A5064301127- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Legionella and Acanthamoeba research
- Viral gastroenteritis research and epidemiology
- Dental Research and COVID-19
- Fecal contamination and water quality
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Systemic Lupus Erythematosus Research
- Pneumonia and Respiratory Infections
- Infection Control and Ventilation
- Antifungal resistance and susceptibility
- Helicobacter pylori-related gastroenterology studies
- Dental Trauma and Treatments
- Galectins and Cancer Biology
- Groundwater and Isotope Geochemistry
- Infection Control in Healthcare
- Urban Planning and Valuation
- Medical Device Sterilization and Disinfection
- Engine and Fuel Emissions
- COVID-19 Digital Contact Tracing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Infections and Treatments
- Neonatal and Maternal Infections
- Systemic Sclerosis and Related Diseases
University of Bari Aldo Moro
2014-2024
We evaluated the epidemiology of Candida bloodstream infections in neonatal intensive care unit (NICU) an Italian university hospital during a 9-year period as means quantifying burden infection and identifying emerging trends. Clinical data were searched for microbiological laboratory database. For comparative purposes, we performed review NICU candidemia. Forty-one candidemia cases reviewed (overall incidence, 3.0 per 100 admissions). parapsilosis sensu stricto (58.5%) C. albicans (34.1%)...
Despite Noroviruses (NV, previously "Norwalk-like viruses") being a leading cause of acute gastroenteritis outbreaks, the impact NV infection is at present unknown and little information available about strains circulating in Italy. In April 2002 an outbreak occurred province Bari (South-east Italy), involving several households.A retrospective cohort study was performed order to assess risk factors associated with illness. All households where case were included study. Faecal specimens...
Following the publication of Italian Guidelines for control and prevention legionellosis an environmental clinical surveillance has been carried out in Southeastern Italy. The aim study is to identify risk factors disease, so allowing better programming necessary measures. During period January 2000 - December 2009 was by water sampling 129 health care facilities (73 public 56 private hospitals) 533 buildings within community (63 apartments, 305 hotels, 19 offices, 4 churches, 116 gyms, 3...
According to Italian Ministerial Decree No. 185 of 12 June 2003, water is considered suitable for irrigation if levels fecal bacteria (i.e., Escherichia coli and Salmonella) are within certain parameters. The detection other microorganisms not required. aim this study determine the bacteriological quality groundwater used occurrence enteric viruses (Norovirus, Enterovirus, Rotavirus, Hepatovirus A), compare presence with indicators. A total 182 wells was analyzed. Widespread contamination...
This study represents the first investigation of microbiological groundwater pollution as a function aquifer type and season for Apulia region southern Italy. Two hundred seven wells were randomly selected from those monitored by Regional Agency Environmental Protection emergency use. Both compulsory (Escherichia coli, Total Coliform, Enterococci) optional (Pseudomonas aeruginosa, Salmonella spp., Heterotrophic Plate Count at 37 22 °C) parameters assessed regularly these wells. Groundwater...
Nosocomial infections cause significant morbidity and mortality worldwide, the pathogenic organisms responsible for such can develop resistance to antimicrobial agents. Understanding activity of disinfectants against clinical environmental bacterial isolates is therefore crucial. We analysed in vitro five products (phenolic compounds, didecyldimethylammonium chloride (DDAC), sodium hypochlorite, isopropanol + ammonium compounds (IACs), hydrogen peroxide) 187 strains comprising isolates, as...
A screening survey of the presence aflatoxin M(1) (AFM(1)) was carried out on 265 samples cheese made from cow, buffalo, goat, sheep, sheep-goat milk collected in Apulia region (Southern Italy). Selected included unripened, medium and long-term ripened cheeses. AFM(1) found 16.6% analyzed samples. The highest positive incidence for cheeses, especially those milk, while buffalo cheeses tested consistently negative. Our results show that level contamination by dairy products Region are lower...
Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor that activates phagocytic NADPH-oxidase. The effect of HP-NAP on the production tissue (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type (u-PA) by human blood mononuclear cells (MNC) was evaluated using functional immunological assays mRNA analysis. induced time- dose-dependent increases in TF PAI-2, with maximal at 300 nmol/L (>15-fold increase antigens). No changes u-PA were observed. When...
The safety of groundwater resources is a serious issue, particularly when these are the main source water for drinking, irrigation and industrial use in coastal areas. In Italy, 85% used by public underground origin. aim this report to analyze factors that make vulnerable. Soil characteristics filtration capacity can promote or hinder diffusion environmental contaminants. Global climate change influences prevalence degree contamination. Anthropic pressure causes considerable exploitation...
Although direct contact is considered the main mode of transmission SARS-CoV-2, environmental factors play an important role. In this study, we evaluated presence SARS-CoV-2 on bus and train surfaces. From buses, took samples from following areas: handrails used to enter or exit bus, stop request buttons handles next seats. trains, sampled surfaces were train, door open/close buttons, seats, tables toilet handles. was detected 10.7% tested overall, 19.3% 2% (p < 0.0001). On most contaminated...
Methicillin-resistant S. aureus (MRSA) is a pathogen spread not only in the hospital environment but also community and amongst livestock (LA-MRSA). LA-MRSA can be transmitted to humans that live close contact with MRSA-colonized animals, human colonization and/or infection has been reported worldwide, particularly among those involved farming. In this study authors evaluated prevalence of MRSA healthy carriers who worked food industry Apulia, Southern Italy.Nasal swabs were taken from pasta...
As a complement to clinical disease surveillance, the monitoring of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in wastewater can be used as an early warning system for impending epidemics. This study investigated dynamics SARS-CoV-2 untreated with respect trend coronavirus 2019 (COVID-19) prevalence Southern Italy. A total 210 samples were collected between May and November 2020 from 15 Apulian treatment plants (WWTP). The concentrated accordance standard World Health...
The World Health Organization's Action Framework for tuberculosis elimination in low-tuberculosis incidence countries includes the screening active and latent selected high-risk groups, including health care workers. In this context, medical profession students, exposed to nosocomial transmission during training clinical rotations, are target populations screening. No updated data available on practice knowledge of students Italy.Within activities Italian Study Group Hospital Hygiene Society...
The gram-positive pathogen Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and responsible for high morbidity mortality worldwide. A major feature pneumococcal an abundant neutrophil infiltration. In this work we observed that R6 nonencapsulated S. strain induced a higher oxidative burst in neutrophils compared with its capsulated progenitor D39, by triggering NADPH oxidase to produce more reactive oxygen intermediates (ROI) interfering kinase signalling...
The Ministry of Health published in November 2012 the "National guidelines for prevention and clinical management dental trauma individuals during their developmental age". aim this study is to verify knowledge among parents children primary schools plan corrective actions.The was carried out filling an anonymous questionnaire distributed enrolled three schools.Despite publication National guidelines, survey results confirm parents' lack awareness, skills relation trauma.This will allow a...
Retinoids have been shown to modulate several functions of mononuclear phagocytes. We investigated the in vitro effect all‐ trans ‐retinoic acid (ATRA) on production two major fibrinolytic components, urokinase‐type plasminogen activator (u‐PA) and PA inhibitor 2 (PAI‐2), by human blood cells (MNC). ATRA caused a dose‐dependent (range 0.01–10 μ m ) accumulation PAI‐2 antigen activity into cell culture medium, with maximal increase (about 5‐fold over control) at concentration 1–10 ....
Candidemia is a major infectious complication in neonatal patients. The isolation of yeasts from blood still the "gold standard" for its diagnosis, but other laboratory markers (i.e., circulating antigens) have been studied with varying specificities and sensitivities. aim this study was to evaluate role procalcitonin diagnosis candidemia patients at high risk. To verify if use different commercial methods can highlight dissimilar results sensitivity and/or specificity, determination serum...
Hepatitis A is a common infectious disease worldwide that was endemic in many regions of Southern Italy, such as Apulia region. After large hepatitis outbreak occurred between 1996 and 1997, an active-free immunization program targeted to new-borns adolescents started. The aim this study investigate the seroprevalence adult Apulian population 18 years after introduction, order evaluate risk new epidemics onset. carried out from May 2011 June 2012 among blood donors Department Transfusion...
The antiphospholipid antibodies (aPL) increase the risk of developing thrombotic events and may coexist with a variety autoimmune diseases. They can be detected chronically or temporarily in patients infectious diseases, during drug therapy, cases cancer. A event aPL detection is known as syndrome (APS) diagnostic criteria include presence lupus anticoagulant (LA), anticardiolipin (aCL) β2-glycoprotein-1(aβ2GPI) antibodies. Other autoantigens recognized APS are phosphatidylserine (aPS),...
Nosocomial environmental contamination plays an important role in the transmission of several health care-associated pathogens. Control surfaces can reduce risk cross-infection hospitals. The aim our study is to evaluate disinfectant effectiveness hydrogen peroxide and silver ions, against nosocomial multidrug-resistant strains, when it's used directly on surfaces.Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa 15442 same clinical isolates were selected suspension or clean dirty...