A5090566753- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Vitamin D Research Studies
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Vitamin C and Antioxidants Research
- Antibiotic Use and Resistance
- Infant Nutrition and Health
- Pediatric Hepatobiliary Diseases and Treatments
- Pregnancy and preeclampsia studies
- Diagnosis and treatment of tuberculosis
- Estrogen and related hormone effects
- Viral gastroenteritis research and epidemiology
- Mast cells and histamine
- Heme Oxygenase-1 and Carbon Monoxide
- Fungal Infections and Studies
- Infectious Aortic and Vascular Conditions
- Reproductive System and Pregnancy
- Grief, Bereavement, and Mental Health
- Bacterial Infections and Vaccines
- Legionella and Acanthamoeba research
- Nosocomial Infections in ICU
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2025
Helmholtz Centre for Environmental Research
2023-2024
Leipzig University
2024
University of Bari Aldo Moro
2020-2023
Cefiderocol is a new cephalosporin displaying against extensively resistant (XDR) Gram-negative bacteria. We report our experience with cefiderocol-based combination therapies as “rescue” treatments in immunocompromised or critically ill patients post-surgical infections who had failed previous regimens. A total of 13 were treated from 1 September 2020 to 31 March 2021. In total, 5/13 (38%) classified ill, due severe COVID-19 lung failure; 4/13 (31%) and subjects solid organ transplantation...
Evidence-based, standard antibiotic therapy for ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is a relevant unmet clinical need in the intensive care unit (ICU). We aimed to evaluate effectiveness of first-line with old and novel CRAB active antibiotics monomicrobial VAP CRAB. A prospective, observational study was performed mixed non-COVID-19 ICU. The primary outcome measure failure upon targeted therapy. Features independently...
Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality limited treatment. The aim of this study is to compare effectiveness and safety colistin-based versus cefiderocol-based therapies for CRAB-BSI.This a retrospective observational enrolling patients monomicrobial CRAB-BSIs treated colistin or cefiderocol from 1 January 2020, 31 December 2022. 30-day all-cause rate was the primary outcome. A Cox regression analysis...
Probiotic administration has become common practice in neonatal intensive care units (NICUs) to prevent necrotizing enterocolitis (NEC) and promote gut health preterm infants. While probiotics are generally considered safe, rare cases of probiotic-related sepsis have been reported. We present a case Lactobacillus rhamnosus infant, highlighting the challenges involved its diagnosis. The infant developed symptoms on 13th day probiotic treatment. Laboratory analyses, including MALDI-TOF,...
Aim: Infections by Klebsiella pneumoniae carbapenemase (KPC)-producing K. represent a major challenge because of limited treatment strategies. New β-lactam/β-lactamase inhibitor associations may help to deal with this challenge. The aim study is evaluate the in vitro susceptibility KPC-producing for meropenem/vaborbactam comparison ceftazidime/avibactam against. Materials and methods: Twenty-eight strains isolated from blood cultures were evaluated. Testing was performed E-test gradient...
The COVID-19 pandemic has undone years of progress in providing essential TB services and controlling the burden. Italy, a low burden country, an incidence 7.1 cases per 100,000 people. To control spreading Italy is critical to investigate characteristics patients with worst outcomes highest risk adverse events related antituberculosis therapy. Therefore, we conducted large retrospective study admitted Clinic Infectious Diseases University Bari, order describe clinical presentation factors...
Since December 2019, the Coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has spread from China, becoming a pandemic. Bacterial and fungal co-infections may lead to increase in COVID-19 severity with decrease patients survive. The aim of this work was evaluate bacterial admitted ICU comparison recovered pre-COVID-19 era order understand whether pandemic had changed incidence overinfections ICU. In fact, epidemiological data should guide choice...
Meropenem/vaborbactam (M/V) is a new carbapenem-carbapenemase inhibitor combination drug active against extensively resistant Gram-negative pathogens. Studies about its efficacy and place in therapy are limited "real-life" no data available for deep site infections, like vascular graft infections. We present case of patient successfully treated with M/V thoracic aorta infection, placed traumatic penetrating aortic ulcer, due to an KPC-producing Klebsiella pneumoniae ceftazidime/ avibactam....
Legionnaires' disease is a severe form of pneumonia caused by the inhalation or aspiration water droplets contaminated with Legionella pneumophila and other species. These bacteria are commonly found in natural habitats man-made systems. significant public health problem, especially healthcare settings where patients may be exposed to environmental sources. Nosocomial outbreaks have been reported worldwide, leading high morbidity mortality rates, increased costs. This study aimed compare,...
In our experimental study we explored the impact of maternal reduced heme oxygenase-1 (HO-1) gene (