A5036096353- Effects and risks of endocrine disrupting chemicals
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Air Quality and Health Impacts
- RNA modifications and cancer
- Dermatology and Skin Diseases
- Cancer-related gene regulation
- Pharmacogenetics and Drug Metabolism
- Pregnancy and preeclampsia studies
- Immunotoxicology and immune responses
- T-cell and B-cell Immunology
- Reproductive Physiology in Livestock
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Toxic Organic Pollutants Impact
- Pharmaceutical studies and practices
- Animal Diversity and Health Studies
- Immune Response and Inflammation
- Meat and Animal Product Quality
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
Helmholtz Centre for Environmental Research
2016-2025
Leipzig University
1999-2024
Helmholtz Association of German Research Centres
2014
Croatian Veterinary Institute
2000
Abstract Background Vitamin D levels are known to be associated with atopic disease development; however, existing data controversial. The aim of this study was investigate whether corresponding maternal and cord blood vitamin outcomes in early infancy. Methods Within the LINA cohort (Lifestyle environmental factors their Influence on Newborns Allergy risk), 25( OH ) measured samples 378 mother–child pairs during pregnancy at birth. Information about children's manifestations first 2 years...
Abstract Background: Regulatory T cells ( regs) with stable FOXP3 expression are characterized by a specific demethylated region in the gene reg‐specific region, TSDR ). The aim of this study was to analyse influence prenatal factors on cord blood reg numbers, as detected changes demethylation, and subsequent risk for allergic diseases. Methods: Analyses were performed within LINA samples from pregnant women (34th gestational week) n = 346 mother–child pairs). numbers via DNA demethylation ....
Abstract Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects has been discussed controversially recent years. Here we investigate the effect of prenatal on childhood overweight by combining epidemiological data from a mother–child cohort with experimental approaches. Mothers reporting use paraben-containing cosmetic have elevated urinary concentrations. For butyl (BuP) positive...
Prenatal and early postnatal exposures to environmental factors are considered responsible for the increasing prevalence of allergic diseases. Although there is some evidence allergy-promoting effects in children because exposure plasticizers, such as phthalates, findings previous studies inconsistent lack mechanistic information.We investigated effect maternal phthalate on asthma development subsequent generations their underlying mechanisms, including epigenetic alterations.Phthalate...
Article24 March 2016Open Access Transparent process Environment-induced epigenetic reprogramming in genomic regulatory elements smoking mothers and their children Tobias Bauer orcid.org/0000-0002-4961-3639 Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany Search for more papers by this author Saskia Trump Department Environmental Immunology, Helmholtz Centre Leipzig - UFZ, Leipzig, Naveed Ishaque Heidelberg Personalized Oncology, DKFZ-HIPO,...
Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association tobacco smoking with epigenetic changes at single CpGs in blood. However, biological relevance often only marginal methylation remains unclear. Comparing genome-wide CpG three recently reported epidemiological datasets, two obtained on whole blood and peripheral mononuclear cells (PBMCs), it becomes evident that majority...
Exposure to endocrine-disrupting chemicals can alter normal physiology and increase susceptibility non-communicable diseases like obesity. Especially the prenatal early postnatal period is highly vulnerable adverse effects by environmental exposure, promoting developmental reprogramming epigenetic alterations. To obtain a deeper insight into role of bisphenol A (BPA) exposure in children's overweight development, we combine epidemiological data with experimental models BPA-dependent DNA...
Endocrine disrupting chemicals (EDCs) possess the capability to interfere with endocrine system by binding hormone receptors, for example on immune cells. Specific effects have already been described individual substances, but impact of exposure chemical mixtures during pregnancy maternal regulation, placentation and fetal development is not known. In this study, we aimed investigate combined two widespread EDCs bisphenol A (BPA) benzophenone-3 (BP-3) at allowed concentrations crucial...
Many recent epigenetic studies report that cigarette smoking reduces DNA methylation in whole blood at the single CpG site cg19859270 within GPR15 gene.Within two independent cohorts, we confirmed differentially expression of gene when smokers and non-smokers subjects are compared. By validating protein cellular level, found observed decreased this white cells (WBC) is mainly caused by high proportion CD3+GPR15+ expressing T peripheral blood. In current smokers, percentage GPR15+ among CD3+...
Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma.Our aim was to investigate the impact of gene variants associated with oxidative stress inflammation on childhood asthma.Traffic-related pollution, asthma, wheeze, variant, potential confounder data were pooled across six birth cohorts. Parents reported physician-diagnosed asthma wheeze from 7-8 years age (confirmed by pediatric allergist two cohorts). Individual...
Abstract Psychological stress during pregnancy increases the risk of childhood wheeze and asthma. However, transmitting mechanisms remain largely unknown. Since epigenetic alterations have emerged as a link between perturbations in prenatal environment an increased disease we used whole genome bisulfite sequencing (WGBS) to analyze changes DNA methylation mothers their children related psychosocial assessed its role development child. We evaluated genomic regions altered level due maternal...
In the last decades, per- and poly-fluoroalkyl substances (PFAS), widely used industrial chemicals, have been in center of attention because their omnipotent presence water soils worldwide. Although efforts made to substitute long-chain PFAS towards safer alternatives, persistence humans still leads exposure these compounds. immunotoxicity is poorly understood as no comprehensive analyses on certain immune cell subtypes exist. Furthermore, mainly single entities not mixtures assessed....
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption adipocyte differentiation, interference with obesity mechanisms, and impairment insulin- glucose homeostasis. Substitute compounds are increasingly emerging but not sufficiently investigated.We aimed investigate the mode action BPA four its substitutes during differentiation human preadipocytes adipocytes their molecular interaction peroxisome...
Immune homeostasis is key to guarantee that the immune system can elicit effector functions against pathogens and at same time raise tolerance towards other antigens. A disturbance of this delicate balance may underlie or least trigger pathologies. Endocrine disrupting chemicals (EDCs) are increasingly recognized as risk factors for dysregulation. However, immunotoxic potential specific EDCs their mixtures still poorly understood. Thus, we aimed investigate effect bisphenol (BPA)...
ABSTRACT Problem Although it is still uncertain whether Severe Acute Respiratory Coronavirus (SARS‐CoV‐2) placental infection and vertical transmission occur, inflammation during early pregnancy can have devastating consequences for gestation itself the growing fetus. If how SARS‐CoV‐2‐specific immune cells negatively affect placenta functionality unknown. Method of study We stimulated peripheral blood mononuclear (PBMCs) from women reproductive age with SARS‐CoV‐2 peptides cocultured them...
Abstract Background Associations between traffic‐related air pollution ( TRAP ) and childhood atopic dermatitis AD remain inconsistent, possibly due to unexplored gene‐environment interactions. The aim of this study was examine whether a potential effect on prevalence in children is modified by selected single nucleotide polymorphisms SNP s) related oxidative stress inflammation. Methods Doctor‐diagnosed up age 2 years at 7‐8 years, as well symptoms assessed using parental‐reported...
It was postulated that 3D cell culture models more accurately reflect the complex tissue physiology and morphology in comparison to 2D monolayers. Currently, there is a shortage of well-characterized easily maintainable high-throughput experimental human placenta. Here, we characterized three different cultures (e.g., spheroids) derived from trophoblast lines studied their functionality primary fetal trophoblasts placental tissue. The spheroid growth rates JEG3, BeWo HTR8/SVneo were similar...
Childhood asthma is a result of complex interaction genetic and environmental components causing epigenetic immune dysregulation, airway inflammation impaired lung function. Although different microarray based EWAS studies have been conducted, the impact regulation in development still widely unknown. We therefore applied unbiased whole genome bisulfite sequencing (WGBS) to characterize global DNA-methylation profiles asthmatic children compared healthy controls.Peripheral blood samples 40...
Leucocytes vary in type and number during the lifespan of a corpus luteum. The aim this study was to determine whether there is an increase lymphocytes macrophages as result local proliferation. Bovine corpora lutea were classified into stages development, secretion regression. A new double immunolabelling method established for nuclear Ki-67 antigen (a marker cell proliferation) leucocyte surface antigens (detection CD2-, CD3-, CD4-, CD8-positive CD14-positive monocytes). Differential...