A5041969865- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Sexual Differentiation and Disorders
- Air Quality and Health Impacts
- Atherosclerosis and Cardiovascular Diseases
- Homicide, Infanticide, and Child Abuse
- Homelessness and Social Issues
- Stress Responses and Cortisol
- Grief, Bereavement, and Mental Health
- Circular RNAs in diseases
Children's National
2019-2023
National Hospital
2022-2023
City University of New York
2023
Hunter College
2023
New York University
2023
National Institute of Mental Health
2022
Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage capacity. an adolescent cohort (n = 93, Age, median (IQR) 17 (3) year, Female 71, Male 22) throughout BMI continuum (BMI 45.2 (13.2) kg/m2) for: (1) lipoprotein profiles; (2) in serum; role of visceral adipose tissue regulation gene expression THP-1 macrophages vitro. Efflux was...
Alzheimer disease (AD) is characterized by amyloid-β (Aβ) plaques, neurofibrillary tangles, synaptic dysfunction, and progressive dementia. Midlife obesity increases the risk of developing AD. Adipocyte-derived small extracellular vesicles (ad-sEVs) have been implicated as a mechanism in several obesity-related diseases. We hypothesized that ad-sEVs from patients with AD would contain miRNAs predicted to downregulate pathways involved plasticity memory formation. isolated serum cerebrospinal...
Aging is a risk factor for many non-communicable diseases such as cardiovascular and neurodegenerative diseases. Extracellular vesicles particles (EVP) carry microRNAs that may play role in age-related induce oxidative stress. We hypothesized aging could impact EVP miRNA impair redox homeostasis, contributing to chronic Our aims were investigate the microRNA profiles of circulating total EVPs from aged young adult animals evaluate pro- antioxidant machinery EVPs. Plasma 3- 21-month-old male...
Aging is associated with adipose tissue dysfunction and recognized as a risk factor for shortened life span. Considering that in vitro findings have shown the involvement of microRNA extracellular vesicles particles (EVPs) on senescence, we hypothesized circulating EVPs derived from adipocytes can be involved aging process via their cargo. We aimed to determine profiles (FABP4+) aged young adult animals perform silico prediction downstream signaling effects. Plasma was obtained Wistar rats...
Abstract Background Maternal body size, nutrition, and hyperglycemia contribute to neonatal size composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal cord blood explore their adipogenic potential. Methods studied 127 mother-neonate pairs (51 lean 76 adipose neonates, 68 NGT 59 GDM pregnancies). Adiposity refers the highest tertile (T3) sum...
Abstract Background Maternal body size, nutrition, and hyperglycemia contribute to neonatal size composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal cord blood explore their adipogenic potential. Methods studied 127 mother-neonate pairs (51 lean 76 adipose neonates, 68 NGT 59 GDM pregnancies). Adiposity refers highest tertile (T3) sum...
Background: Maternal body size, nutrition, and hyperglycemia contribute to neonatal size composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal cord blood explore their adipogenic potential.Methods: studied 127 mother-neonate pairs (51 lean 76 adipose neonates, 68 NGT 59 GDM pregnancies). Adiposity refers the highest tertile (T3) sum skinfolds...