A5040624949- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Reproductive biology and impacts on aquatic species
- Pesticide and Herbicide Environmental Studies
- Pharmacological Effects and Assays
- Antibiotics Pharmacokinetics and Efficacy
- Analytical chemistry methods development
- Aquaculture disease management and microbiota
- Effects and risks of endocrine disrupting chemicals
- Water Treatment and Disinfection
- Reproductive Health and Contraception
- Pharmacogenetics and Drug Metabolism
- Malaria Research and Control
- Antibiotic Use and Resistance
- Analytical Chemistry and Chromatography
- Systemic Lupus Erythematosus Research
- Neurological Complications and Syndromes
- Agricultural safety and regulations
- Pesticide Residue Analysis and Safety
- Tuberous Sclerosis Complex Research
- Cervical Cancer and HPV Research
- Renal cell carcinoma treatment
- Fish Ecology and Management Studies
- Cytokine Signaling Pathways and Interactions
- Pesticide Exposure and Toxicity
Pfizer (United States)
2010-2024
Worcestershire Health and Care NHS Trust
2009
Kentucky Science Center
1991
Abstract For many older pharmaceuticals, chronic aquatic toxicity data are limited. To assess risk during development, scale-up, and manufacturing processes, acute physicochemical properties need to be leveraged reduce potential long-term impacts the environment. Aquatic were pooled from daphnid, fish, algae studies for 102 active pharmaceutical ingredients (APIs) evaluate relationship between predicted no-effect concentrations (PNECs) derived tests. The relationships n-octanol/water...
A SETAC Pellston Workshop® "Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)" was held in February 2016 Pensacola, Florida, USA. The primary objective of the workshop to provide advice, based on current scientific understanding, regulators policy makers; aim being make considered, informed decisions whether select an ecotoxicological hazard- or a risk-based approach regulating given endocrine-disrupting substance (EDS) under review. additionally...
The pharmaceutical manufacturing industry, via the AMR Industry Alliance, has developed and implemented steps to help minimize potential impact of on spread antimicrobial resistance (AMR). One these was publish predicted no-effect concentrations (PNECs) serve as targets for antibiotic wastewater effluent risk assessments aimed protect environmental receptors mitigate against resistance. Concentrations below which adverse effects in environment are not expected occur were first published 2018...
In 2012, 20 key questions related to hazard and exposure assessment environmental health risks of pharmaceuticals personal care products in the natural environment were identified. A decade later, this article examines current level knowledge around one lowest-ranking at that time, number 19: "Can nonanimal testing methods be developed will provide equivalent or better data compared with vivo methods?" The inclusion alternative replace, reduce, refine animal within regulatory context risk...
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an mode action (MoA) with a plausible link to population-relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoints although some also include mechanistic endpoints, subcellular-through-organ level, which can help establish MoA. However, between these and population-level effects is often unclear. The case studies endocrine-active substances (EAS) (tributyltin,...
The present study examined the bioconcentration of 2 basic pharmaceuticals: verapamil (a calcium channel blocker) and clozapine (an antipsychotic compound) in fresh water fishes, fathead minnow catfish. In 4 separate factor (BCF) experiments (2 chemicals × 1 exposure concentration fishes), catfish were exposed to 190 μg/L 419 (500 nominal) or 28.5 40 (50 nominal), respectively. Bioconcentration with consisted 28 d uptake 14 depuration, whereas tests conducted on involved a minimized test...
Abstract The conservation of common physiological systems across vertebrate classes suggests the potential for certain pharmaceuticals, which have been detected in surface waters, to produce biological effects nontarget vertebrates such as fish. However, previous studies assessing compounds fish not taken into account metabolism and elimination. This study aimed assess if propranolol, a β‐adrenergic receptor antagonist or β‐blocker, could modulate EROD activity (indicative CYP1A activity)...
Abstract A study was conducted to understand the potential for ibuprofen impact hypothalamus‐pituitary‐gonadal endocrine axis resulting in disruption of fish reproduction. The Good Laboratory Practice according Organisation Economic Co‐operation and Development 229 Protocol, Fish Short‐Term Reproduction Assay, extended an additional 4 d evaluate hatching success F1 generation. Test organisms were exposed nominal test concentrations 0.5, 2.4, 11.5, 55.3, 265.4 µg ibuprofen/L a negative...
17α-Trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains trenbolone acetate estradiol benzoate. As part environmental assessment use data were generated to characterize effects 17α-trenbolone on reproduction freshwater fish. These substances known endocrine disruptors, so purpose testing was not clarify these properties but identify concentrations representing population-relevant for risk characterization. The...
Two studies to examine the effect of waterborne clofibric acid (CA) on growth-rate and condition rainbow trout were conducted using accepted regulatory tests (Organisation for Economic Co-operation Development [OECD] 215). The first study (in 2005) showed significant reductions after 21 d exposure (21-d growth lowest-observed-effect concentration [LOEC] = 0.1 µg/L, 21-d LOEC µg/L) that continued 28 d. Growth rate was reduced by approximately 50% (from 5.27 2.67% per day), while fish in a...
Renal cell carcinoma (RCC) is characterised by lack of early warning signs. The classic triad (palpable mass, haematuria and flank pain) occurs in less than 15% cases paraneoplastic syndromes develop 10-40%, often preceding the detection neoplasm. This report describes a 51-year-old woman who displayed manic symptomatology was investigated due to anaemia. RCC diagnosed her psychiatric remitted after nephrectomy.