A5005109979- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Intracranial Aneurysms: Treatment and Complications
- Sarcoma Diagnosis and Treatment
- Neurological disorders and treatments
- Spinal Dysraphism and Malformations
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Cardiac, Anesthesia and Surgical Outcomes
- CNS Lymphoma Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Retinal and Optic Conditions
- Pediatric Pain Management Techniques
- ATP Synthase and ATPases Research
- Lymphoma Diagnosis and Treatment
- Congenital gastrointestinal and neural anomalies
- Bone Tumor Diagnosis and Treatments
- Neuroblastoma Research and Treatments
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
University of Bari Aldo Moro
2019-2024
Bambino Gesù Children's Hospital
2015-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2018
Boston Children's Hospital
2014
OBJECTIVE During the last 3 decades, robotic technology has rapidly spread across several surgical fields due to continuous evolution of its versatility, stability, dexterity, and haptic properties. Neurosurgery pioneered development robotics, with aim improving quality procedures requiring a high degree accuracy safety. Moreover, robot-guided approaches are special interest in pediatric patients, who often have altered anatomy challenging relationships between diseased eloquent structures....
Purpose: To evaluate factors influencing clinical and radiological outcome of extended endoscopic endonasal transtuberculum/transplanum approach (EEA-TTP) for giant pituitary adenomas (GPAs). Methods: We recruited prospectively all consecutive GPAs patients undergoing EEA-TTP between 2015 2019 in 5 neurosurgical centers. Preoperative radiologic features, visual hormonal outcomes, extent resection (EoR), complications recurrence rates were recorded analyzed. Results: Of 1169 treated adenoma,...
The study aimed to evaluate the impact of dalbavancin therapy on both hospital length-of-stay (LOS) and treatment-related costs, as well describe clinical outcome, in a retrospective cohort patients with diverse Gram-positive bacterial infections, hospitalized different specialty Units. From July 2017 2019, sociodemographic data were collected for all switched treatment infections. LOS costs assessed compared hypothetical scenario where initial standard antimicrobial would have been...
Glioblastoma multiforme (GBM) is characterized by a remarkable cellular and molecular heterogeneity that make the behavior of this tumor highly variable resistant to therapy. In addition, most serious clinical complication GBM other brain tumors development vasogenic edema which dramatically increase intracranial pressure. present study we evaluate expression, supramolecular organization spatial distribution AQP4 AQP4ex, new readthrough isoform AQP4, in relationship with degree progression....
Kabuki syndrome is a rare disorder characterized by the association of mental retardation and postnatal growth deficiency with distinctive facial appearance, skeletal anomalies, cardiac renal malformation. Two causative genes have been identified in patients syndrome. Mutation KMT2D (MLL2) was 55–80 % patients, while 9–14 negative mutation KDM6A gene. So far, few tumors reported We describe first case patient spinal ependymoma A 23 years old girl followed at our Center for mutated since she...
AQP4ex is a recently discovered isoform of AQP4 generated by translational readthrough mechanism. It strongly expressed at the astrocyte perivascular endfeet as component supramolecular membrane complex, commonly called orthogonal array particles (OAP), together with canonical isoforms M1 and M23 AQP4. Previous site-directed mutagenesis experiments suggested potential role serine331 serine335, located in extended peptide AQP4ex, water channel activity phosphorylation. In present study we...
Background: Vestibular Schwannomas are benign tumors arising from the VIII CN. Surgical treatment is indicated in case of larger than 2.5 cm cerebellopontine angle or cranial nerve dysfunction. The aim present study was to evaluate QoL by means PANQOL questionnaire a group surgically treated patients mainly affected large and giant VS Methods: All underwent preoperative postoperative otoneurological evaluation gadolinium enhanced MRI they completed, independently, at last follow up. Results:...
Purpose Mesenchymal chondrosarcoma (MCS) is an aggressive variant of and a rare tumor, particularly within the pediatric population. Commonly, MCS originates in bone, but it can also arise extraskeletal sites, such as brain intraspinal area. Due to rarity this there are no guidelines for its optimal treatment. Methods We report case intradural extra medullary MCS, located at T11–T12 level, 14-year-old male. The tumor was documented by magnetic resonance imaging treated with gross total...
The aim of this paper was to identify and characterize all the segmental radiculomedullary arteries (RMAs) that supply thoracic lumbar spinal cord.
Abstract Mesenchymal tumors of the central nervous system (CNS) include numerous entities, with different pathological features and biological behavior. non-meningothelial are rare comprise neoplasms that exclusive to CNS or show peculiar when occurring in compared other sites. Within this group there three new classified on basis specific molecular alterations included 5th edition WHO Classification Tumors: primary intracranial sarcoma; DICER1-mutant; CIC-rearranged mesenchymal tumor,...
Aquaporin-4 (AQP4) and its extended isoform, AQP4ex, are crucial for regulating brain water homeostasis. Mis-localization of these isoforms is implicated in various tumors, including glioblastoma multiforme (GBM). This study explores AQP4 isoform expression localization Pilocytic Astrocytomas (PA), a circumscribed astrocytic low-grade glioma, compared to GBM, an adult-type diffuse high grade glioma. We found significant upregulation AQP4ex PA, with notable mis-localization deviating from the...