A5038753379- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chemotherapy-induced cardiotoxicity and mitigation
- Pharmaceutical studies and practices
- Chronic Myeloid Leukemia Treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Stress Responses and Cortisol
- Peripheral Neuropathies and Disorders
- Central Venous Catheters and Hemodialysis
- Pediatric Pain Management Techniques
- Blood Coagulation and Thrombosis Mechanisms
- Cancer survivorship and care
- Chronic Lymphocytic Leukemia Research
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Optimism, Hope, and Well-being
- Protein Tyrosine Phosphatases
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Cancer-related cognitive impairment studies
- Neuroendocrine regulation and behavior
- Coenzyme Q10 studies and effects
Ospedale Regina Margherita
2011-2025
University of Turin
1996-2024
Piedmont Reference Center for Epidemiology and Cancer Prevention
2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2021
Boston Children's Hospital
2012-2014
Abstract Background A 4‐week course of high‐dose glucocorticoids may cause prolonged adrenal suppression even after a 9‐day tapering phase. In this study, function and signs symptoms insufficiency were prospectively assessed in children with acute lymphoblastic leukemia (ALL) induction treatment including prednisone (PDN) or dexamethasone (DXM). Procedures Sixty‐four ALL, treated according to the AIEOP ALL 2000 Study protocol, underwent low dose ACTH (LD‐ACTH) stimulation 24 hr last tapered...
Five-year event-free survival in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) currently exceeds 80–85%. However, 15–20% of patients still experience a relapsed/refractory disease. From 1 January 2015 to 31 December 2020, thirty-nine patients, 0–21 years old with r/r BCP-ALL were treated blinatumomab the aim inducing remission (n = 13) or reducing MRD levels 26) frame different multiagent chemotherapy schedules, seven AIEOP centers. Patients compassionate and/or off-label...
High-dose methotrexate (HD-MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642), ABCC2 (rs717620), ABCC3 (rs9895420), ABCC4 (rs7317112) drug transporters genes on HD-MTX pharmacokinetics patients' outcome (meant both as relapse drug-related toxicities) an Italian cohort 204 ALL pediatric patients treated according...
Clofarabine is a promising new chemotherapeutic agent that active in the treatment of pediatric acute leukemia. Forty children (16 with myeloid leukemia [AML], 24 lymphoblastic [ALL]), aged 1-20 years (median 7.6 years) relapsed or refractory ALL AML were treated because resistance to first-line (n =5), for first =22), second =11) third relapse =2). They received clofarabine (40 mg/m(2)/day) associated etoposide (100 and cyclophosphamide (440 administered as one two induction cycles (5 days...
This study focuses on body image discomfort (BID) of 50 adolescent and young adult (AYA) hematologic cancer survivors (age range 15–23; 52% males). The results were obtained through data from a self-report questionnaire: the Body Uneasiness Test. Findings differed according to gender: greater proportion females in Risk category impaired than males (χ2 = 5.258, p < 0.05). No significant differences found type diagnosis or length survival. To manage survivors' BIDs improve their quality life,...
Abstract Cardiovascular disease is the leading cause of non‐malignant morbidity and mortality in childhood cancer survivors (CCSs). Anthracyclines are included many treatment regimens for paediatric cancer, but unfortunately, these compounds cardiotoxic. One 10 CCSs who has received an anthracycline will develop a symptomatic cardiac event over time. Given crucial need to mitigate anthracycline‐related cardiotoxicity (ARC), authors critically examined published data identify effective...
Children with acute lymphoblastic leukemia (ALL) receive as part of induction therapy a 4-week course high-dose glucocorticoid, which is either abruptly discontinued or shortly tapered. The aim this study was to evaluate the signs and symptoms steroid withdrawal syndrome performance status (according Lansky scale) during 9-day tapering period 1 week after in 63 children randomly allocated prednisone dexamethasone treatment according AIEOP ALL 2000 protocol. Twenty 28 (75%) patients on versus...
In the present study authors evaluated therapy-related long-term adverse effects and physical activity in a cohort of survivors childhood acute lymphoblastic leukemia (ALL), diagnosed their center between March 1991 August 2000, treated according to AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) ALL 91 or 95 protocol regularly seen authors' follow-up unit. The analyzed sequelae major body systems this subjects administered an "ad hoc" questionnaire concerning sport. found...
Children receiving Total Body Irradiation (TBI) in preparation for Hematopoietic Stem Cell Transplantation (HSCT) are at risk Growth Hormone Deficiency (GHD), which sometimes severely compromises their Final Height (FH). To better represent the impact of such therapies on growth we apply a mathematical model, accounts both gompertzian-like trend and hormone-related 'spurts', evaluate how parameter values estimated children undergoing TBI differ from those matched normal population. 25...
10017 Background: Bosutinib is a tyrosine kinase inhibitor (TKI), approved for adults with Philadelphia Chromosome (Ph+) CML; at the standard initial dose of 400 mg/day in ND patients, and 500 resistant/intolerant (R/I) administered orally once daily (QD) food. Compared to TKIs already pediatrics, bosutinib has different tolerability profile, preclinical data suggest that longitudinal growth potentially less impaired. Study NCT04258943 an international, open-label, phase I/II trial,...
In the maintenance phase of Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)- Berlin-Frankfurt-Muenster (BFM) acute lymphoblastic leukemia (ALL) 2009 protocol, mercaptopurine (MP) is given at planned dose 50 mg/m2 /day; however, adjustments are routinely performed to target patients' white blood cells optimal range 2,000-3,000 cells/μL. Pediatric patients with ALL (n = 290, age: median (1st-3rd quartile): 4.8 (3.0-8.1) years; boys: 56.9%) were enrolled mainly in 4...
In Europe, despite recent advances in clinical development, most of the drugs currently used to treat childhood cancers are adult medicines, prescribed outside authorized indication. this context, a monocentric retrospective cohort analysis was conducted, evaluating pediatric, adolescent, and young patients affected by onco-hematologic disease, treated with targeted therapies off-label or as compassionate use.The conducted on 45 aged less than equal 30 years cancer, having received at least...
A 12-year-old male being treated for a high-risk relapsed T-acute lymphoblastic leukemia presented progressive weakness and numbness of both legs after having received chemotherapy regimen that included bortezomib. Diagnosis acute Guillain-Barré syndrome (GBS)-like inflammatory demyelinating polyneuropathy was made following clinical examination, cerebrospinal fluid analysis, electrodiagnostic studies, magnetic resonance imaging, serum immunoglobulin antibodies to anti-ganglioside....
The survival of pediatric cancer patients has significantly increased thanks to the improvement oncological treatments. Therefore, it is utmost importance manage short- and long-term cardiovascular complications. In cardio-oncology, there are no recognized guidelines as in adults. Several recommendations many indications have been derived from data obtained adult population, resulting greater discrepancies clinical management patients. aim this position paper Italian Society Pediatric...
Experiences related to pediatric oncology diagnosis cause great imbalances within the family structure. Assessing frailties and needs of families children with cancer from a psychosocial perspective is an important step in providing appropriate psychology care.