A5032978217- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- Infections and bacterial resistance
- COVID-19 and Mental Health
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Poxvirus research and outbreaks
- Intensive Care Unit Cognitive Disorders
- Infective Endocarditis Diagnosis and Management
- Reconstructive Surgery and Microvascular Techniques
- Trypanosoma species research and implications
- Breast Implant and Reconstruction
- Pneumocystis jirovecii pneumonia detection and treatment
- Healthcare cost, quality, practices
- Vaccine Coverage and Hesitancy
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
University of Bari Aldo Moro
2020-2024
Humanitas University
2024
IRCCS Humanitas Research Hospital
2024
University of Perugia
2018-2021
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients post-surgical infections who had failed previous regimens. A total of 13 were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) classified ill, due severe COVID-19 lung failure; 4/13 (31%) and subjects solid organ transplantation...
Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet clinical need in the intensive care unit (ICU). We aimed to evaluate effectiveness of first-line with old and novel CRAB active antibiotics monomicrobial VAP CRAB. A prospective, observational study was performed mixed non-COVID-19 ICU. The primary outcome measure failure upon targeted therapy. Features independently...
Abstract Background Mental health (MH) is extremely relevant when referring to people living with a chronic disease, such as HIV (PLWH). In fact – although life expectancy and quality have increased since the advent of antiretroviral therapy (ART) PLWH carry high incidence mental disorders, this burden has been exacerbated during COVID-19 pandemic. scenario, UNAIDS set new objectives for 2025, linkage at least 90% people-centered, context-specific MH services. Aim study was determine...
Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality limited treatment. The aim of this study is to compare effectiveness and safety colistin-based versus cefiderocol-based therapies for CRAB-BSI.This a retrospective observational enrolling patients monomicrobial CRAB-BSIs treated colistin or cefiderocol from 1 January 2020, 31 December 2022. 30-day all-cause rate was the primary outcome. A Cox regression analysis...
Objectives: The aim of this study was to describe our experience a combination treatment including meropenem/vaborbactam (M/V) plus aztreonam (ATM) for bloodstream infections (BSIs) due ceftazidime/avibactam-resistant Klebsiella pneumoniae (CAZ/AVI-R-Kp), which gene typing not available at the time blood culture (BC) results were obtained. Methods: Between 20 July and 22 August 2021, in hospital laboratory, molecular test carbapenemase available. All Gram-negative recorded, characteristics...
Since the outbreak of COVID-19 pandemic, growing attention has been paid to emerging association between severe forms novel coronavirus pneumonia and abnormalities in coagulation parameters, particular elevated D-dimer fibrin degradation product (FDP) levels, that seem relate a poor prognosis are seen as potential predictors acute thrombotic complications including Acute Pulmonary Embolism (APE) (Tang et al., 2020Tang N. Li D. Wang X. al.Abnormal parameters associated with patients...
(1) Introduction: Since May 2021, sotrovimab has been available in Italy for early treatment of SARS-CoV-2 infection and to prevent disease progression. However, some vitro studies have questioned its efficacy on Omicron variants. Therefore, we aim further investigate the real-life settings. (2) Methods: We conducted a retrospective study collecting medical records people with evaluated infectious diseases units Sassari, Foggia, Bari, Italy. included treated who did not receive any 2022. The...
Introduction: Remdesivir (REM) and monoclonal antibodies (mAbs) could alleviate severe COVID-19 in at-risk outpatients. However, data on their use hospitalized patients, particularly elderly or immunocompromised hosts, are lacking. Methods: All consecutive patients with at our unit from 1 July 2021 to 15 March 2022 were retrospectively enrolled. The primary outcome was the progression (P/F < 200). Descriptive statistics, a Cox univariate–multivariate model, an inverse probability...
Optimal β-lactam dosing for the treatment of Gram-negative bacteria bloodstream infections (GNB-BSIs) remains a debated issue. Herein, efficacy and safety loading dose (LD) followed by extended/continuous infusion (EI/CI) versus intermittent bolus (IB) these drugs GNB-BSIs was evaluated.This is retrospective observational study enrolling patients with treated β-lactams from 1 October 2020 to 31 March 2022. The 30 day infection-related mortality rate assessed Cox regression, while risk...
Abstract Objectives To assess the impact of piperacillin/tazobactam MICs on in-hospital 30 day mortality in patients with third-generation cephalosporin-resistant Escherichia coli bloodstream infection treated piperacillin/tazobactam, compared those carbapenems. Methods A multicentre retrospective cohort study was conducted three large academic hospitals Italy between 2018 and 2022. The population comprised monomicrobial E. infection, who received either or carbapenem therapy within 48 h...
High School students, recognized as a high-risk group for sexually transmitted infections (STIs), were the focal point of an educational campaign in Southern Italy to share information and good practices about STIs HIV/AIDS. A baseline survey comprising 76 items was conducted via REDCap platform assess students' initial knowledge, attitudes, (KAP) related Sociodemographic variables also investigated. The association between KAP score assessed by Kruskal-Wallis' or Spearman's test,...
Immunocompromised patients show an impaired vaccine response and remain at high risk of severe COVID-19, despite vaccination. Neutralizing monoclonal antibodies against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed for prophylaxis treatment. The combination tixagevimab/cilgavimab (AZD7442) has authorized emergency use as pre-exposure but data on safety efficacy in kidney transplant recipients during the Omicron period are limited.
Since May 2022, the monkeypox (MPX) virus has represented an emerging issue due to outbreaks in non-endemic areas. This report presents first case of paraphimosis caused by MPX infection during outbreak. The patient accessed emergency department for a sudden onset swelling penis and lesions that brought about stenosis foreskin. He therefore underwent dorsal slit procedure with resolution. No antiviral therapy was required. A multidisciplinary approach should be preferred management MPX,...
This is a "proof-of-concept" study aiming to evaluate the impact of multistep bundles intervention in management and outcomes patients with gram-negative bloodstream infections (GN-BSIs).This was single-center, quasi-experimental design study. In pre-phase (January 2019 May 2020), were retrospectively enrolled. During post-phase (June 2020 September 2021), all prospectively enrolled nonmandatory 3-step arm including (i) step 1: imaging detect deep foci infection, follow-up blood cultures...
Antimicrobial and diagnostic stewardship (AS/DS) principles are crucial for the management of multidrug-resistant organisms (MDROs) infections. We evaluated impact a pro-active Infectious Disease (ID) consultation on mortality risk patients during an MDROs outbreak in COVID-19 hospital.A quasi-experimental study was performed dedicated hospital, including with suspected/confirmed infection and/or colonization by MDROs, which were managed as follows: (i) according to standard care pre-phase...
Abstract Immune checkpoint inhibitors (ICIs) represent the cornerstone of current treatment non‐small cell lung cancer (NSCLC). However, occurrence concomitant infections might hamper success. All consecutive patients with advanced NSCLC who started ICIs as a first‐ or second‐line therapy from January 1, 2017 to June 30, 2020 were retrospectively evaluated. The infectious events during was correlated clinical characteristics, including previous Cytotoxic Chemotherapy (CC),...
The rapid and accurate identification of pathogens responsible for sepsis is essential prompt effective antimicrobial therapy. Molecular technologies have been developed to detect the most common causative agents, with high sensitivity short time result (TTR). T2 Bacteria Panel (T2), based on a combination PCR magnetic resonance, can identify directly in blood samples Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecium, Acinetobacter...