A5042749890- Dementia and Cognitive Impairment Research
- Water Quality and Resources Studies
- Soil Geostatistics and Mapping
- Alzheimer's disease research and treatments
- Pesticide Residue Analysis and Safety
- Genetic Associations and Epidemiology
- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Advanced Statistical Methods and Models
- Schizophrenia research and treatment
- Water Quality Monitoring and Analysis
- Folate and B Vitamins Research
- Data Analysis with R
- Pregnancy and preeclampsia studies
- Statistical Methods and Bayesian Inference
- International Environmental Law and Policies
- Statistical Methods and Inference
- History and advancements in chemistry
- Treatment of Major Depression
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Water resources management and optimization
- Dermatologic Treatments and Research
- Simulation Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
VA Puget Sound Health Care System
2011-2023
Geriatric Research Education and Clinical Center
2008-2023
VA Northwest Network
2008-2021
Seattle University
1988-2019
Mental Illness Research, Education and Clinical Centers
2008-2018
University of Washington
1987-2018
Seattle Institute for Biomedical and Clinical Research
2018
VA Portland Health Care System
2010-2017
Washington University in St. Louis
2017
Uniformed Services University of the Health Sciences
2013
The authors conducted a 15-week randomized controlled trial of the alpha-1 adrenoreceptor antagonist prazosin for combat trauma nightmares, sleep quality, global function, and overall symptoms in active-duty soldiers with posttraumatic stress disorder (PTSD) returned from deployments to Iraq Afghanistan.Sixty-seven were randomly assigned treatment or placebo 15 weeks. Drug was titrated based on nightmare response over 6 weeks possible maximum dose 5 mg midmorning 20 at bedtime men 2 10...
The therapeutic imperative for Alzheimer disease (AD) and Parkinson (PD) calls discovery validation of biomarkers. Increased cerebrospinal fluid (CSF) tau decreased amyloid (A) beta42 have been validated as biomarkers AD. In contrast, there is no CSF biomarker PD. We our proteomics-discovered multianalyte profile (MAP) in from 95 control subjects, 48 patients with probable AD, 40 An optimal 8-member MAP agreed expert diagnosis 90 subjects (95%), 36 AD (75%), 38 PD (95%). This consisted the...
Background Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that critical to organization of neuronal networks and synaptic plasticity, especially in the hippocampus. We tested hypothesis reduced CSF BDNF associated with age-related cognitive decline. Methodology/Principal Findings, Conclusions/Significance concentration BDNF, Aβ42 total tau were measured 128 cognitively normal adults (Normals), 21 patients Alzheimer's disease (AD), nine Mild Cognitive...
The ɛ4 allele of the human apolipoprotein E gene (APOE) is a well-proven genetic risk factor for late onset form Alzheimer's disease (AD). However, biological mechanisms through which contributes to pathophysiology are incompletely understood. three common allel es APOE, ɛ2, ɛ3 and ɛ4, defined by two single nucleotide polymorphisms (SNPs) that reside in coding region exon 4, overlaps with well-defined CpG island (CGI). Both SNPs change not only protein codon but also quantity dinucleotides,...
Abstract For many older pharmaceuticals, chronic aquatic toxicity data are limited. To assess risk during development, scale-up, and manufacturing processes, acute physicochemical properties need to be leveraged reduce potential long-term impacts the environment. Aquatic were pooled from daphnid, fish, algae studies for 102 active pharmaceutical ingredients (APIs) evaluate relationship between predicted no-effect concentrations (PNECs) derived tests. The relationships n-octanol/water...
High-resolution computed tomography (HRCT) has been suggested as a potential outcome surrogate for cystic fibrosis (CF) lung disease. An important attribute of valid is that the reflects true clinical outcomes.We performed this study to validate HRCT, proposed measure CF disease, against outcome, number respiratory tract exacerbations occurring in 2 yr, and assess correlation CT scores pulmonary function tests (PFTs) with outcome.CTs PFTs were on 6- 10-yr-old children at beginning end 2-yr...
Polymorphisms of the serotonin transporter gene (SERT) have been associated with mental illness. In people long-term medical conditions, variants 5-HTTLPR and STin2 VNTR polymorphisms SERT shown to confer a heightened vulnerability comorbid depression.To determine whether 5-HTTLPR, VNTR, rs25531 are poststroke depression (PSD) in stroke survivors.A case-control study which survivors were screened for depressive symptoms assigned either depressed group or nondepressed group.Outpatient...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDistribution and mobility of selenium other trace elements in shallow groundwater the western San Joaquin Valley, CaliforniaSteven J. Deverel Steven P. MillardCite this: Environ. Sci. Technol. 1988, 22, 6, 697–702Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/es00171a013https://doi.org/10.1021/es00171a013research-articleACS PublicationsRequest reuse...
Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evidence suggests that circuits may be involved in reinforcement relapse. After a positive pilot study, the authors tested α-1 adrenergic receptor antagonist prazosin to treat larger sample.Ninety-two participants with but without posttraumatic stress were randomly assigned receive or placebo 12-week double-blind study. Medication was titrated dosing schedule of 4 mg morning,...
Introduction: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality life in men with mild cognitive impairment (MCI) low serum T levels. Methods: A total 351 community-dwelling were screened, 37 evidenced both MCI whom 27 agreed for further screening. Twenty-two met all inclusion/exclusion criteria enrolled a 6-month randomized, double-blind, placebo-controlled study. Results: Total levels significantly increased group. No significant changes...
The ε4 allele of the apolipoprotein E gene (APOE) is associated with increased risk and earlier age at onset in late Alzheimer's disease (AD). Other factors, such as expression level protein (apoE), have been postulated to m
Many cognitively normal older adults have underlying neuropathologic changes of Alzheimer's disease (AD), vascular brain injury (VBI), or Lewy body (LBD), which confer an increased risk dementia. The current study focused on the association between multiple indices and performance specific cognitive domains in a community sample adults. Of 438 participants Adult Changes Thought population-based aging who were autopsied, 363 subjects had testing at their final visit included. Associations...
<h3>Importance</h3> Age-related cognitive decline among older individuals with normal cognition is a complex trait that potentially derives from processes of aging, inherited vulnerabilities, environmental factors, and common latent diseases can progress to cause dementia, such as Alzheimer disease vascular brain injury. <h3>Objective</h3> To use cerebrospinal fluid (CSF) biomarkers gain insight into this trait. <h3>Design, Setting, Participants</h3> Secondary analyses an academic...
Abstract Objectives: To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Iraqi (OIF), New Dawn (OND) Veterans with without a self-reported history of blast-related mild traumatic brain injury (mTBI). Methods: Sixty-one OEF/OIF/OND Veterans, including mTBI (mTBI group; n =42) TBI (control =19) completed the Memory for Intentions Test, measure (PM), two measures (RM), California Verbal Learning Test-II Brief Visuospatial Test-Revised. Results: group...
To examine potential disease-modifying effects of statin drugs, we conducted a 12-month randomized, placebo-controlled clinical trial simvastatin in cognitively normal adults using change CSF Alzheimer disease biomarkers as primary outcome measure.Participants were 45-64 years old and statin-naive with cognition or mildly elevated cholesterol. Forty-six participants completed the 1-year study per protocol (25 21 placebo group). Simvastatin was titrated to 40 mg/d. Aβ42, total tau, p-tau181...
Increases in the quantity or impact of noradrenergic signaling have been implicated pathophysiology posttraumatic stress disorder (PTSD). This increased may result from norepinephrine (NE) release, altered brain responses to NE, a combination both factors. Here, we tested hypothesis that Veterans reporting history trauma exposure would show an association between NE and mental health symptoms commonly observed after trauma, as compared who did not report exposure, consistent with possibility...
Engrav, Loren H. M.D.; Gottlieb, Jourdan R. Millard, Steven P. Ph.D.; Walkinshaw, Marcus D. Heimbach, David M. Marvin, Janet A. R.N., M.N. Author Information
As concern over the effects of trace amounts pollutants has increased, so need for statistical methods that deal appropriately with data include values reported as “less than” detection limit. It become increasingly common water quality to censored reflect more than one limit a single analyte. For such multiply sets, standard (for example, compare analyte concentration in two areas) are not valid. In cases, from biostatistical field survival analysis applicable. Several two‐sample rank tests...