A5005228994- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Cancer Immunotherapy and Biomarkers
- Digital Radiography and Breast Imaging
- Pelvic floor disorders treatments
- Cancer survivorship and care
- AI in cancer detection
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Pregnancy and preeclampsia studies
- Inflammatory Biomarkers in Disease Prognosis
- Urinary Bladder and Prostate Research
University Hospital Heidelberg
2015-2024
Heidelberg University
2015-2024
National Center for Tumor Diseases
2015-2021
Frauenklinik Heidelberg
2014-2020
German Cancer Research Center
2019-2020
Universitäts Frauenklinik
2016-2020
Ludwig-Maximilians-Universität München
2019
University of Oslo
2019
University Medical Center Hamburg-Eppendorf
2019
Oslo University Hospital
2019
Abstract Purpose Breast cancer (BC) is the most common malignancy among women and prognosis strongly influenced by tumor subtype. Neoadjuvant chemotherapy (NAC) standard treatment for both locally advanced- early-stage triple-negative Her2-positive BC. Pathologic complete response (pCR) to NAC an important predictor of patient outcomes. Neutrophil-to-lymphocyte-ratio (NLR) in peripheral blood associated with various malignancies. Here, we investigated value pretreatment NLR as a...
Breast cancer is the leading cause of cancer-related mortality among women in Germany and worldwide. This retrospective claims data analysis utilizing from AOK Baden-Wuerttemberg, a major statutory German health insurance provider, aimed to construct assess real-world breast disease model. The study included 27,869 female patients 55,738 age-matched controls, analyzing 2010 2020. Three distinct stages were analyzed: Stage A (early without lymph node involvement), B with C (primary distant...
Abstract Objective The FUSION-X-US-II prototype was developed to combine 3D automated breast ultrasound (ABUS) and digital tomosynthesis in a single device. We evaluated the performance of ABUS examination clinical setting. Methods In this prospective feasibility study, were performed using without any change position patients referred for clarification lesions with an indication tomosynthesis. images interpreted independently from standard by diagnostics specialist. Any detected lesion...
COGNITION (Comprehensive assessment of clinical features, genomics and further molecular markers to identify patients with early breast cancer for enrolment on marker driven trials) is a diagnostic registry trial that employs genomic transcriptomic profiling biomarkers in high risk relapse after standard neoadjuvant chemotherapy (NACT) guide genomics-driven targeted post-neoadjuvant therapy.At National Center Tumor Diseases Heidelberg were biopsied before starting NACT, residual tumors NACT...
Breast cancer may negatively affect later pregnancy and childbirth. We aimed to analyze the impact of previous breast on obstetric outcomes in postdiagnosis pregnancies.
Abstract Purpose To elucidate the association between arterial and venous Doppler ultrasound parameters risk of secondary cesarean delivery for intrapartum fetal compromise (IFC) neonatal acidosis in small-for-gestational-age (SGA) fetuses. Methods This single-center, prospective, blinded, cohort study included singleton pregnancies with an estimated weight (EFW) < 10th centile above 36 gestational weeks. Upon inclusion, all women underwent ultrasound, including umbilical artery (UA)...
The aim of this study was to evaluate in detail the histopathological characteristics endarterectomized carotid atherosclerotic lesions symptomatic versus asymptomatic patients. Twenty lesions, 10 from and patients who underwent endarterectomy were classified according histomorphological features. Samples analyzed for intraplaque localization expression proteins associated with inflammation, such as CD68, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), pentraxin-3 (PTX-3), nuclear...
Patients with metastasized breast cancer often suffer from discomfort caused by metastatic bone disease. Thus, osteoprotection is an important part of therapy in to bone, and bisphosphonates (BPs) are a major therapeutic option. In this study, our objectives were compare the side effects oral versus intravenous BP treatment assess their clinical effectiveness.In prospective randomized, open-label, non-inferiority trial, we enrolled patients at least one metastasis Eastern Cooperative...
Abstract Introduction As early breast cancer might relapse even after complete removal of and lymphnodes, the disease must persist in secondary sites. The detection disseminated tumor cells (DTC) bone marrow (BM) has been described as a surrogate residual disease. Various trials showed an impaired prognosis DTC positive (EBC) patients. PADDY (Pooled Analysis Detection Early Breast Cancer) study is large international pooled analysis that aimed to assess prognostic impact patients with EBC....
Locoregional recurrence after neoadjuvant chemotherapy for primary breast cancer is associated with poor prognosis. It essential to identify patients at high risk of locoregional who may benefit from extended local therapy. Here, we examined the prediction accuracy and clinical applicability MD Anderson Prognostic Index (MDAPI).Prospective data 456 treated between 2003 2011 was analyzed. The Kaplan-Meier method used examine probabilities recurrence, distant metastases according individual...
551 Background: In hormone-receptor positive (HR+) early breast cancer (EBC) adjuvant endocrine therapy (ET) significantly reduces recurrence and mortality. The most common way to estimate adherence is the use of patient reported outcome measures. Yet, this method inaccurate due social-desirability bias. We therefore aimed analyze ET over first 5 years treatment by using claims data from a large German health insurance provider (AOK Baden-Wuerttemberg). Methods: Female patients diagnosed...
Abstract Purpose In the ACOSOG Z0011 trial, completing axillary lymph node dissection (cALND) did not benefit patients with T1–T2 cN0 early breast cancer and 1–2 positive sentinel nodes (SLN) undergoing breast-conserving surgery (BCT). This paper reports cALND rates in clinical routine for who had higher (T3–T4) tumor stages and/or underwent mastectomy but otherwise met eligibility criteria. Aim of this study is to determine time trends non-sentinel metastases (NSAM) estimate occult burden....
Abstract Introduction and hypothesis Urinary incontinence (UI) has a potentially devastating effect on women’s quality of life (QoL). Conservative treatment by means pelvic floor muscle training is the first-choice modality. Nowadays, this can be supported digital apps like pelvina©—a health companion course. Methods Using pelvina©, UI symptoms QoL are regularly examined through questionnaires QUID SF-6D. Subsequently, we analyzed incidence degree its impact in 293 users real-world...
Background/Objectives: With breast cancer (BC) survival improving due to optimized therapy, enhancing quality of life has become increasingly important. Both diagnosis and treatment, with their potential side effects, pose risks mental well-being. Our study aimed analyze the incidence risk factors for disorders in BC patients. Methods: This retrospective analysis used claims data from AOK Baden-Wuerttemberg, including 11,553 patients diagnosed via ICD code C50 between 2010 2020 31,944...
Zielsetzung: Präeklampsie geht mit relevanten mütterlichen und fetalen Komplikationen einher. Die frühzeitige Identifizierung der Hochrisiko-Patientinnen anhand laborchemischer Marker ist im aktuellen klinischen Alltag nicht etabliert. Pathophysiologisch scheinen die systemischen mitunter durch endotheliale Dysfunktion vermittelt zu werden. Der Endothelial Activation and Stress Index (EASIX) beschreibt das Verhältnis LDH * Kreatinin / Thrombozyten gilt als für Dysfunktion. In dieser Studie...