A5004893151- Metabolism and Genetic Disorders
- HIV Research and Treatment
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- HIV/AIDS Research and Interventions
- Biochemical and Molecular Research
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Peroxisome Proliferator-Activated Receptors
- Pharmaceutical studies and practices
- Fatty Acid Research and Health
- Viral gastroenteritis research and epidemiology
- Cervical Cancer and HPV Research
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Heart Failure Treatment and Management
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Animal Virus Infections Studies
- Mitochondrial Function and Pathology
Università Campus Bio-Medico
2015-2024
Campus Bio Medico University Hospital
2006-2024
University of Milan
1999-2013
San Raffaele University of Rome
2013
Ospedale San Paolo
1998-2012
Hospital Universitario Ramón y Cajal
2006
Policlinico Umberto I
2003
State Key Laboratory of Virology
2003
Sapienza University of Rome
1992-2000
Columbia University
1999
Abstract Objectives To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. determine association between viral reactivation in-hospital mortality, Intensive Care Unit Bloodstream infection (ICU–BSI), ventilator-associated pneumonia (VAP). Design Observational retrospective cohort study. Setting Unit. Patients From November 2020 to May 2021, one hundred twenty patients with severe...
<h3>AIM</h3> A follow up study of developmental quotient (DQ) at 24 months toddlers whose diets in early infancy differed fatty acid composition, and whom an association between diet DQ was observed 4 months. <h3>METHODS</h3> 81 were distributed among three groups according to type diet: standard infant formula (SFo, n = 30); long chain polyunsaturated (LC-PUFA) enriched (LCPFo, 26); human milk (HM, 25). assessed by Brunet-Lézine's psychomotor test. subgroup (n 20; SFo 8; LCPFo 6; HM 6)...
The COVID-19 pandemic has profoundly impacted global health, leading to extensive research focused on developing strategies enhance outbreak response and mitigate the disease’s severity. In aftermath of pandemic, attention shifted towards understanding addressing long-term health implications, particularly in individuals experiencing persistent symptoms, known as long COVID. Research into potential interventions alleviate COVID symptoms intensified, with a focus support immune function...
There have been reports of in-vitro interferon (IFN)-mediated antiviral activity against the hepatitis C virus (HCV) through microRNAs (miRNAs). The main aim this study was to evaluate expression several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after vitro IFN-treatment and PBMCs patients with chronic (CHC) before 12 hours first injection pegylated IFN alpha. We demonstrated that these could be recorded collected...
We explored the comprehension of informed consent in 77 cancer patients previously enrolled randomised phase II or III clinical trials, between March and July 2011, at San Raffaele Scientific Institute Milano. asked participants to complete an ad hoc questionnaire analysed their answers. Sixty-two per cent understood purpose nature trial they were participating in; 44% study procedures 40% correctly listed least one major risks complications related participation trial. identified three...
Despite a large measles outbreak is taking place in WHO European region, currently no data are available on immunization coverage the asylum seeker and migrants hosted this area.Two hundred fifty-six upon their arrival Italy March, April May 2016 were screened for virus IgG antibodies by chemiluminescence immunoassay (Liaison XL analyzer, Diasorin, Italy). The susceptibility cohort, differences between official country reported observed impact of current seekers largest Asylum Seeker centres...
Resistance of tumor cells to the antigrowth activity several cytotoxic compounds has been associated with expression so-called multidrug resistance protein or P-glycoprotein. This article addresses question whether such could also affect sensitivity HIV AZT. Our data indicate that this possibility does exist. In fact, multidrug-resistant CEM VBL100 cells, which express high levels P-glycoprotein, are less sensitive both antiproliferative and antiviral action Additionally, our suggest...
✓ The criteria by which acromegalic patients are considered “cured” after surgical therapy still controversial. Since the abnormal growth hormone (GH) increase administration of some agents has been demonstrated to be characteristic tumoral somatotrophs, its disappearance surgery may taken as an index complete removal tumor. Serum GH increases thyrotropin-releasing (TRH, 200 µg intravenously), gonadotropin-releasing (Gn-RH, 100 and sulpiride (100 mg intramuscularly) injected during dopamine...
The continuous emergence of SARS-CoV-2 variants and subvariants poses significant public health challenges. latest designated subvariant JN.1, with all its descendants, shows more than 30 mutations in the spike gene. JN.1 has raised concerns due to genomic diversity potential enhance transmissibility immune evasion. This study aims analyse molecular characteristics JN.1-related lineages (JN.1*) identified Italy from October 2023 April 2024 evaluate neutralization activity against a subsample...
SUMMARY It is known that IFN therapy can induce the development of anti-IFN antibodies. In order to evaluate biological and clinical significance both neutralizing (NA) non-neutralizing (binding) antibodies, 123 patients with chronic hepatitis C treated recombinant IFN-α were examined. Among them, 15 positive for NA 24 binding The kinetics appearance show that, in general, they develop early during first 3 months treatment. Moreover, seem be clinically relevant, since may responsible...
Liver cirrhosis is characterized by a severe acquired reduction of LAL-activity, the precise causes and consequences which need to be further addressed. DBS-determined lysosomal enzyme activities seem affected white blood cell platelet counts, specificity these tests can reduced when applied determined populations, such as cirrhotics.
We have previously shown that multidrug-resistant cells expressing the multidrug transporter P-glycoprotein are less sensitive to antiviral activity of AZT. Subsequently, we addressed question whether AZT itself is able induce cellular resistance drug. Indeed, CEM propagated in presence increasing concentrations become resistant antigrowth and but do not express detectable level P-glycoprotein. Sensitivity these other compounds, such as vinblastine, vincristine, ddI, ddC remained unchanged,...
The aim of the study was to explore illness experience individuals affected by phenylketonuria (PKU) and its differences in different patient age groups.A qualitative-interpretative methodology used through in-depth interviews. Textual data were explored using principles grounded theory.Forty-seven patients participated study, aged from 10 >25 years old. results suggested age-related PKU experience: (1) a paradox, either feel normal but isolated social context, or be while participating...
Enterobacter microorganisms cause important bacterial infections in humans. Recently, carbapenem resistant isolates carrying the blaKPC gene were described and their clonal transmission different nosocomial outbreaks reported. In this study, relative numbers of species, antimicrobial susceptibility along 3 years observation identification ability two most common MALDI-TOF platforms evaluated. A clustering analysis was performed to identify changes microbial population within environment....
According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specificity intraepithelial neoplasia grade 2 or more (CIN2+) lesions. The study aimed assess whether HPV Selfy (Ulisse BioMed - Trieste, Italy), full-genotyping test detects differentiates 14 high-risk (HR-HPV) types, meets the criteria screening described in on...
Strict control of phenylalanine intake is the main dietary intervention for phenylketonuric children. Whether other dietary‐related factors improve clinical outcome treated children in neurodevelopmental terms, however, remains unexplored. We retrospectively compared intelligence quotient (IQ) score 26 school‐age who were either breastfed or formula fed 20‐40 days prior to intervention. Children had been as infants scored significantly better (IQ advantage 14.0 points, p = 0.01) than fed. A...
The mechanisms responsible for the hematopoietic failure in human immunodeficiency virus type 1 (HIV-1)-infected patients are still unknown. Several findings indicate that vitro proliferative potential of precursor cells from AIDS is reduced. changes seen bone marrow (BM) morphology and defective BM functions associated with cytopenias have both been proposed as explanations. In treated highly active antiretroviral therapy (HAART) an immune reconstitution increased whole blood cell counts...
The antitussive efficacy and tolerability of dropropizine its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 evaluable for 254 efficacy. Patients randomly received either 1 mg/kg or 2 orally, three times daily 3 days. There statistically significant decreases the frequency coughing spells nocturnal awakenings after both treatments ( P < 0.001). Gastrointestinal symptoms mild two groups; somnolence was twice as frequent group (10.3% vs 5.3%)...
Objective: To characterize anal human papillomavirus (HPV) infections in terms of genotype prevalence and type-specific DNA load HIV-positive men. Design: men attending the colo-proctological clinic a University Hospital Rome were recruited prospectively from November 2004 to July 2007. HIV-negative outpatients same over period used as control group. Methods: Anal brushings tested for HPV-DNA using polymerase chain reactions direct sequencing; copies measured most positive samples. HPV data...
To evaluate whether a relationship exists in hospital admissions for respiratory conditions children with outdoor pollution the Southwest Milan, Italy.Daily count of asthma, upper or lower diseases (LRD) occurred among aged < =14 years at San Paolo Hospital during 2007-2008 was recorded. Pollutants included particular matter <10 microm diameter, ozone, carbon monoxide (CO) and nitrogen dioxide (NO(2)), reported on same day admission 1 up to 5 days before admission. The moving weekly average...
The patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C > G single nucleotide polymorphism (SNP) has been associated with steatosis and fibrosis in previous NAFLD populations which cirrhotic patients were very poorly represented. Since not all evolve to cirrhosis, we investigated the specific risk of cirrhosis conferred by carrying this SNP.Three groups studied: NASH-cirrhosis; biopsy-proven non-cirrhotic NAFLD; healthy subjects undergoing medicine check-ups. Epidemiological,...