcare Quality and Management
- Ultrasound in Clinical Applications
- Infections and bacterial resistance
Humanitas University
2024-2025
IRCCS Humanitas Research Hospital
2024-2025
University of Bari Aldo Moro
2019-2024
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients post-surgical infections who had failed previous regimens. A total of 13 were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) classified ill, due severe COVID-19 lung failure; 4/13 (31%) and subjects solid organ transplantation...
Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet clinical need in the intensive care unit (ICU). We aimed to evaluate effectiveness of first-line with old and novel CRAB active antibiotics monomicrobial VAP CRAB. A prospective, observational study was performed mixed non-COVID-19 ICU. The primary outcome measure failure upon targeted therapy. Features independently...
Abstract Background Mental health (MH) is extremely relevant when referring to people living with a chronic disease, such as HIV (PLWH). In fact – although life expectancy and quality have increased since the advent of antiretroviral therapy (ART) PLWH carry high incidence mental disorders, this burden has been exacerbated during COVID-19 pandemic. scenario, UNAIDS set new objectives for 2025, linkage at least 90% people-centered, context-specific MH services. Aim study was determine...
Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality limited treatment. The aim of this study is to compare effectiveness and safety colistin-based versus cefiderocol-based therapies for CRAB-BSI.This a retrospective observational enrolling patients monomicrobial CRAB-BSIs treated colistin or cefiderocol from 1 January 2020, 31 December 2022. 30-day all-cause rate was the primary outcome. A Cox regression analysis...
Abstract Background Pseudomonas aeruginosa bloodstream infections (Pa-BSIs) are still a major cause of mortality in ICUs, posing many treatment uncertainties. Methods This multicentre, retrospective study analysed data from 14 Italian hospitals, including all consecutive adults developing Pa-BSI ICU during 2021–22 and treated with antibiotics for at least 48 h. The primary aim was to identify predictors 30 day using Cox regression. Results were adjusted inverse probability weighting (IPTW)...
The spectrum of COVID-19 clinical manifestations is not yet known. In the elderly, mortality and extrapulmonary involvement appears more frequent than expected.A multicentre-retrospective-case-series study patients, aged ≥65 years, hospitalised between March 1 June 15, 2020. Patients were classified at admission into 3 groups based on their Clinical Frailty Scale (CFS) score: 1-3 (group A), 4-6 B) 7-9 C).Of 206 patients in study, 60 (29%) assigned to group A, B 86 (42%) C. Significantly C or...
Objectives: The aim of this study was to describe our experience a combination treatment including meropenem/vaborbactam (M/V) plus aztreonam (ATM) for bloodstream infections (BSIs) due ceftazidime/avibactam-resistant Klebsiella pneumoniae (CAZ/AVI-R-Kp), which gene typing not available at the time blood culture (BC) results were obtained. Methods: Between 20 July and 22 August 2021, in hospital laboratory, molecular test carbapenemase available. All Gram-negative recorded, characteristics...
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment of SARS-CoV-2 infection and to prevent disease progression. However, some vitro studies have questioned its efficacy on Omicron variants. Therefore, we aim further investigate the real-life settings. (2) Methods: We conducted a retrospective study collecting medical records people with evaluated infectious diseases units Sassari, Foggia, Bari, Italy. included treated who did not receive any 2022. The...
Introduction: Remdesivir (REM) and monoclonal antibodies (mAbs) could alleviate severe COVID-19 in at-risk outpatients. However, data on their use hospitalized patients, particularly elderly or immunocompromised hosts, are lacking. Methods: All consecutive patients with at our unit from 1 July 2021 to 15 March 2022 were retrospectively enrolled. The primary outcome was the progression (P/F < 200). Descriptive statistics, a Cox univariate–multivariate model, an inverse probability...
High rates of lung failure have been reported in haematological patients after SARS-CoV2 infection. An early administration monoclonal antibodies or anti-virals may improve the prognosis. Oral a wider use independently genetic variations virus. Prospective data on malignancies (HMs) are still lacking. Outpatients diagnosed with HM and COVID-19 infection were prospectively treated oral nirmatrelvir/ritonavir molnupiravir. Incidence failure, deaths adverse events was analysed. Long-term...
Optimal β-lactam dosing for the treatment of Gram-negative bacteria bloodstream infections (GNB-BSIs) remains a debated issue. Herein, efficacy and safety loading dose (LD) followed by extended/continuous infusion (EI/CI) versus intermittent bolus (IB) these drugs GNB-BSIs was evaluated.This is retrospective observational study enrolling patients with treated β-lactams from 1 October 2020 to 31 March 2022. The 30 day infection-related mortality rate assessed Cox regression, while risk...
Abstract Objectives To assess the impact of piperacillin/tazobactam MICs on in-hospital 30 day mortality in patients with third-generation cephalosporin-resistant Escherichia coli bloodstream infection treated piperacillin/tazobactam, compared those carbapenems. Methods A multicentre retrospective cohort study was conducted three large academic hospitals Italy between 2018 and 2022. The population comprised monomicrobial E. infection, who received either or carbapenem therapy within 48 h...
The early administration of anti-SARS-CoV-2 monoclonal antibodies (mAb) could decrease the risk severe disease and need inpatients care. Herein, our clinical experience with Bamlanivimab/Etesevimab for treatment SARS-CoV-2 infection through an outpatient service was described. Patients confirmed COVID-19 were selected by General Practitioners (GPs) if eligible to mAb administration, according manufacturer AIFA (Agenzia-Italiana-del-Farmaco) criteria. If suitability Multidisciplinary Team,...
Abstract Background Few data are available regarding the use of direct antiviral agents (DAAs) for chronic hepatitis C in psychiatric patients. The aim study is to assess safety and outcome DAAs patients with comorbidities. Methods This retrospective, observational, single-centre enrolled treated drugs who initiated between 2015 2018. Patients were classified into two groups: A (on anxiolitycs/antidepressant) B antipsychotics). Week-12 sustained virological response (SVR-12) adverse events...
This is a "proof-of-concept" study aiming to evaluate the impact of multistep bundles intervention in management and outcomes patients with gram-negative bloodstream infections (GN-BSIs).This was single-center, quasi-experimental design study. In pre-phase (January 2019 May 2020), were retrospectively enrolled. During post-phase (June 2020 September 2021), all prospectively enrolled nonmandatory 3-step arm including (i) step 1: imaging detect deep foci infection, follow-up blood cultures...
Antimicrobial and diagnostic stewardship (AS/DS) principles are crucial for the management of multidrug-resistant organisms (MDROs) infections. We evaluated impact a pro-active Infectious Disease (ID) consultation on mortality risk patients during an MDROs outbreak in COVID-19 hospital.A quasi-experimental study was performed dedicated hospital, including with suspected/confirmed infection and/or colonization by MDROs, which were managed as follows: (i) according to standard care pre-phase...
Abstract Immune checkpoint inhibitors (ICIs) represent the cornerstone of current treatment non‐small cell lung cancer (NSCLC). However, occurrence concomitant infections might hamper success. All consecutive patients with advanced NSCLC who started ICIs as a first‐ or second‐line therapy from January 1, 2017 to June 30, 2020 were retrospectively evaluated. The infectious events during was correlated clinical characteristics, including previous Cytotoxic Chemotherapy (CC),...
Introduction The aim of this study was to examine the type compensation claims for alleged medical malpractice in field healthcare-related infections Italy. Methods It analyzed which most frequent clinical context, characteristics disputes established, were damages often complained of, possibly censurable behaviors health professionals, and reasons acceptance or rejection request compensation. Results In 90.2%, issue questioned regarded surgical site infections. common pathogens involved...