A5032075369- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Dysphagia Assessment and Management
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Reproductive System and Pregnancy
- Nutrition and Health in Aging
- Sperm and Testicular Function
- Gut microbiota and health
- Circular RNAs in diseases
Saarland University
2018-2023
Abstract Small non-coding RNAs (sncRNAs) are pervasive regulators of physiological and pathological processes. We previously developed the human miRNA Tissue Atlas, detailing expression miRNAs across organs in body. Here, we present an updated resource containing sequencing data 188 tissue samples comprising 21 organ types retrieved from six humans. Sampling same bodies minimizes intra-individual variability facilitates making a precise high-resolution body map transcriptome. The allow...
Abstract The composition of the gut microbiota is linked to multiple diseases, including Parkinson’s disease (PD). Abundance bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions humans. In interventional, monocentric, open-label clinical trial “Effects Resistant Starch on Bowel Habits, Short Chain Fatty Acids Gut Microbiota Parkinson ’s Disease” (RESISTA-PD; ID: NCT02784145), we aimed at altering by an...
Abstract Seminal plasma contains a variety of extracellular vesicles (EVs) that deliver RNAs including microRNAs (miRNAs) molecules. However, the roles these EVs along with their delivered and interactions male infertility are not clear. Sperm-associated antigen 7 (SPAG 7) is expressed in germ cells plays crucial role several biological functions associated sperm production maturation. In this study, we aimed to identify post-transcriptional regulation SPAG7 seminal (SF-Native)...
Previous work on murine models and humans demonstrated global as well tissue-specific molecular ageing trajectories of RNAs. Extracellular vesicles (EVs) are membrane mediating the horizontal transfer genetic information between different tissues. We sequenced small regulatory RNAs (sncRNAs) in two mouse plasma fractions at five time points across lifespan from 2–18 months: (1) sncRNAs that free-circulating (fc-RNA) (2) bound outside or inside EVs (EV-RNA). Different sncRNA classes exhibit...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoid tumor which occasionally Epstein-Barr virus (EBV) positive and further subtyped as activated DLBCL (ABC-DLBCL) germinal center (GCB-DLBCL), has implications for prognosis treatment. We performed Ago2 RNA immunoprecipitation followed by high-throughput sequencing (Ago2-RIP-seq) to capture functionally active microRNAs (miRNAs) in EBV-negative ABC-DLBCL GCB-DLBCL cell lines their EBV-infected counterparts. In parallel, total miRNA...
Abstract The composition of the gut microbiome is linked to multiple diseases, including Parkinson’s disease (PD). Bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions humans. In interventional, monocentric, open-label clinical trial RESISTA-PD ( NCT02784145 ) we aimed at altering by an 8-week prebiotic intervention with resistant starch (RS). We enrolled 87 subjects three study-arms: 32 PD patients...
Previous work on murine models and human demonstrated global as well tissue-specific molecular aging trajectories in solid tissues body fluids 1–8 . Extracellular vesicles like exosomes play a crucial role communication information exchange between such systemic factors 9,10 We sequenced freely circulating vesicle-bound small regulatory RNAs mice at five time points across the average life span from 2 to 18 months. Intriguingly, each RNA class exhibits unique patterns, which showed...