A5076705834- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- vaccines and immunoinformatics approaches
- Privacy-Preserving Technologies in Data
- SARS-CoV-2 and COVID-19 Research
- Machine Learning in Bioinformatics
- Gene expression and cancer classification
- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Mass Spectrometry Techniques and Applications
- T-cell and B-cell Immunology
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- Cryptography and Data Security
- Radiomics and Machine Learning in Medical Imaging
- Machine Learning in Healthcare
University of Tübingen
2010-2025
German Center for Infection Research
2019-2024
Bernstein Center for Computational Neuroscience Tübingen
2021-2024
Max Planck Institute for Informatics
2014-2023
Institute of Virology of the Slovak Academy of Sciences
2021
University of Cologne
2021
University Hospital Cologne
2021
Bernhard Nocht Institute for Tropical Medicine
2021
University Medical Center Hamburg-Eppendorf
2021
Universität Hamburg
2021
Mass spectrometry is an essential analytical technique for high-throughput analysis in proteomics and metabolomics. The development of new separation techniques, precise mass analyzers experimental protocols a very active field research. This leads to more complex setups yielding ever increasing amounts data. Consequently, the data currently often bottleneck studies. Although software tools many tasks are available today, they hard combine with each other or not flexible enough allow rapid...
The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs vaccines are limited or not available, new options COVID-19 treatment prevention in high demand. To identify SARS-CoV-2-neutralizing antibodies, we analyzed antibody response of 12 patients from 8 to 69 days after diagnosis. By screening 4,313 SARS-CoV-2-reactive B cells, isolated 255 antibodies different time points as early Of these, 27 potently neutralized...
3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on viral envelope spike. When administered passively, this can prevent infection in animal models suppress viremia HIV-1-infected individuals. Here we report immunotherapy with single injection of affects host responses viremic In comparison untreated controls showed little change their activity over 6-month period, infusion significantly improved heterologous tier 2 viruses nearly all study...
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data 1071 individuals, we ran >3000 genome-wide scans, testing for associations between DNA polymorphisms, variation plasma load (VL), while considering population structure. We observed significant SNP to a total of 48 amino acid variants (p<2.4 × 10(-12)). All associated SNPs mapped the HLA class I region. Clinical relevance pathogen was assessed using VL results....
Investigating outcomes of hospitalised COVID-19 patients throughout the pandemic is crucial to understand impact different SARS-CoV-2 variants. We compared 28-day in-hospital mortality Wild-type, Alpha, Delta, and Omicron variant infections. Whether difference in risk by varied age was also evaluated. conducted a cohort study including ≥18 years, between 2020 02-01 2022-10-15 with positive test, from nine countries. Variant classified based on sequenced viruses or national public metadata....
Abstract Motivation: Experimental techniques in proteomics have seen rapid development over the last few years. Volume and complexity of data both been growing at a similar rate. Accordingly, management analysis are one major challenges proteomics. Flexible algorithms required to handle changing experimental setups assist developing validating new methods. In order facilitate these studies, it would be desirable flexible ‘toolbox’ versatile user-friendly applications allowing for...
Despite ongoing cancer research, available therapies are still limited in quantity and effectiveness, making treatment decisions for individual patients remains a hard problem. Established subtypes, which help guide these decisions, mainly based on data types. However, the analysis of multidimensional patient involving measurements various molecular features could reveal intrinsic characteristics tumor. Large-scale projects accumulate this kind types, but we lack computational methods to...
ABSTRACT The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes (CTL) restricted with or identical binding motifs are known to target at different frequencies, functional avidities and apparent clinical outcomes. Such differences may be illuminated the association distinctive escape pathways. Using novel computational method featuring phylogenetically corrected odds...
ABSTRACT HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other properties offers a unique perspective from which to identify correlates protective cellular immunity. We analyzed HLA-associated HIV-1 subtype B in 1,888 treatment-naïve, chronically infected individuals using phylogenetically informed...
The identification and isolation of highly infectious SARS-CoV-2-infected individuals is an important public health strategy. Rapid antigen detection tests (RADT) are promising tools for large-scale screenings due to timely results feasibility on-site testing. Nonetheless, the diagnostic performance RADT in detecting not yet fully determined. In this study, RT-qPCR virus culture RT-qPCR-positive samples were used evaluate compare Standard Q COVID-19 Ag test possibly individuals. To end, two...
High-throughput peptide and protein identification technologies have benefited tremendously from strategies based on tandem mass spectrometry (MS/MS) in combination with database searching algorithms. A major problem existing methods lies within the significant number of false positive negative annotations. So far, standard algorithms for do not use information gained separation processes usually involved analysis, such as retention time information, which are readily available...
To study the diversity of immune receptors and pathogens, multiplex PCR has become a central approach in research diagnostics. However, insufficient primer design against highly diverse templates often prevents amplification therefore limits correct understanding biological processes. Here, we present openPrimeR, an R-based tool for evaluating designing primers. openPrimeR provides functional intuitive interface uses either greedy algorithm or integer linear program to compute minimal set...