A5067613853- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Cancer Treatment Studies
- Genetic Associations and Epidemiology
- Breast Lesions and Carcinomas
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Cancer-related gene regulation
- Migration, Health and Trauma
- Genetic Mapping and Diversity in Plants and Animals
- Protein Kinase Regulation and GTPase Signaling
- Hepatitis B Virus Studies
- Advanced Manufacturing and Logistics Optimization
- Genetics and Plant Breeding
- Sepsis Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Drug Transport and Resistance Mechanisms
- Vehicle Routing Optimization Methods
- Cancer Mechanisms and Therapy
- Neuroscience and Neuropharmacology Research
- PI3K/AKT/mTOR signaling in cancer
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- BRCA gene mutations in cancer
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
Heidelberg University
2016-2022
Zimmer Biomet (Germany)
2016-2022
University Hospital Heidelberg
2019
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2016
Universidad de Valladolid
2010
The University of Texas Southwestern Medical Center
2010
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration specific associations with common diseases may lead to substantial advances in unraveling disease etiology and prevention. Here we investigate possible between ancestry leading causes death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans 639,789 deaths, validate identified association gallbladder cancer relying individual 64 patients, without a...
Abstract Gallbladder carcinoma (GBC) is a biliary tract cancer with few treatment options and poor prognosis. Radical surgery the only potentially curative option but most patients diagnosed GBC are unresectable. Thus, there great need for development of new including targeted therapy. Here, we aimed at identifying deregulated miRNAs affected pathways involved in progression. We performed global miRNA profiling 40 8 normal gallbladder tissues identified large differences 30% being...
Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified 233 TNBC case–control pairs (discovery set) and subsequently validated independent validation set (57 patients 124 controls). Results: cg06588802 (LINC00299/ID2) showed a higher compared with controls set: 3% increase, p-value = 0.0009; 2% 0.01)....
Latino women show lower incidences of breast cancer (BC) than non-Hispanic whites. Large-scale genetic association studies have identified variants robustly associated with BC risk in European women. We examine here the relevance these to Colombian and possible interactions ancestry. Native American, African proportions were estimated for 1022 cases 1023 controls. Logistic regression was applied assess between 78 ancestry proportions. constructed a multifactorial score combining established...
The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 ABCB4 genes for individuals Indian descent. We investigated whether these were also associated with GBC risk Chileans, who show highest incidence worldwide, Europeans a low incidence. This population-based analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) prospective European cohort (108 181...
Cancer cell lines allow the identification of clinically relevant alterations and prediction drug response. However, sequencing data for hepatobiliary cancer in general, particularly gallbladder (GBC), are sparse. Here, we apply RNA to characterize 10 GBC, eight hepatocellular carcinoma, five cholangiocarcinoma (CCA) lines. extraction, quality control, library preparation, sequencing, pre-processing were implemented using state-of-the-art techniques. Public from MSK-IMPACT database a large...
Locoregional recurrence after neoadjuvant chemotherapy for primary breast cancer is associated with poor prognosis. It essential to identify patients at high risk of locoregional who may benefit from extended local therapy. Here, we examined the prediction accuracy and clinical applicability MD Anderson Prognostic Index (MDAPI).Prospective data 456 treated between 2003 2011 was analyzed. The Kaplan-Meier method used examine probabilities recurrence, distant metastases according individual...
The relationship between genetic variability and individual phenotypes is usually investigated by testing for association relying on called genotypes. Allele counts obtained from next-generation sequence data could be used this purpose too. Genetic can examined treating alternative allele (AACs) as the response variable in negative binomial regression. AACs often contain an excess of zeros, thus motivating use Hurdle zero-inflated models. Here we examine rough type I error rates ability to...
RNA sequence data are commonly summarized as read counts. By contrast, so far there is no alternative to genotype calling for investigating the relationship between genetic variants determined by next-generation sequencing (NGS) and a phenotype of interest. Here we propose evaluate direct analysis allele counts association tests. Specifically, assess potential advantage ratio total number reads aligned at specific position genome (coverage) over called genotypes. We simulated studies based...
Zielsetzung: Validierung des MD Anderson Prognostic Index (MDAPI) zur lokoregionären Risikokalkulation nach neoadjuvanter Therapie.
Locoregional control is an important goal in breast cancer therapy but the prediction of locoregional recurrence to guide local after neoadjuvant chemotherapy remains a challenge. The CPS+EG score was designed predict distant recurrence. Here we examine its ability both – and