A5068079227- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Mast cells and histamine
- Maternal and Perinatal Health Interventions
- Heme Oxygenase-1 and Carbon Monoxide
- Pregnancy-related medical research
- Pregnancy and Medication Impact
- Food Allergy and Anaphylaxis Research
- Birth, Development, and Health
- Social Policies and Family
- Per- and polyfluoroalkyl substances research
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Vascular Malformations and Hemangiomas
- Ovarian function and disorders
- Sepsis Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Kawasaki Disease and Coronary Complications
- Genetics, Aging, and Longevity in Model Organisms
- Hypertrophic osteoarthropathy and related conditions
- Wnt/β-catenin signaling in development and cancer
Otto-von-Guericke University Magdeburg
2015-2024
Helmholtz Centre for Environmental Research
2020-2024
Leipzig University
2022-2024
Hospital of the University of Pennsylvania
2021-2023
Kiel University
2022
Centre Hospitalier Universitaire de Toulouse
2020
University Hospital of Geneva
2018
University Hospital of Basel
2013
University of Basel
1995-2013
TU Dresden
2012
Methylphenidate and 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') are widely misused psychoactive drugs. increases brain dopamine norepinephrine levels by blocking the presynaptic reuptake transporters. MDMA releases serotonin, through same Pharmacodynamic interactions of methylphenidate likely. This study compared pharmacodynamic pharmacokinetic effects administered alone or in combination healthy subjects using a double-blind, placebo-controlled, crossover design. did not enhance...
Endocrine disrupting chemicals (EDCs) possess the capability to interfere with endocrine system by binding hormone receptors, for example on immune cells. Specific effects have already been described individual substances, but impact of exposure chemical mixtures during pregnancy maternal regulation, placentation and fetal development is not known. In this study, we aimed investigate combined two widespread EDCs bisphenol A (BPA) benzophenone-3 (BP-3) at allowed concentrations crucial...
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating placentation uterine remodeling. We exposed pregnant female mice 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from...
Implantation of the fertilized egg depends on coordinated interplay cells and molecules that prepare uterus for this important event. In particular, regulatory T (Tregs) are key regulators as their ablation hinders implantation by rendering hostile embryo. addition, adoptive transfer Tregs can avoid early abortion in mouse models. However, it is still not defined which mechanisms underlie Treg function during period. Cells innate immune system have been reported to support implantation, part...
Abstract Intrauterine growth restriction (IUGR) is caused by insufficient remodeling of spiral arteries (SAs). The mechanism underlying the relevance natural killer cells (NKs) and mast (MCs) for SA its effects on pregnancy outcome are not well understood. We show that NK depletion arrested without affecting pregnancy. MC resulted in abnormally remodeled SAs IUGR. Combined absence NKs MCs substantially affected impaired fetal growth. found α-chymase cell protease (Mcpt) 5 mediates apoptosis...
The onset of pregnancy implies the appearance a new organ, placenta. One main function placenta is to supply oxygen fetus via hemoproteins. In this review, we highlight importance enzyme heme oxygenase-1 (HO-1) for be established and maintained. HO-1 expression pivotal promote placental fetal development, thus determining success pregnancy. deletion gene Hmox1 in mice leads inadequate remodeling spiral arteries suboptimal placentation followed by intrauterine growth restriction (IUGR)...
Intrauterine growth restriction (IUGR) is a serious pregnancy complication with short- and long-term health consequences. The mechanisms underlying this condition are not well understood. Animal models the basis for understanding causes of IUGR developing useful therapeutic strategies. Here, we aimed to ascertain in utero fetuses from NK (natural killer cells)/MC (mast cells)-deficient mothers that give birth growth-restricted pups determine time point at which starts. We used high frequency...
Uterine natural killer cells (uNKs) and mast (uMCs) are of crucial importance for spiral artery (SA) remodelling placentation. Mice deficient both NKs MCs including uNKs uMCs show markedly impaired SA remodeling their fetuses growth-retarded. In contrast, the absence either or results in only minor impairment. This suggests that can compensate effects on vice versa. To test this hypothesis, we assessed uNK numbers uMC-deficient mice as well uMC uNK-depleted mice. Notably,...
An equilibrium between proinflammatory and anti-inflammatory immune responses is essential for maternal tolerance of the fetus throughout gestation. To study participation fetal tissue-derived factors in this delicate balance, we analyzed effects human chorionic gonadotropin (hCG) on murine Treg cells Th17 vitro , pregnancy outcomes, placental growth, blood flow velocities remodeling uterine vascular bed vivo . Compared with untreated CD4 + CD25 T cells, hCG increased frequency upon...
Chemotherapy is an important treatment modality for many patients with advanced cancer. Recent data revealed that certain chemotherapeutic agents differentially affect maturation, cytokine production and T-cell stimulatory capacity of dendritic cells (DCs), which play a crucial role in the induction antitumor immunity. Whereas most reports are based on mouse or human monocyte-derived DCs, studies investigating direct effect drugs native DCs rather limited. Here, we evaluated impact various...
The enzyme heme oxygenase-1 (HO-1) is pivotal in reproductive processes, particularly placental and vascular development. This study investigated the role of HO-1 its byproduct, carbon monoxide (CO), trophoblastic spheroid implantation. In order to deepen our understanding during implantation, we conducted vivo experiments on virgin pregnant mice, aiming unravel cellular molecular mechanisms. Using siRNA, was knocked down JEG-3 BeWo cells spheroids were generated with or without CO...
Endocrine disruptoring chemicals (EDCs) are natural and synthetic compounds found ubiquitously in the environment that interfere with hormonal-immune axis, potentially impacting human health reproduction. Exposure to EDCs has been associated numerous risks, such as neurodevelopmental disorders, metabolic syndrome, thyroid dysfunction, infertility, cancers. Nevertheless, current approach establishing causality between disease outcomes limitations. Epidemiological experimental research on...
We study the classical scattering of a point particle from one and two rotating hard discs in plane, as an idealization off target. The system displays regular or chaotic behaviour depending on value only constant motion: Jacobi integral. present results transition between terms periodic orbits system. For certain ranges integral dynamics is fully hyperbolic. number symbols needed to characterize invariant set different each those intervals may become arbitrarily high.
Y-box binding protein 1 (YB-1) is pivotal for the regulation of cancerogenesis and inflammation. However, its involvement in pregnancy processes such as fetal placental development remains to be elucidated. We studied Ybx1 (YB-1)+/− heterozygous intercrossings compared them YB-1+/+ wild-type (WT) combinations. Additionally, we generated trophoblast-specific YB-1-deficient mice by pairing FVB Cyp19-Cre females YB-1fl/fl males. YB-1fl/fl-paired WT served controls. Serial vivo ultrasound...
Ultrasound imaging is a widespread method used to detect organ anomalies and tumors in human animal tissues. The non-invasive, harmless, painless, the application easy, fast, can be done anywhere, even with mobile devices. During pregnancy, ultrasound standardly closely monitor fetal development. technique important assess intrauterine growth restriction (IUGR), pregnancy complication short- long-term health consequences for both mother fetus. Understanding process of IUGR indispensable...