A5061195677- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Urological Disorders and Treatments
- Bone Tissue Engineering Materials
- Hippo pathway signaling and YAP/TAZ
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Barrier Structure and Function Studies
University of Pittsburgh
2015-2021
McGowan Institute for Regenerative Medicine
2015-2020
University of Pittsburgh Medical Center
2020
Presbyterian Hospital
2020
UPMC Presbyterian
2020
Biologic scaffolds composed of extracellular matrix (ECM) have been used to facilitate repair or remodeling numerous tissues, including the esophagus. The theoretically ideal scaffold for tissue is ECM derived from particular be treated, that is, site-specific homologous ECM. preference potential advantage use remains unknown in esophageal location. objective present study was characterize vitro cellular response and vivo host a (eECM) versus nonhomologous ECMs small intestinal submucosa...
Chronic inflammatory gastric reflux alters the esophageal microenvironment and induces metaplastic transformation of epithelium, a precancerous condition termed Barrett's esophagus (BE). The microenvironmental niche, which includes extracellular matrix (ECM), substantially influences cell phenotype. ECM harvested from normal porcine mucosa (eECM) was formulated as mucoadhesive hydrogel, shown to largely retain basement membrane matrix-cell adhesion proteins. Dogs with BE were treated orally...
Objective To establish a miRNA signature for metastasis in an animal model of esophageal adenocarcinoma (EAC). Background The incidence (EAC) has dramatically increased and cancer is now the sixth leading cause deaths worldwide. Mortality rates remain high among patients with advanced stage disease esophagectomy associated complication rates. Hence, early identification potentially metastatic would better guide treatment strategies. Methods modified Levrat's surgery was performed to induce...
Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after resection and promoted regrowth of normal mucosa without recurrence cancer. The present study investigates the mechanisms by which these materials successful prevent cancerous phenotype. ECM downregulated neoplastic cell function (proliferation, metabolism), but epithelial cells unaffected in vitro, suggests a molecular basis (downregulation PI3K-Akt, cycle) for promising clinical results. therapeutic...
Introduction: Esophageal adenocarcinoma (EAC) has a 20% 5-year survival rate despite the current standard of care. EAC progresses in response to microenvironmental change, i.e., chronic gastric reflux and associated inflammation. A primary component microenvironment is extracellular matrix (ECM), which directs cell phenotype by dynamic reciprocity. The present study evaluated effect non-malignant urinary bladder ECM (UBM ECM) esophageal (eECM) hydrogels, delivered orally vivo upon carcinoma...