A5035173732- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Adipose Tissue and Metabolism
- biodegradable polymer synthesis and properties
- Pesticide Exposure and Toxicity
- Language, Metaphor, and Cognition
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Proteomics Techniques and Applications
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Complex Systems and Decision Making
- Categorization, perception, and language
- Health and Medical Research Impacts
- Electrochemical sensors and biosensors
- Air Quality and Health Impacts
- Polymer Science and PVC
- Public-Private Partnership Projects
- Lanthanide and Transition Metal Complexes
- Capital Investment and Risk Analysis
- Biomedical and Engineering Education
- Educational Strategies and Epistemologies
- Heavy Metal Exposure and Toxicity
- Child and Animal Learning Development
- Analytical Chemistry and Sensors
- Climate Change and Health Impacts
Innsbruck Medical University
2022-2024
Helmholtz Centre for Environmental Research
2020-2024
Universität Innsbruck
2023
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of plasticizer di-(2-ethylhexyl)-phthalate (DEHP), search for safe substitutes gained importance. Focusing on master regulator adipogenesis and functionality, peroxisome proliferator-activated receptor gamma (PPARγ), we evaluated 20 alternative plasticizers well their metabolites binding activation PPARγ assessed effects...
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption adipocyte differentiation, interference with obesity mechanisms, and impairment insulin- glucose homeostasis. Substitute compounds are increasingly emerging but not sufficiently investigated.We aimed investigate the mode action BPA four its substitutes during differentiation human preadipocytes adipocytes their molecular interaction peroxisome...
The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in manufacture plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, asthma, for which inflammation described be a driving factor. emerging alternative 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on immune system. Here, we investigated DINCH naturally occurring metabolite...
In 2012, 20 key questions related to hazard and exposure assessment environmental health risks of pharmaceuticals personal care products in the natural environment were identified. A decade later, this article examines current level knowledge around one lowest-ranking at that time, number 19: "Can nonanimal testing methods be developed will provide equivalent or better data compared with vivo methods?" The inclusion alternative replace, reduce, refine animal within regulatory context risk...
Growing evidence suggests that exposure to certain metabolism-disrupting chemicals (MDCs), such as the phthalate plasticizer DEHP, might promote obesity in humans, contributing spread of this global health problem. Due restriction on use phthalates, there has been a shift safer declared substitutes, including diisononyl-cyclohexane-1,2-dicarboxylate (DINCH). Notwithstanding, recent studies suggest primary metabolite monoisononyl-cyclohexane-1,2-dicarboxylic acid ester (MINCH), induces...
Adipokines and apolipoproteins are key regulators potential biomarkers in obesity associated diseases their quantitative assessment is crucial for functional analyses to understand disease mechanisms. Compared routinely used ELISAs, multiple reaction monitoring (MRM)-based mass spectrometry allows multiplexing detection of proteins which antibodies not available. Thus, we established an MRM method quantify 9 adipokines 10 human serum. We optimized sample preparation by depleting the two most...
An increasing body of evidence identifies pollutant exposure as a risk factor for cardiovascular disease (CVD), while CVD incidence rises steadily with the aging population. Although numerous experimental studies are now available, mechanisms through which lifetime to environmental pollutants can result in not fully understood. To comprehensively describe and understand pathways leads cardiotoxicity, systematic mapping review available toxicological is needed. This protocol outlines...