A5082578432- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Tea Polyphenols and Effects
- HIV/AIDS Research and Interventions
- Artificial Intelligence in Healthcare and Education
- Bacillus and Francisella bacterial research
- Identification and Quantification in Food
- Microfluidic and Capillary Electrophoresis Applications
- COVID-19 and healthcare impacts
- Respiratory viral infections research
- Sex and Gender in Healthcare
- Clinical Reasoning and Diagnostic Skills
- Machine Learning in Healthcare
- Autophagy in Disease and Therapy
- Vibrio bacteria research studies
- HIV, Drug Use, Sexual Risk
- Electrochemical sensors and biosensors
- Protein Hydrolysis and Bioactive Peptides
- Phytochemicals and Antioxidant Activities
- Tannin, Tannase and Anticancer Activities
- Anesthesia and Sedative Agents
- HIV Research and Treatment
University of Sassari
2003-2024
Human umbilical endothelial cells (HUVECs) are widely used to study the physiology and pathology that might be involved in sex gender differences detected at cardiovascular level. This evaluated whether HUVECs sexually dimorphic their morphological, proliferative migratory properties gene protein expression of oestrogen androgen receptors nitric oxide synthase 3 (NOS3). Moreover, because autophagy is influenced by sex, its degree was analysed male female (MHUVECs FHUVECs).Umbilical cords...
Abstract Objectives Advancements in Artificial Intelligence(AI) have made platforms like ChatGPT increasingly relevant medicine. This study assesses ChatGPT’s utility addressing bacterial infection-related questions and antibiogram-based clinical cases. Methods involved a collaborative effort involving infectious disease (ID) specialists residents. A group of experts formulated six true/false, open-ended questions, cases with antibiograms for four types infections (endocarditis, pneumonia,...
Background: Prevention campaigns have led to a significant decrease in new HIV diagnoses Western Europe, while other sexual transmitted infections (STIs) shown an opposite trend. Several educational programs are promoted among young students, whereas informational addressing the general population scarce. We aimed investigate level of awareness regarding STIs population. Methods: proposed questionnaire and Italy. assigned 1 point correct, 0.5 partially 0 wrong answers. collected data about...
Abstract Since the start of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) pandemic, several treatments have been proposed to cure coronavirus disease 2019 (COVID‐19) and prevent it. Molnupiravir is a ribonucleoside prodrug N ‐hydroxycytidine with an in vitro vivo activity against SARS‐CoV‐2. We conducted retrospective cohort study that included all people treated molnupiravir between January 10, 2022, March 31, at University Hospital Sassari. was prescribed, according Italian...
Since the start of SARS-CoV-2 pandemic, several treatments have been proposed to prevent progression disease. Currently, three antiviral (molnupiravir, nirmaltrevir/r, remdesivir) and two monoclonal antibodies (casirivimab/imdevimab sotrovimab) are available in Italy. Therefore, we aimed evaluate presence risk factors associated with disease progression. We conducted a retrospective cohort study, including all patients confirmed diagnosis evaluated between 01/01/2022 ad 10/05/2022 by our...
Since the start of SARS-CoV-2 pandemic, several scores have been proposed to identify infected individuals at a higher risk progression and death. The most famous is 4C score. However, it was developed in early 2020. Our study aimed evaluate accuracy score during wave which Omicron variant prevalent. An observational conducted an Italian University Hospital between 1 January 31 July 2022. A receiver operating characteristic (ROC) curve analysis performed ability predict mortality. Overall,...
We aimed to evaluate the prevalence and characteristics of people living with HIV (PLWH) eligible for long-acting injectable (LAI) regimen cabotegravir (CAB) rilpivirine (RPV), in comparison ineligible individuals.This was an observational, cross-sectional study from ARCA cohort, including virologically suppressed PLWH at least one genotypic resistance testing (GRT) reverse transcriptase integrase plasma and/or PBMCs. Eligibility criteria LAI CAB+RPV were: negative HBsAg, absence previous...
Introduction Since the start of SARS-CoV-2 pandemic, several treatment options have been proposed (e.g. steroids, heparin, antivirals and monoclonal antibodies). Remdesivir was first antiviral approved for COVID-19, even though controversial evidence exists concerning efficacy. Therefore, we aimed to conduct a study evaluate whether use remdesivir associated with lower mortality in patients COVID-19.Methods We conducted nested case–control retrospective cohort collecting medical records...
Abstract Background Several scores aimed at predicting COVID-19 progression have been proposed. As the variables vaccination and early SARS-CoV-2 treatment were systematically excluded from prognostic scores, present study's objective was to develop a new model adapted current epidemiological scenario. Methods We included all patients evaluated by Infectious Disease Unit in Sassari, with infection without signs of respiratory failure first evaluation (P/F > 300). defined prescription...
Hospital-acquired pneumonia (HAP) and ventilation-associated (VAP) are challenging clinical conditions due to the tissue penetrability of lung. This study aims evaluate potential role fosfomycin (FOS) associated with ceftazidime/avibactam (CZA) in improving outcome this setting. We performed a retrospective including people HAP or VAP treated CZA CZA+FOS for at least 72 h. Clinical data were collected from SUSANA study, multicentric cohort monitor efficacy safety newer antimicrobial agents....
The use of amperometric biosensors has attracted particular attention in recent years, both from researchers and companies, as they have proven to be low-cost, reliable, very sensitive devices, with a wide range uses different matrices. continuous development biosensors, since their involves an enzyme, is specifically aimed at keeping increasing the catalytic properties loaded protein, so able same device over time. present study investigate impact glycerol polysaccharides, presence...
Sex has largely been neglected in cellular studies. Autophagy is a sophisticatedly reg- ulated homeostatic mechanism, which ensures cell’s constituent turnover. Under physiological conditions, autophagy levels are usually low (constitutive autophagy), but can be induced by numerous stresses such as starvation. The influence of sex on studied either vitro or vivo, and previous our findings demonstrated the existence differences rat heart HUVECs. Vascular smooth muscle cells (VSMCs) good...
Reactive oxygen species (ROS) cause cell damages through protein oxidation leading to pathological processes like cardiovascular disease neurological degeneration and cancer (1). Antioxidants molecules, due their ability scavenge neutralize free radicals, might play a pivotal role in the prevention of these disease. Interestingly, besides neutralizing ROS, it’s now proved that some promising antioxidant including green tea polyphenols (2), induce expression genes involved cellular protection...