A5044902238- Weed Control and Herbicide Applications
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Agriculture, Plant Science, Crop Management
- Helicobacter pylori-related gastroenterology studies
- Cystic Fibrosis Research Advances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Galectins and Cancer Biology
- Horticultural and Viticultural Research
- Protease and Inhibitor Mechanisms
- Biological Control of Invasive Species
- Allelopathy and phytotoxic interactions
- Chronic Lymphocytic Leukemia Research
- Nematode management and characterization studies
- Plant Physiology and Cultivation Studies
- Agronomic Practices and Intercropping Systems
- Cell Adhesion Molecules Research
- Garlic and Onion Studies
- Eosinophilic Esophagitis
- Retinoids in leukemia and cellular processes
- S100 Proteins and Annexins
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
University of Bari Aldo Moro
2006-2023
University of Padua
2002
Ollscoil na Gaillimhe – University of Galway
1996
University of Reggio Calabria
1988
Policlinico Universitario di Catania
1988
Medica (Italy)
1982
Infection by Helicobacter pylori causes an acute inflammatory response followed a chronic infection of the human gastric mucosa. A neutrophil-activating protein (HP-NAP) has been identified in H. pylori, and its role immune is currently under investigation. Here, we show that HP-NAP induces β-hexosaminidase release interleukin-6 production peritoneal mast cells, two actions which are completely inhibited pertussis toxin. We also polarized epithelial cell monolayers translocates from apical...
The role of colony stimulating factors (CSFs) in cystic fibrosis (CF) circulating neutrophils has not been thoroughly evaluated, considering that the neutrophil burden lung inflammation these subjects is very high. aim this study was to assess granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) levels CF patients various clinical conditions how cytokines impact on activation priming neutrophils. G-CSF GM-CSF were measured sputum serum samples stable (n = 21) with acute...
We have already formulated solid lipid nanoparticles (SLNs) in which the combination of neurotransmitter dopamine (DA) and antioxidant grape-seed-derived proanthocyanidins (grape seed extract, GSE) was supposed to be favorable for Parkinson's disease (PD) treatment. In fact, GSE supply would reduce PD-related oxidative stress a synergic effect with DA. Herein, two different methods DA/GSE loading were studied, namely, coadministration aqueous phase DA GSE, other approach consisting physical...
Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor that activates phagocytic NADPH-oxidase. The effect of HP-NAP on the production tissue (TF), plasminogen activator inhibitor-2 (PAI-2), and urokinase-type (u-PA) by human blood mononuclear cells (MNC) was evaluated using functional immunological assays mRNA analysis. induced time- dose-dependent increases in TF PAI-2, with maximal at 300 nmol/L (>15-fold increase antigens). No changes u-PA were observed. When...
Infection by Helicobacter pylori causes an acute inflammatory response followed a chronic infection of the human gastric mucosa. A neutrophil-activating protein (HP-NAP) has been identified in H.pylori, and its role immune is currently under investigation. Here, we show that HP-NAP induces beta-hexosaminidase release interleukin-6 production peritoneal mast cells, two actions which are completely inhibited pertussis toxin. We also polarized epithelial cell monolayers translocates from apical...
Treatment of acute lymphoblastic leukaemia (ALL) with L-asparaginase (L-asp) may be associated thrombotic complications, but the pathogenetic mechanisms thrombus formation and persistence remain unclear. We studied procoagulant activity (PCA) peripheral blood mononuclear cells some components plasma fibrinolytic system in 10 children ALL undergoing remission induction therapy which includes L-asp. Mononuclear obtained 14 days after starting L-asp treatment generated significantly higher...
Abstract This paper reports a survey on the weed flora and seed bank in an almond orchard sited Apulia region (Southern Italy), where following soil management practices have been compared for over 30 yrs: no-tillage, keeping totally weed-free throughout year by using pre-emergence herbicides to prevent plant emergence or post-emergence case of weeds already emerged; with herbicides; mowing natural spring; cover cropping, faba bean sown November green manured springtime; conventional...
The treatment of cystic fibrosis (CF) patients homozygous for the F508del mutation with Orkambi®, a combination corrector (lumacaftor) and potentiator (ivacaftor) mutated CFTR protein, resulted in some amelioration respiratory function. However, great variability clinical response was also observed. aim this study to evaluate Orkambi® small cohort F508del/F508del (n = 14) terms laboratory parameters, including ex vivo activity mononuclear cells (MNCs), during 12-month treatment. Patients...
Retinoids are known to modulate several functions of mononuclear phagocytes. We have studied the effect retinyl acetate (RAc) and retinoic acid (RA) on production procoagulant activity (PCA) by human peripheral blood cells stimulated with endotoxin (1 microgram/ml, 4 or 20 h at 37 degrees C). Both compounds caused a dose-dependent reduction in expression cell-associated PCA (from 86 less than 10% control range concentration comprised between 0.1 100 microM). This was also observed when were...
Abstract Mononuclear phagocytes exhibit complex interactions with cancer cells and might contribute to fibrin formation associated malignancy through the production of procoagulant activity (PCA). We have studied PCA peritoneal macrophages in 8 patients advanced (stages III or IV) ovarian from regional lymph nodes 14 limited I II) uterine cancer; lymph‐node benign gynecological tumors were used as reference cell populations. In all patients, blood monocytes was also studied. Peritoneal...
Abstract Aim The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) potentiator ivacaftor (Kalydeco®) improves clinical outcome in G551D cystic fibrosis (CF) patients. Here, we have investigated whether has a impact on non‐G551D gating mutations and function of circulating leukocytes as well. Methods Seven patients were treated with evaluated at baseline, 1‐3 6 months. Besides systemic inflammatory parameters, mononuclear cells (MNC) for CFTR‐dependent chloride efflux by...
A three-year experiment was conducted in order to evaluate the effects of three different soil management systems a vineyard (organic mulch with exhausted olive pomace at 6 cm thick, weed mowing and herbicide application) on physicochemical characteristics flora.A variety data collected throughout trial, such as analyses, surveys phytotoxicity tests.The results show that able increase K Mg content exerted good control over weeds, also had an effect flora composition.Although further research...
Apoptosis provides a mechanism for clearance of unwanted cells in variety situations which programmed or physiological cell death occurs; but the premature defensive could promote infection, inflammation and concomitant disease. We detected high values apoptosis polymorphonuclear (PMN) elicited from crevicular sulci smokers affected by adult periodontitis. To learn more about effects nicotine on periodontal environment, we studied its ability to modulate two phagocytic lines, PMN mononuclear...
Different Helicobacter pylori lipopolysaccharides (LPSs) and LPS-derivatives were studied for their ability to induce the production of procoagulant activity (PCA) plasminogen activator inhibitor type 2 (PAI-2) by human blood mononuclear leukocytes. Smooth (S)- rough (R)-form LPSs caused a similar increase in cell-associated PCA (tissue factor) PAI-2 antigen release. Both effects potentiated fetal bovine serum via CD14-mediated mechanism. The potency H. was approximately 1000-fold lower than...
In seeking more specific biomarkers of the cystic fibrosis (CF) lung inflammatory disease that would be sensitive to antibiotic therapy, we sought evaluate gene expression profiles neutrophils in CF patients before treatment comparison with non-CF healthy individuals and after treatment. Genes involved neutrophil-mediated inflammation, i.e. chemotaxis, respiratory burst, apoptosis, granule exocytosis, were targets this study. Microarray analysis was carried out blood airway from control...
The gram-positive pathogen Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and responsible for high morbidity mortality worldwide. A major feature pneumococcal an abundant neutrophil infiltration. In this work we observed that R6 nonencapsulated S. strain induced a higher oxidative burst in neutrophils compared with its capsulated progenitor D39, by triggering NADPH oxidase to produce more reactive oxygen intermediates (ROI) interfering kinase signalling...
Retinoids have been shown to modulate several functions of mononuclear phagocytes. We investigated the in vitro effect all‐ trans ‐retinoic acid (ATRA) on production two major fibrinolytic components, urokinase‐type plasminogen activator (u‐PA) and PA inhibitor 2 (PAI‐2), by human blood cells (MNC). ATRA caused a dose‐dependent (range 0.01–10 μ m ) accumulation PAI‐2 antigen activity into cell culture medium, with maximal increase (about 5‐fold over control) at concentration 1–10 ....
Summary: Résumé: Zusammenfassung Weed density was sampled in a number of quadrats five crops and at eight locations Italy. For every location species crop weed, mean/variance pair calculated. The relationship between these two parameters significantly influenced by and, to lesser extent, site, but not weed. goodness fit the negative binomial distribution samples assessed. Its k exponent estimated on basis observed variance/mean regression. A good found for weed populations with fewer than 10...