A5072654059- Bariatric Surgery and Outcomes
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Obesity and Health Practices
- Cardiovascular Disease and Adiposity
- Intestinal Malrotation and Obstruction Disorders
- Appendicitis Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Eating Disorders and Behaviors
- Immune Response and Inflammation
- Clinical Nutrition and Gastroenterology
- Global Health and Surgery
- Venous Thromboembolism Diagnosis and Management
- Infant Nutrition and Health
- Pharmacology and Obesity Treatment
- Nitric Oxide and Endothelin Effects
- Esophageal and GI Pathology
- Adipose Tissue and Metabolism
- Body Contouring and Surgery
- Diversity and Career in Medicine
- Gastroesophageal reflux and treatments
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
Hospital for Sick Children
2024-2025
Children's National
2015-2024
St. Francis Hospital
2024
Hartford Financial Services (United States)
2024
George Washington University
2013-2023
National Hospital
2023
St. Francis Hospital
2022
George Washington University Hospital
2021
UConn Health
2016-2020
University of Connecticut
2017-2020
Background: Previous evidence-based guidelines on the management of intra-abdominal infection (IAI) were published by Surgical Infection Society (SIS) in 1992, 2002, and 2010. At time most recent guideline was released, plan to update every five years ensure timeliness appropriateness recommendations. Methods: Based previous guidelines, task force outlined a number topics related treatment patients with IAI then developed key questions these various topics. All approached using general...
Exosomes from obese adipose contain dysregulated microRNAs linked to insulin signaling, as compared with lean controls, providing a direct connection between adiposity and resistance. This study tested the hypotheses that gastric bypass surgery its subsequent weight loss would normalize adipocyte-derived exosomal associated signaling metabolome related glucose homeostasis.African American female subjects obesity (N = 6; age: 38.5 ± 6.8 years; BMI: 51.2 8.8 kg/m2 ) were before 1 year after...
Bariatric surgery is highly effective in achieving weight loss children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, gut microbiome changes unknown. Here, we show that exhibit significant metabolome shifts several months after laparoscopic vertical sleeve gastrectomy (VSG), increased alpha diversity notably enrichment of oral-associated taxa. To assess causality microbiome/metabolome phenotype, pre-VSG post-VSG stool was transplanted...
To determine the current rate of inpatient bariatric surgical procedures among adolescents and to analyze national trends use from 2000 2009.Retrospective cross-sectional study.Discharge data obtained Healthcare Cost Utilization Project Kids' Inpatient Database, through 2009.Adolescents (defined herein as individuals aged 10-19 years) undergoing procedures.Inpatient surgery.The primary outcome measure was population-based procedure rate. The secondary measures were in rates type,...
Quality of life (QoL) is an important outcome to evaluate in adolescents with severe obesity, yet intrapersonal predictors QoL are understudied. The current study assessed whether difficulty impulse control when experiencing a negative mood (negative urgency) associated poorer QoL, mediated by more emotional eating and food addiction. Participants consisted 69 primarily female (71%), minority (76%) aged 13-21 (M age = 16.5, SD 1.5) obesity presenting for prebariatric surgery psychological...
Background Although the presence of a contrast blush (CB) on computed tomographic (CT) scan is associated with an increased failure rate nonoperative management in adults blunt splenic injury, little information available for pediatric population, where standard care. Our aim was to determine whether finding CB CT could predict therapy children injury. Methods A retrospective analysis 343 patients admitted injury our Level I trauma center over 7-year period performed. All scans were reviewed...
Background: The Surgical Infection Society published their most recent recommendations for antimicrobial therapy in patients with intra-abdominal infections 2002. These guidelines outlined several important considerations the treatment of such infections, including which require agents, appropriate duration treatment, regimens are appropriate, and risk factors indications intensified regimens. However, applicability these to pediatric population is not entirely clear. Methods: Systematic...
Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage capacity. an adolescent cohort (n = 93, Age, median (IQR) 17 (3) year, Female 71, Male 22) throughout BMI continuum (BMI 45.2 (13.2) kg/m2) for: (1) lipoprotein profiles; (2) in serum; role of visceral adipose tissue regulation gene expression THP-1 macrophages vitro. Efflux was...
Initial non-operative therapy for children with perforated appendicitis has become increasingly popular the advent of powerful broad-spectrum antibiotics. However, there is no consensus regarding which patients may be managed effectively this strategy. We reviewed all who were treated initially to determine those characteristics that predict a successful outcome.We medical records admitted our hospital between January 1, 2000 and May 2003 diagnosis appendicitis. Only single antibiotic...
Obesity is a complex, chronic disease affecting more than one-fifth of adolescent children aged 12-19 years in the United States. Recent guidelines have recommended optimization diagnosis and treatment approaches to help improve immediate long-term health people with obesity. Here, we describe insights recommendations 9 nationally recognized experts pediatric obesity, summarized from virtual advisory board discussion. Advisors described their background, experiences, patient populations,...
Background: Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spinal condition. During growth, moderate treated with a brace to minimize risk of progression surgical range. However, minority patients meet indications, greater number presenting late, already appropriate for surgery. This study determines treatment cost differential between candidates and late-presenting within public health care setting. Methods: retrospective review 373 consecutive AIS seen initial...