A5101683361- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Stress, Anesthesia, and Immune Response
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Hemophilia Treatment and Research
- Genetic factors in colorectal cancer
- Cancer-related cognitive impairment studies
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Pharmacology and Obesity Treatment
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
Heidelberg University
2015-2025
University Hospital Heidelberg
2015-2025
University Medical Centre Mannheim
2018-2024
Medizinische Fakultät Mannheim
2022
Frauenklinik Heidelberg
2017-2022
Deleted Institution
2022
University of Nis
2021
Public Health Dayton & Montgomery County
2021
University of Tübingen
1998-2018
National Center for Tumor Diseases
2012-2017
Considering the diverse functions of B cells, responses to tumor-associated antigens (TAA) have been thought be main source cell-mediated antitumor immunity. Polymorphic epithelial mucin (MUC1) is considered one most specific TAA in patients with breast cancer. The present study aims dissect level and subclasses naturally occurring anti-MUC1 antibodies regard tumor biologic parameters, clinical characteristics overall survival. In 288 primary, non-metastatic cancer patients, pretreatment...
The loss of breast cancer cell differentiation during metastatic progression leads to a down-regulation class 1 human leukocyte antigen (HLA) expression, which in turn hinders cytotoxic T lymphocytes from effectively preventing tumor proliferation. Consequently, one would expect that decreased HLA expression correlate with 5-year survival. However, estrogen receptor alpha (ESR1) is known be positively associated overall study aimed determine the levels HLA-A, HLA-B/C, and ESR1 assess their...
Background/Aim: Class 1 human leukocyte antigen (HLA) ensures that cytotoxic T lymphocytes (CTLs) attack tumor cells. As part of de-differentiation, the expression HLA on cell surface may decrease, which can facilitate growth. Therefore, reduced is generally negatively associated with overall survival (OS). The reverse true for programmed death protein (PD-1) and ligand (PD-L1). presence PD-1 PD-L1 cancer cells inhibits immune defense mechanisms against one would expect increased PD-1/PDL-1...
Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive innate anti-tumor response including Human Leukocyte Antigen (HLA) machinery antigen presentation unclear. We present data on HLA class II-chaperone molecule CD74 in its impact peptidome complexity. analyzed II expression tumor cells a subset 236 human metastases, primary tumors peripheral different entities association clinical...
Detection of circulating tumor cells (CTC) can distinguish between aggressive and indolent metastatic disease in breast cancer patients is thus considered an independent, negative prognostic factor. A clear decline CTCs observed who respond to systemic therapy. Nevertheless, decrease experiencing progression during therapy, too. This study aims determine the differences CTC responding therapy those whom progressing. Therefore, values were compared at start after one cycle a new line In all,...
To compare the microscopic, macroscopic and thermal damage inflicted to ovarian tissue by conventional monopolar bipolar energy, argon plasma coagulation (APC) diode laser.Bovine ovaries were used as a substitute for human subjected four aforementioned techniques was measured. Sixty fresh morphologically similar cadaveric bovine divided into five equal groups, each group one of following energy applications both 1 5 s: Monopolar, electrocoagulation, laser, preciseAPC® forcedAPC® Ovarian...
// Stefan Stefanovic 1, 2, * , Ralph Wirtz 3, Thomas M. Deutsch 2 Andreas Hartkopf 4 Peter Sinn 5 Zsuzsanna Varga 6 Bettina Sobottka Lakis Sotiris 3 Florin-Andrei Taran Christoph Domschke Andre Hennigs Sara Y. Brucker 7 Christof Sohn Florian Schuetz Schneeweiss and Markus Wallwiener 1 Department of Gynecology Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany National Center for Tumor Diseases (NCT) Stratifyer Molecular Pathology GmbH, 50935 Cologne, Women's Health,...
Background/Aim: Loss of differentiation breast cancer cells in association with a down-regulated class I human leukocyte antigen (HLA) expression can lead to proliferation unhampered by cytotoxic T lymphocytes, which has been proven be prognostic relevance. The objective this study was determine the levels HLA-A and HLA-B/C metastatic (MBC) their usefulness for predicting 5-year survival. Materials Methods: This prospective double-blinded cohort analyzed patients starting new line therapy...
The presence of circulating tumor cells (CTCs), detected as a form liquid biopsy is associated with poor survival in both early and metastatic breast cancer. Monitoring biology based on intrinsic subtypes delivers treatment-relevant information the heterogeneity or biomarker conversion between primary tumors. This study aimed to correlate change apoptotic intact CTC counts mRNA-assessed subtype change. Thirty-four cancer patients available triplets tumors, distant metastasis biopsies data...
Previous studies have shown that self-antigens overexpressed in malignant tissue can provide a basis for tumor-specific immune response. The mucin MUC2 is strongly all mucinous tumors of colon, breast, ovary and pancreas. In the corresponding normal it either not expressed (breast, ovary, pancreas) or at considerably lower levels than (colon). We therefore investigated whether molecule comprises HLA-A2-binding epitopes recognized by human cytotoxic T cells. Four peptides with high affinity...
Patients with metastasized breast cancer often suffer from discomfort caused by metastatic bone disease. Thus, osteoprotection is an important part of therapy in to bone, and bisphosphonates (BPs) are a major therapeutic option. In this study, our objectives were compare the side effects oral versus intravenous BP treatment assess their clinical effectiveness.In prospective randomized, open-label, non-inferiority trial, we enrolled patients at least one metastasis Eastern Cooperative...
The objective of this study was to assess the perception forensic medical examination (FME) by victims sexual violence. Based on patient-related outcomes gained in terms personnel, chronological and spatial parameters, an additional aim derive improved procedures.A total 49 sexually assaulted women were enrolled study. After standardized FME a doctor followed gynecologist, asked complete questionnaire addressing general perception, preferences regarding attending staff's sex, sequence time...
Circulating tumor cell (CTC) detection is a prognostic factor in the metastatic breast cancer (MBC) setting. Discrepancies primary (PT) and (MT) genetic profiles are also of importance. Our study aimed to compare CTC statuses prognoses between those with subtype stable MBCs specific biomarker conversions. The enrolled 261 MBC patients, treated at National Center for Tumor Diseases, Heidelberg, Germany five-year period. All underwent PT MT biopsies subsequent enumeration before initiation...
Abstract Background: In recent years, the treatment of breast cancer has taken path towards personalized medicine. Based on individual tumor biology, therapy tailored to particular subtype is increasingly being used. The aim find most suitable for disease. However, success depends a large extent patient's adherence treatment. This, in turn, how tolerated and team cares patient. Patient-centered care seeks identify address needs each patient best form that person. Objectives: order improve...
Abstract Background: The genotype and phenotype of breast cancer may change during disease progression. This is particular interest in the advent targeted treatment adressing extracellular targets such as TROP2, which serves chemotherapy carrier rather than being required for tumor cell survival. In addition, technical issues affect biomarker assessment when comparing primary (PBC) tissues with biopsies metastatic (MBC) at distant sites. Here we analyzed TROP2 expression on mRNA level by...