A5032876184- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Infective Endocarditis Diagnosis and Management
- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Infections and bacterial resistance
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Otolaryngology and Infectious Diseases
- Legionella and Acanthamoeba research
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- HIV Research and Treatment
- Breast Implant and Reconstruction
- Microbial infections and disease research
- Plant Pathogenic Bacteria Studies
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Enterobacteriaceae and Cronobacter Research
Istituto Superiore di Sanità
1994-2025
Università Campus Bio-Medico
2016-2025
Campus Bio Medico University Hospital
2008-2023
University of Messina
2012
University of Padua
2007
Centers for Disease Control and Prevention
1999-2000
Epidemic Intelligence Service
2000
National Center for Infectious Diseases
2000
Princeton University
1945
Abstract Background Stenotrophomonas maltophilia is emerging as one of the most frequently found bacteria in cystic fibrosis (CF) patients. In present study, phenotypic and genotypic traits a set 98 isolates S. obtained from clinical (CF non-CF patients) environmental sources were comparatively evaluated. Results exhibited high level genomic diversity both CF group, thus possibly allowing this bacterium to expand its pathogenic potentials. Strains sharing same pulsotype infected different...
Background: Streptococcus pyogenes or group A streptococcus (GAS) is an important human pathogen responsible for a broad range of infections, from uncomplicated to more severe and invasive diseases with high mortality morbidity. Epidemiological surveillance has been crucial detect changes in the geographical temporal variation disease pattern; this purpose M protein gene (emm) typing most widely used genotyping method, than 200 emm types recognized. Molecular epidemiological data have also...
On the basis of available data with regard to chemical and physical properties "substrate" luciferin (LH(2)) enzyme, luciferase (A), kinetic derived both from reaction in extracts Cypridina, luminescence intact bacteria, fundamental reactions involved phenomenon bioluminescence have been schematized. These provide a satisfactory for interpreting known characteristics system, as well theoretical chemistry control its over-all velocity relation various factors. factors, here studied...
ABSTRACT Group B streptococci (GBS) comprising three different sets of isolates (31 invasive, 36 noninvasive, and 24 colonizing isolates) were collected in Italy during the years 2002 to 2005. Clonal groups established by pulsed-field gel electrophoresis (PFGE), selected studied multilocus sequence typing (MLST). GBS also characterized classical molecular techniques for serotyping protein gene antibiotic resistance profiling. Some serotypes significantly associated with a particular isolate...
Abstract Background Treatment of cystic fibrosis-associated lung infections is hampered by the presence multi-drug resistant pathogens, many which are also strong biofilm producers. Antimicrobial peptides, essential components innate immunity in humans and animals, exhibit relevant vitro antimicrobial activity although they tend not to select for strains. Results Three α-helical BMAP-27 BMAP-28 bovine origin, artificial P19(9/B) peptide were tested, comparatively Tobramycin, their...
Approximately 40–60% of group A streptococcal (GAS) isolates are capable opacifying sera, due to the expression sof (serum opacity factor) gene. The emm (M protein gene) and 5′ sequences were obtained from a diverse set GAS reference strains clinical isolates, correlated with M serotyping anti-opacity-factor testing results. Attempts amplify serotypes or types historically associated opacity-factor-negative phenotype negative, except for emm12 strains, which found contain highly conserved...
The present study was carried out to understand the adaptive strategies developed by Stenotrophomonas maltophilia for chronic colonization of cystic fibrosis (CF) lung. For this purpose, 13 temporally isolated strains from a single CF patient chronically infected over 10-year period were systematically characterized growth rate, biofilm formation, motility, mutation frequencies, antibiotic resistance, and pathogenicity. Pulsed-field gel electrophoresis (PFGE) showed time presence two...
The intrinsic antibiotic resistance of Stenotrophomonas maltophilia, along with its ability to form biofilm both on abiotic surfaces and host tissues, dramatically affects the efficacy therapy. In this work, 85 S. maltophilia strains isolated in several hospital central Italy from clinical settings were evaluated for their genetic relatedness (by pulsed-field gel electrophoresis, PFGE), formation microtiter plate assay), planktonic Kirby-Bauer disk diffusion technique). population showed a...
The COVID-19 pandemic has profoundly impacted global health, leading to extensive research focused on developing strategies enhance outbreak response and mitigate the disease’s severity. In aftermath of pandemic, attention shifted towards understanding addressing long-term health implications, particularly in individuals experiencing persistent symptoms, known as long COVID. Research into potential interventions alleviate COVID symptoms intensified, with a focus support immune function...
Carbapenem-Resistant Gram-Negative Bacteria, including Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (ICUs) Italy. This prospective observational study evaluated the epidemiology, management, microbiological characterization, outcomes hospital-acquired CRE or CRPA treated selected ICUs The included patients with due to 20 from June 2021 February 2023. primary endpoint was 1-year incidence CRE/CRPA infections. Secondary...
Abstract Objectives To characterize the optrA-, cfr(D)- and vanA-carrying linear plasmids detected in three MDR enterococcal clinical isolates. Methods Enterococcus faecium (868), E. (1001) faecalis (2048), which were linezolid- vancomycin-resistant due to presence of optrA, cfr(D) vanA genes, tested for their susceptibility several antibiotics. Characterization genetic elements carrying antibiotic resistance genes ST determination achieved using WGS data. The plasmid topology was evaluated...
To assess the genetic diversity of pneumococci causing serious disease within United States, restriction profiles 3 penicillin-binding protein (PBP)-gene amplicons and dhf amplicon were examined in 241 recent sterile-site isolates from 7 population centers. This analysis provided markers useful for epidemiologic studies was generally predictive resistances to β-lactam antibiotics trimethoprim-sulfamethoxazole. Eight pulsed-field gel electrophoresis (PFGE) types, each representing 3–40...
ABSTRACT Staphylococcus pseudintermedius is a veterinary pathogen that has seldom been described as an agent of human disease. Features this probably underreported coagulase-positive species are depicted here through the description graft-versus-host disease-related wound infection caused by multidrug-resistant strain.
Background. Invasive group A streptococcal (GAS) infections are a cause of serious morbidity and high mortality. There is need for simple, effective antimicrobial regimen that could be used to prevent invasive GAS disease in risk situations. To assess azithromycin as chemoprophylactic agent, we evaluated its efficacy eradication oropharyngeal (OP) impact on the nasopharyngeal (NP) colonization rate macrolide-resistant Streptococcus pneumoniae. Methods. We obtained OP NP swabs pneumococcus...