A5066313683- Extracellular vesicles in disease
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Protist diversity and phylogeny
- Cancer, Lipids, and Metabolism
- Proteins in Food Systems
- Bacterial biofilms and quorum sensing
- Inorganic Fluorides and Related Compounds
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
Fraunhofer Institute for Microengineering and Microsystems
2024
Carl Zeiss (Germany)
2024
Helmholtz Institute for Pharmaceutical Research Saarland
2021-2023
Helmholtz Centre for Infection Research
2021-2023
Saarland University
1971-2023
Abstract Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug delivery vehicles. However, EVs usually stored at −80 °C which limits potential clinical applicability. Freeze‐drying of striving for long‐term stable formulations is therefore studied. The most appropriate formulation parameters identified in freeze‐thawing studies with two different EV types. After a freeze‐drying feasibility study, four lyophilized tested storage stability up to 6 months....
Abstract Recently, extracellular vesicles (EVs) sparked substantial therapeutic interest, particularly due to their ability mediate targeted transport between tissues and cells. Yet, EVs’ technological translation as therapeutics strongly depends on better biocompatibility assessments in more complex models elementary vitro–in vivo correlation, comparison of mammalian versus bacterial vesicles. With this mind, two new types EVs derived from human B‐lymphoid cells with low immunogenicity...
Theranostic systems enable early cancer diagnostic and treatment. In this work, we prepared Na-caseinate coated magnetic nanoparticles (MNP) to assess their capability as a theranostic system. This system enables monitoring by particle imaging (MPI), drug delivery hyperthermia. MNP were synthesized in continuous flow, with enzymatically crosslinked transglutaminase increase colloidal stability loading. They investigated concerning behaviour DC magnetization measurements (DCM), spectroscopy...
Outer membrane vesicles are small, lipid-based shed from the outer of Gram-negative bacteria.
Abstract Mittels Tieftemperatur‐Differentialthermoanalyse wurde das Schmelzpunktsdiagramm eines Gemisches aus trimerem cis‐ und trans‐Sulfanurfluorid (Smp. 17,1 bzw. −13,5°C) ermittelt. Die beiden Verbindungen bilden ein einfaches eutektisches Gemisch −32,5°C) ohne erkennbare Randlöslichkeit. angewandte experimentelle Technik wird eingehend beschrieben.