A5009104393- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Neurological disorders and treatments
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Ubiquitin and proteasome pathways
- SARS-CoV-2 detection and testing
- Immunodeficiency and Autoimmune Disorders
- Antibiotics Pharmacokinetics and Efficacy
- CAR-T cell therapy research
- Epilepsy research and treatment
- Histone Deacetylase Inhibitors Research
- Polyomavirus and related diseases
- Phagocytosis and Immune Regulation
- Peptidase Inhibition and Analysis
- Probiotics and Fermented Foods
- Immunotherapy and Immune Responses
- Potassium and Related Disorders
- T-cell and Retrovirus Studies
University of Cologne
2013-2023
Düsseldorf University Hospital
2022-2023
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2013-2023
University Hospital Cologne
2016-2023
Heinrich Heine University Düsseldorf
2022-2023
Institute of Virology of the Slovak Academy of Sciences
2021
Integrated Oncology (United States)
2020
University of Tübingen
1998-2012
Hertie Institute for Clinical Brain Research
2004-2007
St. Elizabeth Hospital in Enumclaw
2007
Abstract Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand mechanisms that lead treatment resistance. To this end, we analyzed whole-exome sequencing data eight chronic lymphocytic leukemia (CLL) patients developed resistance upon BCL2-inhibition by venetoclax. Here, report recurrent mutations in BTG1 (2 patients) and homozygous deletions affecting CDKN2A/B (3 during treatment, as well mutation BRAF high-level focal amplification CD274 (...
Abstract T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), nucleotide sequences 111 well-characterized patients. Besides prominent signatures activation prevalent clonal variants, also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, progression-associated dynamics. The overall lesional spectrum T-PLL mainly...
The recent identification of fragile X-associated tremor ataxia syndrome (FXTAS) associated with premutations in the FMR1 gene and possibility clinical overlap multiple system atrophy (MSA) has raised important questions, such as whether genetic testing for FXTAS should be performed routinely MSA positive cases might affect specificity current diagnostic criteria. We genotyped 507 patients clinically diagnosed or pathologically proven repeat length. Among 426 cases, we identified four...
Abstract In our study, a novel, fully human, recombinant monoclonal antibody of the IgG1 isotype, called MT201, was characterized for its binding properties, complement‐dependent (CDC) and antibody‐dependent cellular cytotoxicity (ADCC), as well in vivo antitumor activity nude mouse model. MT201 found to bind target, epithelial cell adhesion molecule (Ep‐CAM; also 17‐1A antigen, KSA, EGP‐2, GA733‐2), with low affinity range similar that clinically validated, murine IgG2a edrecolomab...
In chronic lymphocytic leukemia (CLL), epigenetic alterations are considered to centrally shape the transcriptional signatures that drive disease evolution and underlie its biological clinical subsets. Characterizations of regulators, particularly histone-modifying enzymes, very rudimentary in CLL. efforts establish effectors CLL-associated oncogene T-cell 1A (TCL1A), we identified here lysine-specific histone demethylase KDM1A interact with TCL1A protein B-cells conjunction an increased...
IL-8 is an important mediator of leukocyte trafficking and activation, participating in tumor angiogenesis, inflammatory processes coronary atherosclerosis. Under flow conditions IL-8, conjunction with MCP-1, triggers the firm adhesion monocytes to vascular endothelium. While previous studies have suggested requirement NF-κB for secretion by endothelial cells, we investigated possibility transactivation under suppression. Inhibition proteasome MG-132 or lactacystin completely blocked...
Recently, association of a <i>TOR1A(DYT1)/TOR1B</i> risk haplotype with common forms idiopathic dystonia has been reported in the Icelandic population. Here we report strong two single nucleotide polymorphisms within or close proximity to <i>TOR1A</i> 3′UTR, lowest <i>p</i> value being 0.000008, larger cohort German and Austrian patients predominantly focal sporadic dystonia.
Redox stress is a hallmark of the rewired metabolic phenotype cancer. The underlying dysregulation reactive oxygen species (ROS) interconnected with abnormal mitochondrial biogenesis and function. In chronic lymphocytic leukemia (CLL), elevated ROS are implicated in clonal outgrowth drug resistance. pro-survival oncogene T-cell 1 (TCL1) causally linked to high threshold towards classical apoptosis CLL. We investigated how aberrant redox characteristics bioenergetics CLL impacted by TCL1 if...
The purpose of this study was to evaluate the pharmacokinetics etanercept in patients with ankylosing spondylitis (AS) a phase 3 study.Serum concentrations were analyzed from samples obtained at weeks 4 and 12 43 AS (median age: 45 years; median body weight: 75 kg; white/non-white: 40/3; male/female: 34/9) receiving 25 mg subcutaneously twice weekly for weeks. A population analysis using NONMEM conducted estimate individual pharmacokinetic parameters. Initially, appropriate base covariate...
Natali Pfluga*, Paula Cramera, Sandra Robrechta, Jasmin Bahloa, Anne Westermanna, Anna-Maria Finka, Alexandra Schradera, Petra Mayera, Sebastian Oberbecka, Till Seilerb, Thorsten Zenzc, Jan Dürigd, Karl-Anton Kreuzera, Stephan Stilgenbauere, Barbara Eichhorsta, Michael Halleka**, Marco Herlinga* & Georg Hopfingerf*a Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, Deutsche CLL Studiengruppe (DCLLSG), Excellence Cluster Cellular Stress Response and Aging-Associated...
Controversy exists about the net effect of alcohol on atherogenesis. A protective is assumed, especially from tannins and phenolic compounds in red wine, owing to their inhibition low density lipoprotein (LDL) oxidation. However, increased atherogenesis occurs subjects with moderate heavy drinking habits. The purpose this study was investigate influence combination oxysterols endothelium. Cultured human arterial endothelial cells (HAECs) served as an vitro model test cellular effects various...
Gentamicin, tobramycin, and netilmicin were given to rats in daily doses of either 5 or 20 mg/kg for 30 days determine the renal accumulation kinetics compounds correlate steady-state parenchymal concentrations with nephrotoxicity. Four from each group sacrificed tissue determined microbiologically. Nephrotoxicity was assessed by changes creatinine values serum, clearances, pathological scores. There no indication aminoglycoside-induced nephrotoxicity any tests performed. The following...
Abstract To date, there are few reports of paroxysmal exercise‐induced dystonia associated with familial epilepsy. We describe a family 4 affected members spanning 3 generations, suggestive autosomal‐dominant inheritance, who exhibited typical dystonia, different types epilepsy (absence and primary generalized seizures), developmental delay, migraine in variable combinations. Linkage the disease to loci on chromosome 2 (paroxysmal nonkinesigenic dyskinesia) 16 kinesigenic choreoathetosis,...
The enterotoxin from cell-free filtrates of the enteropathogenic Escherichia coli strain P-263 was found to stimulate adenylate cyclase activity in broken-cell preparations myocardial tissue. Particulate and detergent-solubilized fractions cat heart were incubated with assayed for activity. Adenylate stimulated by enterotoxin; extent stimulation proportional concentration enterotoxin. data demonstrate that enterotoxin-sensitive this system provides a sensitive vitro assay, either as an...
Upregulation of the proto-oncogene T-cell leukemia/lymphoma 1A (TCL1A) is causally implicated in various B-cell and malignancies. High-level TCL1A correlates with aggressive disease features inferior clinical outcomes. However, molecular cell biological consequences of, particularly nuclear, are not fully elucidated. We observed here mouse models subcellular site-specific TCL1A-induced lymphomagenesis that exerts a strong transforming impact via nuclear topography. In proteomic screens...