A5107141390- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Abdominal Surgery and Complications
- Electrospun Nanofibers in Biomedical Applications
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Preterm Birth and Chorioamnionitis
- Corneal Surgery and Treatments
- Graphene and Nanomaterials Applications
- Proteoglycans and glycosaminoglycans research
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Tissue Engineering and Regenerative Medicine
Georgia Institute of Technology
2012-2019
The Wallace H. Coulter Department of Biomedical Engineering
2013-2019
Bioengineering Center
2016
Parker Hannifin (United States)
2016
AID Atlanta
2016
Surgical mesh devices composed of synthetic materials are commonly used for ventral hernia repair. These provide robust mechanical strength and quickly incorporated into host tissue; factors that contribute to reduced recurrence rates. However, such cause a foreign body response with the associated complications fibrosis patient discomfort. In contrast, surgical naturally occurring extracellular matrix (ECM) constructive tissue remodeling, but lack materials. A method applying porcine dermal...
Abstract Introduction Adipose stem cells (ASCs) secrete many trophic factors that can stimulate tissue repair, including angiogenic factors, but little is known about how ASCs and their secreted influence cartilage regeneration. Therefore, the aim of this study was to determine effects ASC-secreted have in repairing chondral defects. Methods isolated from male Sprague Dawley rats were cultured monolayer or alginate microbeads supplemented with growth (GM) chondrogenic medium (CM). Subsequent...
Recent endeavors to use stem cells as trophic factor production sources have the potential translate into viable therapies for damaged or diseased musculoskeletal tissues. Adipose (ASCs) can be differentiated chondrocytes using chondrogenic medium (CM), but it is unknown if this approach optimize ASC growth secretion cartilage regeneration by increasing production, while decreasing angiogenic and hypertrophic production. The objective of study was determine effects CM its components on from...
Osteoarthritis (OA) is a widespread disease that continues to lack approved and efficacious treatments modify progression. Micronized dehydrated human amnion/chorion membrane (μ-dHACM) has been shown be effective in reducing OA progression, but many of the engineering design parameters have not explored. The objectives this study were characterize particle size distributions two μ-dHACM formulations investigate influence these on vivo therapeutic efficacy μ-dHACM. Male Lewis rats underwent...
While mesenchymal stem cell (MSC)-based strategies for critically-sized bone defect repair hold promise, poor survival<italic>in vivo</italic>remains a significant barrier to the translation of these therapeutics.
Microencapsulating stem cells in injectable microbeads can enhance delivery and localization, but their ability to act as growth factor production sources is still unknown. To address this concern, mRNA levels from alginate with encapsulated human adipose (ASC microbeads) cultured both chondrogenic media (GM CM) were measured over a two week period. Human ASCs either commercially purchased (Lonza) or isolated six donors compared on tissue culture polystyrene (TCPS). The effects of...