A5027020883- Effects and risks of endocrine disrupting chemicals
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- T-cell and B-cell Immunology
- Computational Drug Discovery Methods
- Immunotoxicology and immune responses
- Cancer Risks and Factors
- Gestational Trophoblastic Disease Studies
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Genetics, Bioinformatics, and Biomedical Research
- Multiple and Secondary Primary Cancers
- Neuroendocrine Tumor Research Advances
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Research Studies
Leipzig University
2024
Helmholtz Centre for Environmental Research
2021-2024
Capital Medical University
2021-2022
Beijing Obstetrics and Gynecology Hospital
2020-2022
McMaster University
2022
Endocrine disrupting chemicals (EDCs) possess the capability to interfere with endocrine system by binding hormone receptors, for example on immune cells. Specific effects have already been described individual substances, but impact of exposure chemical mixtures during pregnancy maternal regulation, placentation and fetal development is not known. In this study, we aimed investigate combined two widespread EDCs bisphenol A (BPA) benzophenone-3 (BP-3) at allowed concentrations crucial...
Immune homeostasis is key to guarantee that the immune system can elicit effector functions against pathogens and at same time raise tolerance towards other antigens. A disturbance of this delicate balance may underlie or least trigger pathologies. Endocrine disrupting chemicals (EDCs) are increasingly recognized as risk factors for dysregulation. However, immunotoxic potential specific EDCs their mixtures still poorly understood. Thus, we aimed investigate effect bisphenol (BPA)...
Background: Endometriosis is a common gynecological disorder that usually causes infertility, pelvic pain, and ovarian masses. This study aimed to mine the characteristic genes of endometriosis, explore regulatory mechanism potential therapeutic drugs based on whole transcriptome sequencing data resources from public databases, providing theoretical basis for diagnosis treatment endometriosis. Methods: The five eutopic (EU) ectopic (EC) endometrium samples were obtained Beijing Obstetrics...
The precision and expense of biological research have grown in inverse proportion during decades ongoing bioinformatics technology development, with steadily increasing accuracy gradually decreasing spending.In the meantime, demand for data analysis has skyrocketed questions that remained unanswered since relatively mature sector.During 1990s 2000s, considerable advances sequencing technology, combined lower costs, resulted an exponential increase demand.The emergence 'Big Data' posed new...
Abstract BACKGROUND: Data on the survival outcome between laparoscopic and open abdominal radical hysterectomy is limited in patients with endometrial cancer involving cervix. METHODS: We performed a retrospective 1:1 matched observational study who had their cervix involved by during 2010–2018 period Beijing Obstetrics Gynecology Hospital China. All enrolled underwent cancer-directed through approach or surgery followed until 3 years after surgery. The primary was rates of disease-free...
Abstract Background: Neuroendocrine carcinoma of the cervix is rare and aggressive disease, which prognosis information effectiveness therapies unclear. Methods: A retrospective study using data from SEER database for first diagnosed patients was conducted. We performed univariate multivariate Cox models to screen independent prognostic factors overall survival. Subgroup analysis sensitive were further study, then again analyses regression based on sensitivity set. Results: total 250 cases...