A5081281097- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Syphilis Diagnosis and Treatment
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Acne and Rosacea Treatments and Effects
- Food Security and Health in Diverse Populations
- Vagus Nerve Stimulation Research
- Sphingolipid Metabolism and Signaling
- Antibiotic Use and Resistance
- Adolescent Sexual and Reproductive Health
- Dermatological and COVID-19 studies
- Respiratory viral infections research
University of Bari Aldo Moro
2019-2024
University of Foggia
2021-2023
Ospedali Riuniti di Foggia
2021
The reason behind the high inter-individual variability in response to SARS-CoV-2 infection and patient’s outcome is poorly understood. present study targets sphingolipid profile of twenty-four healthy controls fifty-nine COVID-19 patients with different disease severity. Sera were analyzed by untargeted targeted mass spectrometry ELISA. Results indicated a progressive increase dihydrosphingosine, dihydroceramides, ceramides, sphingosine, decrease sphingosine-1-phosphate. These changes are...
SARS-CoV-2 transmission mainly occurs through exposure of the upper airway mucosa to infected secretions such as saliva, which are excreted by an person. Thus, oral mucosal immunity plays a central role in prevention and early defense against infection. Although virus-specific antibody response has been extensively investigated blood samples SARS-CoV-2-infected patients vaccinees, local humoral cavity its relationship systemic levels needs be further addressed.
The study aimed to evaluate the impact of dalbavancin therapy on both hospital length-of-stay (LOS) and treatment-related costs, as well describe clinical outcome, in a retrospective cohort patients with diverse Gram-positive bacterial infections, hospitalized different specialty Units. From July 2017 2019, sociodemographic data were collected for all switched treatment infections. LOS costs assessed compared hypothetical scenario where initial standard antimicrobial would have been...
Few data are available regarding the incidence and evolution of neuropsychiatric manifestations in children with a history COVID-19. We herein report five consequent cases pediatric patients psychiatric neurological symptoms long All patients, mainly males, reported asymptomatic-to-mild COVID-19 underwent home self-isolation. Abnormal movements, anxiety, emotional dysregulation were most recurrent observed from few weeks to months after resolution acute infection. A later onset was younger...
Since the outbreak of COVID-19 pandemic, growing attention has been paid to emerging association between severe forms novel coronavirus pneumonia and abnormalities in coagulation parameters, particular elevated D-dimer fibrin degradation product (FDP) levels, that seem relate a poor prognosis are seen as potential predictors acute thrombotic complications including Acute Pulmonary Embolism (APE) (Tang et al., 2020Tang N. Li D. Wang X. al.Abnormal parameters associated with patients...
ObjectivesLimited data are available regarding the occurrence and extent of cardiac rhythm disturbances in patients with COVID-19 treated Remdesivir.MethodsWe present a case series 52 who underwent daily electrocardiogram (ECG) examination after Remdesivir administration.ResultsCompared to baseline, significant heart rate reduction was observed initiation Remdesivir; however, no severe bradycardia or arrhythmias leading clinical complications discontinuation occurred. Heart proportional...
Few data are available about the efficacy, durability, and tolerability of doravirine (DOR) + integrase strand inhibitors (INI) as a switching strategy among antiretroviral therapy (ART)-experienced people living with HIV (PLWH).Retrospective, multicenter cohort study investigating 2 off-label drug associations DOR INI ART-experienced PLWH.The included PLWH who switched to combined either raltegravir (RAL) or dolutegravir (DTG) between June 1, 2020, December 31, 2021, at least 1 follow-up...
The oral mucosa is the first site of SARS-CoV-2 entry and replication, it plays a central role in early defense against infection. Thus, viral load, miRNAs, cytokines, neutralizing activity (NA) were assessed saliva plasma from mild (MD) severe (SD) COVID-19 patients. Here we showed that 84 miRNAs analyzed, 8 differently expressed SD In particular: (1) let-7a-5p, let-7b-5p, let-7c-5p significantly downregulated; (2) miR-23a b miR-29c, as well three immunomodulatory (miR-34a-5p, miR-181d-5p,...
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment of SARS-CoV-2 infection and to prevent disease progression. However, some vitro studies have questioned its efficacy on Omicron variants. Therefore, we aim further investigate the real-life settings. (2) Methods: We conducted a retrospective study collecting medical records people with evaluated infectious diseases units Sassari, Foggia, Bari, Italy. included treated who did not receive any 2022. The...
High School students, recognized as a high-risk group for sexually transmitted infections (STIs), were the focal point of an educational campaign in Southern Italy to share information and good practices about STIs HIV/AIDS. A baseline survey comprising 76 items was conducted via REDCap platform assess students' initial knowledge, attitudes, (KAP) related Sociodemographic variables also investigated. The association between KAP score assessed by Kruskal-Wallis' or Spearman's test,...
Introduction Since the start of SARS-CoV-2 pandemic, several treatment options have been proposed (e.g. steroids, heparin, antivirals and monoclonal antibodies). Remdesivir was first antiviral approved for COVID-19, even though controversial evidence exists concerning efficacy. Therefore, we aimed to conduct a study evaluate whether use remdesivir associated with lower mortality in patients COVID-19.Methods We conducted nested case–control retrospective cohort collecting medical records...
The coronavirus disease 2019 (COVID-19) pandemic has affected hundreds of millions individuals and caused deaths worldwide. Predicting the clinical course is pivotal importance to manage patients. Several studies have found hematochemical alterations in COVID-19 patients, such as inflammatory markers. We retrospectively analyzed anamnestic data laboratory parameters 303 patients diagnosed with who were admitted Polyclinic Hospital Bari during first phase global pandemic. After pre-processing...
Background: Limited evidence is available about sleep quality changes associated with the use of Cabotegravir (CAB), a new, long-acting (LA) antiretroviral (ARV) drug belonging to class Integrase Strand Transfer Inhibitors (INSTIs). Methods: Pittsburgh Sleep Quality Index (PSQI) was calculated in 53 people living HIV (PLWH) under care outpatient services two Italian Infectious Diseases Centers Apuliabefore (M0) and seven months after (M7) switch LA CAB. Global scores relative subitems were...
Approximately 500,000 migrants work in the agricultural sector Italy. Many of them live shantytowns, wrongly called "ghettos", far away from city centers, with no water, proper hygienic conditions or health services. The aim this study is to assess general and HIV prevalence by giving sanitary sustenance.Between June 2019 February 2020, we performed a screening campaign for HIV-diabetes-hypertension, involving living three Apulian establishments: ghetto Pista, "Sankara House" "Arena...
Background: The increased vascular risk associated with varicella–zoster virus (VZV) reactivation is extensively established in the general population. This retrospective cohort study investigates whether this observation holds for People Living HIV (PLWH), a group already confronting heightened cardiovascular risk. Methods: Among PLWH who initiated antiretroviral therapy (ART) at our center and have been under care >24 months since 1st January 2005, individuals history of herpes zoster...
Despite the availability of vaccines and antivirals biological evolution SARS-CoV-2, rate hospitalizations deaths from COVID-19 remains high in Italy. It is crucial to understand whether how clinical characteristics patients hospitalized for have changed over 2021–2022 which risk factors are currently associated with adverse outcomes develop targeted interventions. In this study, we present compare 310 who were between 1 August 9 December 2021, when Delta SARS-CoV-2 variant was prevalent...
The aim of this study is to describe the features, outcomes, and clinical issues related Remdesivir administration a cohort 220 patients (pts) with COVID-19 hospitalized throughout last two pandemic waves in Italy. One hundred nine pts were enrolled from 1 September 2020, 28 February 2021 (Group A) 111 March 30 B). Notably, no differences reported between groups neither timing hospitalization. nor symptoms onset. Remarkably, higher proportion severe was observed Group B (25% vs. 10%, p <...
Data on the long-term durability of rilpivirine (RPV) are still scarce. A two-center retrospective study was performed, including all people living with HIV (PLWH) treated tenofovir disoproxil fumarate/emtricitabine (TDF/FTC)/RPV or alafenamide (TAF)/FTC/RPV in period January 2013–December 2019. Aims were to assess rate discontinuation RPV single-tablet regimen (STR) and identify factors associated risk according Cox's regression analysis. total 684 PLWH enrolled. Mean duration RPV-STR...
This survey aimed to understand how far the Italian infectious diseases (ID) specialists are confident in "Undetectable = Untransmittable" (U U) message and translate this concept into clinical practice. An anonymous was distributed by e-mail 286 clinicians collect their opinions regarding six situations potentially at risk of HIV transmission between virologically suppressed patients seronegative individuals who possibly require postexposure prophylaxis (PEP). Overall, 51% ID deemed zero...
Objectives: Heavily Treatment-Experienced (HTE) People Living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed investigate the prevalence and features of HTE individuals followed up inthe ICONA cohort as December 31, 2021.Methods: were defined based on meeting specific conditions concerning their current ART history 2021.Descriptive statistics performed by status. Regression analyses explored factors associated becoming pre-ART...