A5043634620- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Tuberculosis Research and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Legionella and Acanthamoeba research
- Genital Health and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Cervical Cancer and HPV Research
- Diagnosis and treatment of tuberculosis
- COVID-19 and healthcare impacts
- Infectious Aortic and Vascular Conditions
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive tract infections research
- Genomics and Phylogenetic Studies
- Syphilis Diagnosis and Treatment
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2023-2025
University of Bari Aldo Moro
2020-2024
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients post-surgical infections who had failed previous regimens. A total of 13 were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) classified ill, due severe COVID-19 lung failure; 4/13 (31%) and subjects solid organ transplantation...
Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet clinical need in the intensive care unit (ICU). We aimed to evaluate effectiveness of first-line with old and novel CRAB active antibiotics monomicrobial VAP CRAB. A prospective, observational study was performed mixed non-COVID-19 ICU. The primary outcome measure failure upon targeted therapy. Features independently...
Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality limited treatment. The aim of this study is to compare effectiveness and safety colistin-based versus cefiderocol-based therapies for CRAB-BSI.This a retrospective observational enrolling patients monomicrobial CRAB-BSIs treated colistin or cefiderocol from 1 January 2020, 31 December 2022. 30-day all-cause rate was the primary outcome. A Cox regression analysis...
Abstract Background Bone infections such as chronic fungal erosive osteomyelitis are uncommon forms of bone infection. The endemic dimorphic fungus Coccidioides impact generally immunocompromised patients. These frequently have no symptoms and the clinical signs remain undetected, allowing infection to worsen over weeks or months. Mycotic arthritis is one rarest symptoms; it hard distinguish from other types arthritis, which slows down diagnosis procedure. Case presentation In order...
Probiotic administration has become common practice in neonatal intensive care units (NICUs) to prevent necrotizing enterocolitis (NEC) and promote gut health preterm infants. While probiotics are generally considered safe, rare cases of probiotic-related sepsis have been reported. We present a case Lactobacillus rhamnosus infant, highlighting the challenges involved its diagnosis. The infant developed symptoms on 13th day probiotic treatment. Laboratory analyses, including MALDI-TOF,...
This study describes two cases of bacteraemia sustained by a new putative Pannonibacter species isolated at the U.O.C. Microbiology and Virology Policlinico Bari (Bari, Italy) from blood cultures patients admitted to Paediatric Oncohaematology Unit. spp. is an environmental Gram-negative bacterium not commonly associated with nosocomial infections. Species identification was performed using Sanger sequencing 16S rRNA gene Whole-Genome Sequencing (WGS) for both strains. Genomic analyses...
Aspergillosis is a disease caused by Aspergillus, and invasive pulmonary aspergillosis (IPA) the most common fungal infection leading to death in severely immuno-compromised patients. The literature reports Aspergillus co-infections patients with COVID-19 (CAPA). Diagnosing CAPA clinically complex since symptoms are non-specific, performing bronchoscopy difficult. Generally, microbiological diagnosis of based on cultural methods searching for circulating antigens galactomannan 1,3-β-D-glucan...
Aim: Infections by Klebsiella pneumoniae carbapenemase (KPC)-producing K. represent a major challenge because of limited treatment strategies. New β-lactam/β-lactamase inhibitor associations may help to deal with this challenge. The aim study is evaluate the in vitro susceptibility KPC-producing for meropenem/vaborbactam comparison ceftazidime/avibactam against. Materials and methods: Twenty-eight strains isolated from blood cultures were evaluated. Testing was performed E-test gradient...
The COVID-19 pandemic has undone years of progress in providing essential TB services and controlling the burden. Italy, a low burden country, an incidence 7.1 cases per 100,000 people. To control spreading Italy is critical to investigate characteristics patients with worst outcomes highest risk adverse events related antituberculosis therapy. Therefore, we conducted large retrospective study admitted Clinic Infectious Diseases University Bari, order describe clinical presentation factors...
Human papillomavirus (HPV) is considered the commonest viral cause of sexually transmitted infections. The impact social distance measures due to Covid-19 pandemic on HPV spread unknown. Therefore, this study has analyzed seven-year trend prevalence in all patients tested for DNA at Microbiology and Virology Unit Bari Policlinico. Moreover, 2020 been compared with previous year ones order evaluate consequences lockdown distancing transmission risks. From 2013 2020, we retrospectively 64 anal...
Serratia marcescens (SM) is a Gram-negative bacterium that frequently found in the environment. Since 1913, when its pathogenicity was first demonstrated, number of infections caused by SM has increased. There ample evidence causes nosocomial immunocompromised or critically ill patients admitted to intensive care units (ICUs), but also newborns neonatal ICUs (NICUs). In this study, we evaluated possible genetic correlation PFGE between clinical and environmental strains from NICU ICU...
AbstractDuring the Sars-Cov-2 pandemic, Stenotrophomonas maltophilia (S.maltophilia) secondary pulmonary infections have increased, especially in critically ill patients, highlighting need for new therapeutic options. Trimethoprim-sulfamethoxazole (SXT) is treatment of choice but increase resistant strains or adverse drug reactions limited its clinical use. Recently ceftazidime/avibactam (CZA) has been approved multi (MDR) Gram-negative bacteria infections, including hospital acquired...
is an emerging yeast considered a serious threat to global health. We report the first case of
Since December 2019, the Coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has spread from China, becoming a pandemic. Bacterial and fungal co-infections may lead to increase in COVID-19 severity with decrease patients survive. The aim of this work was evaluate bacterial admitted ICU comparison recovered pre-COVID-19 era order understand whether pandemic had changed incidence overinfections ICU. In fact, epidemiological data should guide choice...
Meropenem/vaborbactam (M/V) is a new carbapenem-carbapenemase inhibitor combination drug active against extensively resistant Gram-negative pathogens. Studies about its efficacy and place in therapy are limited "real-life" no data available for deep site infections, like vascular graft infections. We present case of patient successfully treated with M/V thoracic aorta infection, placed traumatic penetrating aortic ulcer, due to an KPC-producing Klebsiella pneumoniae ceftazidime/ avibactam....
Legionnaires' disease is a severe form of pneumonia caused by the inhalation or aspiration water droplets contaminated with Legionella pneumophila and other species. These bacteria are commonly found in natural habitats man-made systems. significant public health problem, especially healthcare settings where patients may be exposed to environmental sources. Nosocomial outbreaks have been reported worldwide, leading high morbidity mortality rates, increased costs. This study aimed compare,...
Recently, vancomycin-resistant strains have emerged as a significant threat to patients. This study describes the local epidemiological trend of E. faecium (VR-E. faecium) isolated from urine, their antibiotic susceptibility empirical treatment, patients and wards at increased risk. We retrospectively analyzed isolates collected January 2013 December 2020 part standard patient care University Hospital Bari, Italy. The antimicrobi