A5083504650- Liver physiology and pathology
- Global Health and Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Global Health Workforce Issues
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Diversity and Career in Medicine
- Bariatric Surgery and Outcomes
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Anomalies and Fetal Surgery
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- Genetics and Neurodevelopmental Disorders
- Teratomas and Epidermoid Cysts
- Growth Hormone and Insulin-like Growth Factors
- Obesity and Health Practices
- Tumors and Oncological Cases
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
University of Illinois Chicago
2007-2023
Illinois College
2013-2023
American College of Surgeons
2019
Canadian Anesthesiologists' Society
2019
Royal College of Surgeons of England
2019
Shriners Hospitals for Children - Northern California
2019
King's College London
2019
Rady Children's Hospital-San Diego
2019
University of California, San Diego
2019
Children's Hospital of Illinois
2013-2017
Two-thirds partial hepatectomy (PH) induces differentiated cells in the liver remnant to proliferate and regenerate its original size. The proliferation-specific HNF-3/fork head homolog-11B protein (HFH-11B; also known as Trident Win) is a family member of winged helix/fork transcription factors regenerating expression reactivated prior hepatocyte entry into DNA replication (S phase). To examine whether HFH-11B regulates proliferation during regeneration, we used −3-kb transthyretin (TTR)...
ABSTRACT Background: We received the LAP‐BAND Investigational Device Exemption (IDE) from US Food and Drug Administration in December 2004 to conduct a prospective longitudinal trial examining safety efficacy of laparoscopic adjustable gastric banding (LAGB) morbidly obese adolescents ages 14 17 years. Objectives: To report short‐term results LAGB first 10 with complete 9 months follow‐up. Patients Methods: Baseline characteristics outcome data were analyzed patients enrolled between March...
Hepatic stellate cell (HSC) activation via the autophagy pathway is a critical factor in liver fibrogenesis. This study tests hypothesis that chloroquine (CQ) treatment can prevent and HSC vitro vivo bile-duct-ligated (BDL) mice. Sham-operated BDL mice were treated with either PBS or CQ two 60 mg/kg doses day (D) before after surgery. On 2 (2D), HSCs isolated, their biological activities evaluated by measuring intracellular lipid content, α-sma/collagen, expression of lc3, sqstm1/p62...
ABSTRACT Herpes simplex virus (HSV) inhibits major histocompatibility complex (MHC) class I expression in infected cells and does so much more efficiently human than murine cells. Given this difference, if MHC I-restricted T do not play an important role protection of mice from HSV, for these humans would be unlikely. However, the contribution to control HSV infection remains unclear. Further, mechanisms by which may act infection, particularly nervous system, are well understood, though a...
Biliary epithelial cells (BEC) are morphologically and functionally heterogeneous. To investigate the molecular mechanism for their diversities, we test hypothesis that large small BEC have disparity in target gene response to transcriptional regulator, biliary cell-enriched hepatocyte nuclear factor HNF6. The expression of major HNF ( HNF6, OC2, HNF1b, HNF1a, HNF4a, C/EBPb, Foxa2) representative transport genes dependent were compared between SV40-transformed derived from (SV40LG) (SV40SM)...
Summary Pediatric surgeons, anesthesia providers, and nurses from North America other high‐income countries are increasingly engaged in resource‐limited areas, with short‐term missions as the most common form of involvement. However, consensus recommendations currently do not exist for pediatric general surgery associated perioperative care. The American Academy Pediatrics (AAP) Delivery Surgical Care Subcommittee Association (APSA) Global Surgery Committee, Nurses Association, Inc. ( APSNA...
Hepatic stellate cells (HSCs) activation, a critical event in liver fibrosis, has been recently shown to be related autophagy. Determine whether chloroquine (CQ) could affect (i) the activation of HSC vivo and (ii) hepatic damage mice acute injury model.The was induced BALB/c by carbon tetrachloride (CCl4 group); 24 h before after CCl4 administration animals were treated CQ + group). As control, olive oil considered. After 48 from /olive administration, blood samples, tissues, HSCs harvested...
Growth hormone (GH) function is mediated through multiple endocrine pathways. In the liver, GH also transcriptionally activates hepatocyte nuclear factor-6 (HNF-6; OC-1), a liver-enriched transcription factor that regulates expression of genes essential to hepatic function. We hypothesize modulates in normal and injured liver HNF-6 target genes. CD1 mice received PBS or for 1-, 7-, 28-day course Sham operation bile duct ligation (BDL). Proliferation-, metabolic-, profibrotic-specific...
Abstract Liver fibrosis (LF) mortality rate is approximately 2 million per year. Irrespective of the etiology LF, a key element in its development transition hepatic stellate cells (HSCs) from quiescent phenotype to myofibroblast-like cell with production fibrotic proteins. It necessary define optimal isolation and culturing conditions for good HSCs yield proper preservation studying activation vitro. In present study, HSC culture were examined maintain HSC’s undifferentiated phenotype....