A5034122128- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Multiple Myeloma Research and Treatments
- Immune Response and Inflammation
- Oral microbiology and periodontitis research
- Autoimmune Bullous Skin Diseases
- Proteoglycans and glycosaminoglycans research
- Salivary Gland Disorders and Functions
- Monoclonal and Polyclonal Antibodies Research
- Oral and gingival health research
- Cystic Fibrosis Research Advances
- Metal complexes synthesis and properties
- Antimicrobial Peptides and Activities
- Hematological disorders and diagnostics
- Cancer Treatment and Pharmacology
- Blood disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Chemokine receptors and signaling
- Retinoids in leukemia and cellular processes
- S100 Proteins and Annexins
- Chemotherapy-induced organ toxicity mitigation
- Skin and Cellular Biology Research
- Ion channel regulation and function
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Pneumonia and Respiratory Infections
University of Bari Aldo Moro
2011-2022
University of Catania
1985
University of Verona
1983
University of Padua
1983
Abstract Aberrant microRNA (miR) expression has an important role in tumour progression, but its involvement bone marrow fibroblasts of multiple myeloma patients remains undefined. We demonstrate that a specific miR profile parallels the transition from monoclonal gammopathy undetermined significance (MGUS) to myeloma. Overexpression miR‐27b‐3p and miR‐214‐3p triggers proliferation apoptosis resistance via FBXW7 PTEN/AKT/GSK3 pathways, respectively. Transient transfection inhibitors...
Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation formation, and stimulating re-epithelialization. Hyaluronan is component ECM its anti-inflammatory effects properties enhancing wound closure are well known. In this study, we examined Aminogam gel, new pharmacological preparation suggested to improve healing, composed hyaluronic acid, proline, lysine, glycine leucine, on human fibroblasts. Results show that...
Hydrogen sulfide is a toxic metabolite released by several bacterial agents under anaerobic conditions. In the present paper, we investigated effects of on polymorphonuclear cell (PMN) apoptosis, mechanism suggested for limiting potential neutrophils in inflammatory sites. We showed that 1 mM (concentration not conditioning PMN viability) able to enhance apoptotic fate human granulocytes increasing: i) number cells containing pyknotic nuclei, ii) internucleosomal cleavage, and, iii)...
Interactions of multiple myeloma (MM) cells with endothelial (ECs) enhance angiogenesis and MM progression. Here, we investigated the role Notch signaling in cross talk between ECs enabling angiogenesis. MMECs showed higher expression Jagged1/2 ligands, activated Notch1/2 receptors, Hes1/Hey1 target genes than from monoclonal gammopathy undetermined significance patients, suggesting that homotypic activation pathway occurs MM. co-cultured triggered these through a cell-to-cell...
Retinoids are known to modulate several functions of mononuclear phagocytes. We have studied the effect retinyl acetate (RAc) and retinoic acid (RA) on production procoagulant activity (PCA) by human peripheral blood cells stimulated with endotoxin (1 microgram/ml, 4 or 20 h at 37 degrees C). Both compounds caused a dose-dependent reduction in expression cell-associated PCA (from 86 less than 10% control range concentration comprised between 0.1 100 microM). This was also observed when were...
Regulatory T cells (Tregs) are essential for maintenance of self-tolerance; however, tumor can exploit the tolerance to escape immune system. We investigated Tregs frequency in patients with multiple myeloma (MM) and those monoclonal gammopathy undetermined significance (MGUS), found that CD4(+) FoxP3(+) CD8(+) were significantly increased MM correlated active phase. Both subsets expanded cocultures CD3(+) lymphocytes fresh CD138(+) plasma or RPMI8226 U266 cell lines functioned as natural...
Apoptosis provides a mechanism for clearance of unwanted cells in variety situations which programmed or physiological cell death occurs; but the premature defensive could promote infection, inflammation and concomitant disease. We detected high values apoptosis polymorphonuclear (PMN) elicited from crevicular sulci smokers affected by adult periodontitis. To learn more about effects nicotine on periodontal environment, we studied its ability to modulate two phagocytic lines, PMN mononuclear...
Polymorphonuclear cells (PMN) of gingival sulcus play an important role in host defense against periodontal tissue-invading bacteria, but their phagocytic activity is conditioned by several virulence factors released oral pathogens. In this report we have studied the influence sulfide, a toxic bacterial metabolite, on main PMN functions: chemotaxis, degranulation and oxidative burst. exposed to sodium sulfide (up 2 mM) used as source H2S showed depression calcium-dependent cytoskeleton...
The gram-positive pathogen Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and responsible for high morbidity mortality worldwide. A major feature pneumococcal an abundant neutrophil infiltration. In this work we observed that R6 nonencapsulated S. strain induced a higher oxidative burst in neutrophils compared with its capsulated progenitor D39, by triggering NADPH oxidase to produce more reactive oxygen intermediates (ROI) interfering kinase signalling...
lntracellular pathogens have evolved effective mechanisms in order to survive an intracellular environment, thus avoiding destruction by phagocytic cells. In this regard, a correlation between resistance killing and expression of pathogenic potency has been established.In report, we studied the interaction human polymorphonuclear cells (PMN) two gram-negative microorganisms, Afipia felis Rochalimaea henselae, which belong α-2 subgroup class Proteobacteria. A. previously proposed as causative...
Apoptosis provides a mechanism for clearance of unwanted cells in variety situations which programmed or physiological cell death occurs; but the premature defensive could promote infection, inflammation and concomitant diseases. Polymorphonuclear (PMN) gingival sulcus play an important role host defense against periodontal tissue‐invading bacteria, their phagocytic activity is conditioned by several virulence factors released oral pathogens. Polyamines derived from bacteria frequently occur...