A5000142901- Digital Radiography and Breast Imaging
- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- AI in cancer detection
- Ultrasound Imaging and Elastography
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Ultrasonics and Acoustic Wave Propagation
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- X-ray Spectroscopy and Fluorescence Analysis
- Global Cancer Incidence and Screening
- Electrical and Bioimpedance Tomography
- Medical Imaging and Pathology Studies
- Nuclear Physics and Applications
- Gene expression and cancer classification
- Calibration and Measurement Techniques
- Advanced Biosensing Techniques and Applications
- Parathyroid Disorders and Treatments
Siemens Healthcare (Germany)
2014-2024
Siemens (Germany)
2021-2023
Ludwig-Maximilians-Universität München
2018
University of Rostock
2018
LMU Klinikum
2018
University of Wisconsin System
2018
WinnMed
2018
Swedish Medical Center
2018
American Association of Physicists in Medicine
2018
Medical Research Associates
2018
We show that a distribution of micrometer-sized calcifications in the human breast which are not visible clinical x-ray mammography at diagnostic dose levels can produce significant dark-field signal grating-based phase-contrast imaging setup with tungsten anode tube operated 40 kVp. A specimen invasive ductal carcinoma was investigated immediately after surgery by Talbot-Lau interferometry design energy 25 keV. The sample contained two tumors were ultrasound and contrast-agent enhanced MRI...
Mastectomy specimens were investigated using a Talbot-Lau X-ray imaging set-up. Significant structures in the darkfield observed, which revealed considerably higher contrast than those observed digital mammography. Comparison with histomorphometric image proofs that signal correlates tumor region containing small calcification grains of 3 to 30μm size.
Purpose Talbot–Lau x‐ray interferometry provides information about the scattering and refractive properties of an object — in addition to object's attenuation features. Until recently, this method was ineligible for imaging human‐sized objects as it is challenging adapt interferometers ( TLI s) relevant energy ranges. In work, we present a preclinical prototype capable with proper image quality at clinically acceptable dose levels. Methods The designed match setup clinical relevance closely...
Besides the well-known conventional X-ray attenuation image, Talbot-Lau imaging (TLXI) provides additional information about small-angle scattering and refractive features of an object. In general, TLXI setups have to be mechanically robust, since already slight inaccuracies during measurement process result in moire artefacts. This work derives artefacts as a phase-stepping inaccuracies. The dependency these on is mathematically derived by Taylor series expansion verified simulation. Among...
X-ray dark-field imaging is a promising technique for lung diagnosis. Due to the alveolar structure of tissue, higher contrast obtained by image compared attenuation image. Animal studies indicate an enhancement regarding detection diseases in early stages. In this publication, we focus on influence different Talbot-Lau interferometer specifications while maintaining x-ray source, sample magnification and detector system. By same porcine with three grating sets, analyze contrast-to-noise...
Coherent plane-wave compound imaging (CPWCI) is used as alternative for conventional focused (CFI) to increase frame rates linearly with the ratio number of lines steering angles. In this study, image quality was compared between CPWCI and CFI, effect angles (range number) beamforming strategies evaluated in CPWCI. automated breast volume scanners (ABVSs), which suffer from reduced rates, might be an excellent candidate replace CFI. Therefore, CFI currently ABVS also <italic...
Abstract Objective The FUSION-X-US-II prototype was developed to combine 3D automated breast ultrasound (ABUS) and digital tomosynthesis in a single device. We evaluated the performance of ABUS examination clinical setting. Methods In this prospective feasibility study, were performed using without any change position patients referred for clarification lesions with an indication tomosynthesis. images interpreted independently from standard by diagnostics specialist. Any detected lesion...
Background Combinations *Equal contributors. of different imaging techniques in fusion devices appear to be associated with improvements diagnostic assessment. Purpose The aim this study was test the feasibility using an automated standard three-dimensional (3D) ultrasound (US) device fused mammography for first time breast cancer patients. Material and Methods Digital mammograms 3D US images were obtained 23 patients highly suspicious lesions. A recently developed machine consisting ABVS...
Digital breast tomosynthesis (DBT) enables significantly higher cancer detection rates compared to full-field digital mammography (FFDM) without compromising the recall rate. However, regarding microcalcification assessment established system concepts still tend be inferior FFDM. To further boost clinical role of DBT in screening and diagnosis, a concept was developed that fast wide-angle with unique in-plane resolution capabilities known from The comprises novel x-ray tube incorporates an...
The combination of different imaging modalities through the use fusion devices promises significant diagnostic improvement for breast pathology. aim this study was to evaluate image quality and clinical feasibility a prototype device (fusion prototype) constructed from standard tomosynthesis mammography unit 3D ultrasound probe using new method compression.Imaging performed on 5 mastectomy specimens patients with confirmed DCIS or invasive carcinoma (BI-RADS ™ 6). For preclinical an ABVS...
Talbot-Lau x-ray imaging (TLXI) is an innovative and promising technique providing information about the attenuation, scattering, refraction features of objects. However, method susceptible to vibrations system component imprecisions, which are inevitable in clinical industrial practice. Those influences provoke grating displacements hence errors acquired raw data, cause moiré artifacts reconstructed images. We developed enhanced reconstruction algorithm capable compensating these by...
Background: Mammography can identify calcifications up to 50–100 μm in size as a surrogate parameter for breast cancer or ductal carcinoma situ (DCIS). Microcalcifications measuring <50 µm are also associated with DCIS and frequently not detected on mammography, although they be dark-field imaging. This study examined whether additional examination using X-ray imaging increase the detection rate of calcifications. Advances knowledge: (1) evaluation modality imaging; (2) specific...
Purpose The aim of this study was to investigate whether the detection foreign bodies can be improved using dark-field and phase-contrast radiography compared with conventional (transmission) radiographs. Materials Methods Experiments were performed ex vivo pig paws, which prepared differently sized metal, wood, glass (n = 10 each). Paws without served as controls 30). All images acquired an experimental grating-based large object system. Five blinded readers (second- fourth-year radiology...
Purpose: Mammography is a widely used tool for the screening of breast cancer, and calcifications are common finding in most mammograms. The location, size, number, morphology, distribution an important information to differentiate benign lesion from probably malignant pathologies. Calcifications not detectable with standard dynamic contrast enhanced MRI. authors present novel method detection imaging tissue without ionizing radiation or agents. Methods: Measurements localized displacement...
Objective. In mammography, breast compression forms an essential part of the examination and is achieved by lowering a paddle on breast. Compression force mainly used as parameter to estimate degree compression. As does not consider variations size or tissue composition, over- undercompression are frequent result. This causes highly varying perception discomfort even pain in case overcompression during procedure. To develop holistic, patient specific workflow, first step, needs be thoroughly...
Talbot–Lau x-ray imaging provides additionally to the conventional attenuation image, two further images: differential phase-contrast image which is especially sensitive differences in refractive properties and dark-field showing scattering of object. Thus, sub-pixeled object information can be observed. As it has been shown recent studies, this special interest for lung imaging. Changes alveoli structure, are size one detector pixel, seen images. A fast acquisition process crucial avoid...
PurposeDigital breast tomosynthesis (DBT) has been introduced more than a decade ago. Studies have shown higher cancer detection rates and lower recall rates, it become an established imaging method in diagnostic settings. However, full-field digital mammography (FFDM) remains the most common modality for screening many countries, as delivers high-resolution planar images of breast. To combine advantages DBT with faster acquisition unique in-plane resolution capabilities known from FFDM,...
Talbot-Lau X-ray imaging (TLXI) provides information about scattering and refractive features of objects – in addition to the well-known conventional attenuation image. We investigated potential TLXI for detection hairline fractures bones, which are often initially occult 2D images. For this purpose, were extrinsically provoked a porcine trotter (post-mortem) scanned with system. In examined case, caused dark-field differential-phase signals, whereas they not evident These findings motivate...
Talbot-Lau X-ray imaging provides information about scattering, refraction, and attenuation features of objects. This capability offers a variety possibilities for medical industrial applications. However, already slight inaccuracies during the measurement process result in moiré artefacts reconstructed images. A sufficient setup stability is expensive not invariably achievable. We developed an advanced reconstruction algorithm, which reduces by compensating these inaccuracies. Therefore, we...
In breast cancer screening, x-ray mammography is the standard imaging modality. For clarification of suspicious findings, handheld ultrasound (US) used as an adjunct It so far not included in screening due to lack standardization, high costs and risk increased false positives within population. First attempts standardize US with automated are still completely fulfilling clinical needs, e.g. workflow reading claimed be fast enough. Therefore, various groups introduced new concepts providing...