A5052092464- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Infectious Diseases and Tuberculosis
- Global Health and Surgery
- Botulinum Toxin and Related Neurological Disorders
- Family and Disability Support Research
- Cardiac Arrest and Resuscitation
- Assisted Reproductive Technology and Twin Pregnancy
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- Global Health Workforce Issues
- Child Abuse and Related Trauma
- Bacterial Infections and Vaccines
- Pituitary Gland Disorders and Treatments
- Sepsis Diagnosis and Treatment
- History of Medical Practice
- Infant Development and Preterm Care
- Anatomy and Medical Technology
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal pain and rehabilitation
- Folate and B Vitamins Research
- Organ Donation and Transplantation
University of Cape Town
2015-2024
Neuroscience Institute
2020-2024
Groote Schuur Hospital
2013-2024
Red Cross War Memorial Children's Hospital
2009-2023
Hospital Nacional de Niños
2021
American College of Surgeons
2019
Canadian Anesthesiologists' Society
2019
Royal College of Surgeons of England
2019
Shriners Hospitals for Children - Northern California
2019
University of California, San Diego
2019
Worldwide disparities in the provision of surgical care result otherwise preventable disability and death. There is a growing need to quantify global burden neurosurgical disease specifically, workforce necessary meet this demand.
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC component of wide array genetic syndromes as well secondary consequence brain injury (intraventricular hemorrhage (IVH), infection, etc.) can present across the age spectrum, highlighting phenotypic heterogeneity disease. Surgical treatments include ventricular shunting and endoscopic third ventriculostomy with or without choroid...
Recommendations by the Lancet Commission on Global Surgery regarding surgical care in low- and middle-income countries (LMICs) require development to address needs of children. The Initiative for Children's (GICS) was founded 2016 identify solutions problems children's surgery utilizing expertise practitioners from around world. This report details this unique process underlying principles.Three global meetings convened providers services Through working group meetings, participants reviewed...
Object Selective dorsal rhizotomy (SDR) has been widely performed for the reduction of spasticity in patients with cerebral palsy during past 2 decades. The objective this study was to determine whether surgery yielded long-term functional benefits these patients. Methods authors present results from a prospective 20-year follow-up locomotor function 13 who underwent an SDR 1985. For comparison, we also gait data 48 age-matched healthy controls (12 at each 4 time points). Patients were...
Cerebral pressure autoregulation is an important neuroprotective mechanism that stabilizes cerebral blood flow when (BP) changes. In this study the authors examined association between and clinical factors, BP, intracranial (ICP), brain tissue oxygen tension (PbtO(2)), outcome after pediatric severe traumatic injury (TBI). particular we how status of influenced effect BP changes on ICP PbtO(2).In prospective observational study, 52 tests were performed in 24 patients with TBI. The had a mean...
Effective treatment of children with medulloblastoma requires a functioning multi-disciplinary team adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities personnel. In addition the treating centre should have capacity to effectively screen manage any tumour treatment-associated complications. These requirements made it difficult for many low middle-income countries (LMIC) centres offer curative treatment. This article provides management...
Tuberculous meningitis (TBM) is a lethal and commonly occurring form of extra-pulmonary tuberculosis in children, often complicated by hydrocephalus which worsens outcome. Despite high mortality morbidity, little data on the impact neurodevelopment exists. We examined clinical characteristics, neurodevelopmental outcomes TBM hydrocephalus.Demographic (laboratory radiological findings) were prospectively collected children treated for probable definite with hydrocephalus. At 6 months, outcome...
Neurosurgical task shifting and sharing (TS/S), delegating clinical care to non-neurosurgeons, is ongoing in many hospital systems which neurosurgeons are scarce. Although TS/S can increase access treatment, it remains highly controversial. This survey investigated perceptions of neurosurgical elucidate whether a permissible temporary solution the global workforce deficit. The was distributed convenience sample individuals providing care. A digital link through electronic mailing lists...
Introduction: Africa has many untreated neurosurgical cases due to limited access safe, affordable, and timely care. In this study, we surveyed young African neurosurgeons trainees identify challenges training practice. Methods: residents were online by the Young Neurosurgeons Forum from April 25th November 30th, 2018. The survey link was distributed via social media platforms through professional society mailing lists. Univariate bivariate data analyses run a P -value < 0.05...
Paradoxical enlargement and development of new intracranial tuberculomas tuberculous brain abscesses on adequate antituberculosis treatment are well recognized supposedly cytokine mediated. These lesions often unresponsive to conventional treatment, corticosteroids, surgery. We therefore assessed the effect adjunctive thalidomide, a tumor necrosis factor alpha-modulating drug, in intractable tuberculosis that did not respond standard medical surgical therapy. Four consecutive children (three...
The indications for blood transfusion in traumatic brain injury are controversial. In particular, little is known about the effect of childhood injury. This study aimed to examine influence on tissue oxygen tension children with severe injury.A retrospective analysis a prospective observational database who received monitoring and transfusion.University-affiliated pediatric hospital.Children transfusion.None.Brain was measured normal-appearing white matter commercially available...
Intracranial pressure (ICP) monitoring is a cornerstone of care for severe traumatic brain injury (TBI). Management ICP can help ensure adequate cerebral blood flow and oxygenation. However, studies indicate that hypoxia may occur despite normal the relationship between oxygenation poorly defined. This particularly important children in whom less known about intracranial dynamics.To examine partial tissue oxygen (PbtO2) with TBI (Glasgow Coma Scale score ≤ 8) admitted to Red Cross War...