A5058401263- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Ocular Surface and Contact Lens
- Medical and Biological Ozone Research
- Biosensors and Analytical Detection
- Poxvirus research and outbreaks
- Infections and bacterial resistance
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Infection Control and Ventilation
- Ocular Infections and Treatments
- Neonatal Respiratory Health Research
- Mosquito-borne diseases and control
- Reproductive tract infections research
- Hepatitis Viruses Studies and Epidemiology
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020-2025
University of Turin
2020-2025
Fondazione Ricerca Molinette
2021
A.P. Giannini Foundation
2021
Azienda Ospedaliera Treviglio
2021
Abstract Purpose Does controlled ovarian stimulation (COS) and progesterone (P) luteal supplementation modify the vaginal endometrial microbiota of women undergoing in vitro fertilization? Methods Fifteen underwent analysis at two time points: during a mock transfer performed phase cycle preceding COS, fresh embryo (ET). A swab distal extremity ET catheter tip were analyzed using next-generation 16SrRNA gene sequencing. Heterogeneity bacterial was assessed according to both Bray-Curtis...
Rapid and sensitive screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential to limit the spread global pandemic we are facing. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) currently used for clinical diagnosis SARS-CoV-2 infection using nasopharyngeal swabs, tracheal aspirates, or bronchoalveolar lavage (BAL) samples. Despite high sensitivity qRT-PCR method, false negative outcomes might occur, especially in patients with a...
The aim of this study was to investigate the prevalence ceftazidime/avibactam (CZA) resistance among carbapenemase-producing Enterobacterales (CPE) blood culture isolates as well performance main carbapenemase phenotypic detection methods identify KPC variants associated with CZA resistance.Non-duplicate CPE strains isolated from cultures during 2018-2020 were tested for antimicrobial susceptibility. Molecular testing used carbapenemase-producers. Strains harbouring blaKPC and a minimum...
Respiratory infections, particularly of the upper airways, play an important role in human pathologies, with them being most common cause disease both children and adults, a relevant impact on healthcare systems. Pathogen identification is critical patients, molecular assays used methods. Herein, epidemiology respiratory viruses Northwestern Italy was studied by using tract syndromic panel over period eight years, from January 2016 to December 2023, order evaluate COVID-19 pandemic this...
Introduction: Respiratory syncytial virus (RSV) is the main etiological agent in pediatric lower respiratory tract infections. The limited availability of therapeutic options for severe clinical cases associated with RSV infection makes prophylactic interventions a priority containment. aim current study was to evaluate epidemiology Piedmont population and consequences containment measures applied during pandemic on viral circulation immediate medium-term post-pandemic phase. Methods: This...
Bacteria are the most common causative agents of ocular infections. Treatment with topical broad-spectrum antibiotics is recommended in severe cases. However, antibiotic resistance has become a major concern recent years, although generally effective treating Antibacterial compound screening performed to identify alternative therapeutic options antibiotics. The aim this study was assess vitro antimicrobial activity an ophthalmic solution containing ozonated oil. Strains bacterial species...
ABSTRACT Human Cytomegalovirus (HCMV) infection is life-threatening for immunocompromised patients. Quantitative molecular assays on whole blood or plasma are the gold standard diagnosis of invasive HCMV and monitoring antiviral treatment in individuals at risk disease. For these reasons, an accurate standardization toward WHO 1st International Standard among different centers diagnostic kits represents effort better clinical management HCMV-positive Herein, we evaluate, first time,...
Purpose: To evaluate the antimicrobial effectiveness of a liposomal ozonized oil solution used as home therapy in patients undergoing cataract surgery. Antimicrobial efficacy was evaluated reduction bacterial load most common bacteria isolated from cases with endophthalmitis. Setting: 20 Italian experimental centers Effectiveness Liposomal Ozonized on Ocular Microbial flora before surgery study group. Design: Interventional, nonrandomized, paired-eye designed, phase 4 clinical study....
The aim of this in vitro study was to compare the efficacy chemical and mechanical methods for decontamination titanium dental implant surfaces previously infected with polymicrobial biofilms a model simulating peri-implant defect. Furthermore, effect each protocol on MG-63 osteoblast-like cells morphology adhesion treated implants assessed.Peri-implantitis is growing issue dentistry, evidence about surface procedures lacking inconclusive.A total 40 biofilm-contaminated were placed into...
The QuantiFERON CMV (QCMV) test evaluates specific adaptive immune system activity against by measuring IFN-γ released activated CD8+ T lymphocytes. We aimed to evaluate the QCMV as a predictive tool for manifestations and acute or chronic lung allograft rejection (AR CLAD) in transplant (LTx) patients. A total of 73 patients were divided into four groups based on donor recipient (D/R) serology assay: group low-risk infection disease (D-/R-); B C at intermediate-risk (R+), with non-reactive...
Background: The international surveillance of antimicrobial resistance (AMR) reports S. pneumoniae as one leading causes death associated with AMR. Against invasive disease, several vaccinations are available and a reduction in AMR has been observed. Here, we evaluated the impact anti-pneumococcal vaccination policy SARS-CoV2 outbreak on causing disease. Methods: We collected all strains disease from 2008 Piedmont region (Italy). Each strain was typed order to identify serogroup data about...
Abstract Background Respiratory Syncytial Virus (RSV) infection is a significant cause of bronchiolitis and pneumonia, mostly responsible for hospitalization infant death worldwide. However, in recent years the importance extrapulmonary RSV manifestations, especially at neurological level, have become evident. Seizures, lethargy, ataxia status epilepticus are suggestive brain involvement, but also their absence direct damage RSV-related need to be evaluated. Case presentation A 40-day old...
Fosfomycin is an old bactericidal drug that has gained increasing interest in the last decade for its potential use multi-drug resistant gram-negative infections. However, evidence on fosfomycin susceptibility testing reports a poor correlation between commercial methods vs. reference agar dilution (AD) Enterobacterales (EB). The study aimed at assessing performance of two automated systems determination EB clinical isolates.Fosfomycin results collections 100 non-duplicate strains obtained...
Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for development of PVAN is immunosuppression level and modulation anti-rejection treatment first line intervention. Allograft biopsy histology remain criterion standard diagnosing PVAN. Methods: All consecutive renal biopsies with diagnosis carried out at University Hospital City Health Science Turin over five-years period were studied. Renal allograft was...
Rapid identification of extended-spectrum-β-lactamase (ESBL)-, serine carbapenemase-, and metallo-β-lactamase (MBL)-producing Enterobacterales directly from positive blood culture (BC) bottles is paramount importance to early optimize antimicrobial management infection control measures. In this study, we describe evaluate an improved variant direct β-lactam inactivation method, named ethylenediaminetetraaceticacid-modified-β-lactam method (deBLIM). The deBLIM test designed detect ESBL or...
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues to spread with more than 131 million cases confirmed worldwide (as of April 6, 2021), patients treated for hematological disorders concurrent SARS-CoV-2 infection have been reported.1 Managing on active chemo-immunotherapy remains critical: severity disease 2019 (COVID-19) signs and symptoms, histotype expected prognosis, together individual patient characteristics, play a pivotal role.2 Here we describe...
Introduction: Patients with hematologic malignancies are more likely to develop severe and prolonged SARS-CoV-2 infection, often showing viral persistence despite the use of authorized antivirals. Herein, we report cases four patients who received rituximab for different conditions developed persistent COVID-19 treated an extended course dual antivirals, Nirmatrelvir/Ritonavir Remdesivir. Moreover, describe pharmacokinetics pharmacogenetics (PK/PG) characteristics Remdesivir treatment in two...