A5071851610- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Complement system in diseases
- Long-Term Effects of COVID-19
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- COVID-19 and healthcare impacts
- Hepatitis C virus research
- Animal Virus Infections Studies
- COVID-19 Impact on Reproduction
University of Bari Aldo Moro
2020-2024
Immunocompromised patients show an impaired vaccine response and remain at high risk of severe COVID-19, despite vaccination. Neutralizing monoclonal antibodies against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed for prophylaxis treatment. The combination tixagevimab/cilgavimab (AZD7442) has authorized emergency use as pre-exposure but data on safety efficacy in kidney transplant recipients during the Omicron period are limited.
Background: Solid-organ transplant (SOT) recipients are at a high risk of severe COVID-19, and priority for vaccination. Here, we describe three cases COVID-19 caused by SARS-CoV-2 B.1.1.7 lineage in vaccinated SOT recipients. Methods: Three patients were hospitalized the Policlinico Hospital Bari (southern Italy) underwent nasopharyngeal swabs molecular detection genes spike protein mutations real-time PCR. One sample was subjected to whole-genome sequencing. Results: patient heart...
COVID-19 in kidney transplant recipients is associated with high morbidity and mortality. In this study we aimed to evaluate: (i) the seroconversion rate after BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine, (ii) factors humoral response, (iii) clinical outcome of transplanted patients.We enrolled a cohort 743 followed up from March 2020 until April 2022. A subset 336 patients, who received three-doses was analyzed terms kinetics immune response compared control group 94 healthcare workers....
Endotheliosis, thrombotic microangiopathy and complement system over activation have been described as pathologic features of tissue damage in the setting coronavirus disease. Interestingly, complement-mediated cell injury is also a typical feature atypical Hemolytic Uremic Syndrome. Indeed, growing body literature has higher risk recurrence, aHUS patients who test positive for SARS-CoV-2. The correct clinical therapeutic management with history HUS SARS-CoV-2 infection not well established....
Abstract BACKGROUND AND AIMS SARS-CoV-2 pandemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients, such as nephropathic are still scarce. Patients with chronic kidney disease (CKD) and on haemodialysis (HD) at risk a more severe course worst outcomes. Here, we aimed to describe the characteristics CKD HD patients infection, admitted Covid Nephrology Unit first three waves, analysing mortality rate factors for this subgroup patients. METHOD A was...
Abstract BACKGROUND AND AIMS COVID-19 infection in solid organ transplant recipients (SOT) is associated with increased morbidity and mortality due to comorbidities immunosuppression state (Chaudhry ZS et al, 2020). Although vaccines represent the greatest hope control pandemic, several studies showed low immunogenicity of a two-dose mRNA vaccine regimen SOT as compared general population (Boyarsky BJ 2021). Based on this evidence, September 2021, Italian Medicine Agency (AIFA) authorized...