A5024856946- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Protein purification and stability
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Polymer Surface Interaction Studies
- Advanced Polymer Synthesis and Characterization
- Terahertz technology and applications
- Advanced Drug Delivery Systems
- Gyrotron and Vacuum Electronics Research
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Supramolecular Self-Assembly in Materials
- Dental materials and restorations
- Photonic and Optical Devices
- Synthetic Organic Chemistry Methods
- Drug Solubulity and Delivery Systems
- Bacteriophages and microbial interactions
- Dendrimers and Hyperbranched Polymers
- Lipid Membrane Structure and Behavior
- Nanoparticles: synthesis and applications
- Superconducting and THz Device Technology
- Glycosylation and Glycoproteins Research
University of Pittsburgh
2023-2025
Institut National de la Recherche Scientifique
2015-2024
ETH Zurich
2010-2022
Fondation pour la Recherche Médicale
2021
Varian Medical Systems (Switzerland)
2016-2020
National Academies of Sciences, Engineering, and Medicine
1993-2018
École Polytechnique Fédérale de Lausanne
2008-2013
Université de Montréal
2004-2009
Shanxi University
2009
BioMat Sciences (United States)
2005
Post-polymerization modification is based on the direct polymerization or copolymerization of monomers bearing chemoselective handles that are inert towards conditions but can be quantitatively converted in a subsequent step into broad range other functional groups. The success this method excellent conversions achievable under mild conditions, functional-group tolerance, and orthogonality post-polymerization reactions. This Review surveys different classes reactive polymer precursors...
Abstract Benefiting from the advantageous features of high safety, abundant reserves, low cost, and energy density, aqueous Zn‐based rechargeable batteries (AZBs) have received extensive attention as promising candidates for storage. To achieve high‐performance AZBs with reversibility great efforts been devoted to overcoming their drawbacks by focusing on modification electrode materials electrolytes. Based different cathode electrolytes, development redox mechanisms are discussed in this...
Proteins have been modified with polymers in diverse manners over the past 30 years. However, while proteins used to prepare many functional constructs, they are sensitive biomolecules and their bioactivity can be either positively or negatively influenced by different aspects of polymer modification. The primary focus this review article is highlight opportunities offered new trends protein modification, specifically how influence overall biological activity conjugate, including its...
In recent years, experimental demonstration of ferroelectric tunnel junctions (FTJ) based on perovskite barriers has been reported. However, integrating these materials into conventional silicon memory technology remains challenging due to their lack compatibility with the complementary metal oxide semiconductor process (CMOS). This communication reports fabrication an FTJ a CMOS-compatible barrier Hf0.5Zr0.5O2 (6 unit cells thick) equally TiN electrode. Analysis by grazing angle incidence...
The present work reports the fabrication of a ferroelectric tunnel junction based on CMOS compatible 2.8 nm-thick Hf0.5Zr0.5O2 barrier. It presents comprehensive study electronic properties Pt/Hf0.5Zr0.5O2/Pt system by X-ray photoelectron and UV-Visible spectroscopies. Furthermore, two different scanning probe techniques (Piezoresponse Force Microscopy conductive-AFM) were used to demonstrate behavior ultrathin layer as well typical current-voltage characteristic device. Finally, direct...
Abstract The deposition of insoluble proteinaceous aggregates in the form amyloid fibrils within extracellular space tissues is associated with numerous diseases. development molecular approaches to arrest formation and prevent cellular degeneration remains very challenging due complexity process protein aggregation, which encompasses an infinite array conformations quaternary structures. Polyanionic biopolymers, such as glycosaminoglycans RNAs, have been shown modulate self‐assembly...
Oxygen inhibits free radical polymerization and yields polymers with uncured surfaces. This is a concern when thin layers of resin are being polymerized, or in circumstances where conventional means eliminating inhibition inappropriate. In this study, we tested the hypothesis that viscosity, filler content, temperature modify oxygen diffusion reactivity species, affect degree conversion near surface. Confocal Raman micro-spectroscopy was used to measure monomer from surface bulk cured...
Stimuli-responsive drug delivery systems can release therapeutic agents when actuated by an appropriate stimulus, whether endogenous or exogenous. Interestingly, exogenous stimuli are completely dissociated from the patient's physiology and be precisely controlled externally in magnitude, space, time. They therefore constitute more reproducible means of controlling therapeutics appropriately responsive systems. One stimulus which has long attracted attention is application electric...
Disulfides enhance the transfection efficacy and reduce toxicity of cationic gene delivery polymers. A quantitative analysis is provided bioreduction a dynamic bioreducible dendritic polycationic probe in four cell lines. Such knowledge indispensible for understanding optimizing drug systems.
Abstract The interplay between the chemical microenvironment surrounding disulfides and redox environment of media on thiol–disulfide exchange kinetics was examined by using a peptide platform. Exchange up to 34 cysteine‐containing peptides were measured in several buffers. electrostatic attraction/repulsion charged reducing agents such as glutathione found have very pronounced effect (differences ca. three orders magnitude). could be directly correlated charge over entire range examined....
Many potent drugs are difficult to administer intravenously due poor aqueous solubility. One validated approach for addressing this issue is process them into colloidal dispersions known as "nanocrystals" (NCs). However, NCs possess high-energy surfaces that must be stabilized with surfactants prevent aggregation. In addition, the stabilizer provides a means of anchoring targeting moieties achieving deposition or uptake at specified locations. Nevertheless, critical challenge surfactant (and...
Graphene, one of the most promising two-dimensional (2D) nanomaterials, has gained substantial attention in several areas materials science. Due to its unique mechanical, electrical, optical, and thermal properties, graphene-based have triggered both numerous fundamental studies technological applications. Out synthetic methods, chemical vapour deposition (CVD) emerged as methods for production large high quality single-crystal graphene. This review introduces growth mechanisms CVD graphene,...
We report the generation of free space terahertz (THz) pulses with energy up to 8.3 ± 0.2 µJ from an encapsulated interdigitated ZnSe Large Aperture Photo-Conductive Antenna (LAPCA). An aperture 12.2 cm2 is illuminated using a 400 nm pump laser multi-mJ energies at 10 Hz repetition rate. The calculated THz peak electric field 331 4 kV/cm spectrum characterized by median frequency 0.28 THz. Given its relatively low frequency, this will accelerate charged particles efficiently having very...