A5053423077- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Diabetes and associated disorders
- Vibrio bacteria research studies
- Vitamin D Research Studies
- Virus-based gene therapy research
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Bacteriophages and microbial interactions
- Viral Infections and Immunology Research
University of Rome Tor Vergata
2021-2025
Azienda Sanitaria Locale CN2
2019
The process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic diversification is still ongoing and has very recently led to the emergence a new variant concern (VOC), defined as Omicron or B.1.1.529. VOC most divergent identified so far generated immediate for its potential capability increase SARS-CoV-2 transmissibility and, more worryingly, escape therapeutic vaccine-induced antibodies. Nevertheless, clear definition mutational spectrum missing. Herein, we provide...
Specific HBsAg mutations are known to hamper recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape from 2005 2019 correlation with virological parameters in a large cohort patients infected HBV genotype-D (N = 947), dominant Europe. Overall, 17.7% harbours ≥1 mutation highest prevalence subgenotype-D3. Notably, complex profiles...
ABSTRACT Background and Aims HDV exploits HBV surface‐protein (HBsAg) for entering into hepatocytes. HBsAg consists of 3 isoforms: Large‐ (L‐HBs, predominantly present in virions mediating binding to NTCP‐receptor), Middle‐ (M‐HBs) Small‐HBsAg (S‐HBs). Here, we investigated the kinetics HBs isoforms under bulevirtide treatment (BLV). Methods 67 consecutive patients with HDV‐related compensated cirrhosis starting BLV 2 mg/day were enrolled. L‐HBs, M‐HBs S‐HBs quantified by ad‐hoc ELISAs...
We aimed to evaluate the prevalence and characteristics of people living with HIV (PLWH) eligible for long-acting injectable (LAI) regimen cabotegravir (CAB) rilpivirine (RPV), in comparison ineligible individuals.This was an observational, cross-sectional study from ARCA cohort, including virologically suppressed PLWH at least one genotypic resistance testing (GRT) reverse transcriptase integrase plasma and/or PBMCs. Eligibility criteria LAI CAB+RPV were: negative HBsAg, absence previous...
The performance of diagnostic polymerase chain reaction (PCR) assays can be impacted by SARS-CoV-2 variability as this is dependent on the full complementarity between PCR primers/probes and viral target templates. Here, we investigate genetic regions recognized utilized based nucleotide mismatching analysis. We evaluated variation in binding 73 targeting Nucleocapsid (N, N = 36), Spike (S, 22), RNA-dependent RNA-polymerase/Helicase (RdRp/Hel, 15) publicly available PCR-based assays. Over...
In this study, we provided a retrospective overview in order to better define SARS-CoV-2 variants circulating Italy during the first two years of pandemic, by characterizing spike mutational profiles and their association with viral load (expressed as ct values), N-glycosylation pattern, hospitalization vaccination. Next-generation sequencing (NGS) data were obtained from 607 individuals (among them, 298 vaccinated and/or 199 hospitalized). Different rates observed over time among concern...
Here we investigate Hepatitis D virus (HDV)-prevalence in Italy and its fluctuations over time provide an extensive characterization of HDV-infected patients.The rate HDV seroprevalence chronicity was assessed 1579 hepatitis B surface antigen (HBsAg)+ patients collected from 2005 to 2022 Central Italy.In total, 45.3% HBsAg+ received screening with increasing temporal trend: 15.6% (2005-2010), 45.0% (2011-2014), 49.4% (2015-2018), 71.8% (2019-2022). By multivariable model, factors correlated...
HBV and HIV coinfection is a common occurrence globally, with significant morbidity mortality. Both viruses lead to immune dysregulation including changes in natural killer (NK) cells, key component of antiviral defense promising target for cure strategies. Here we used high-throughput single-cell analysis explore the cell landscape people mono-infection HIV/HBV coinfection, on therapy, emphasis identifying distinctive characteristics NK subsets that can be therapeutically harnessed.
We aimed to study hepatitis D virus (HDV) prevalence and risk of progression severe liver-related events (SLRE) in HBsAg positive people living with HIV (PLWH) Italy; role HDV-RNA copy levels, HCV coinfection nadir CD4 counts were also investigated.
Vitamin D3 reported in Italy 2017 the net expenditure of almost €180 million, reaching first place for consumption and third conventional pharmaceutical spending. The aim study was to evaluate whether a shift vitamin prescriptions toward 100 000 IU formulation, less costly, could allow savings from health-care perspective. An approach promoting prescription this formulation has been applied local health authority (ASL CN2) Piedmont Region (Italy) starting 2015. retail market analyzed year...